Biological Responses to Air Ions: Is There a Role for Serotonin?

Air Ions ◽  
2018 ◽  
pp. 161-170
Keyword(s):  
Air Ions ◽  
Biological Responses

Is the link between emotional suppression and biological responses to stress mediated by rumination?

2010 ◽  
Author(s):  
Charlotte Leonie Stewart ◽  
Jolanta Opacka-Juffry ◽  
Changiz Mohiyeddini
Keyword(s):  
Emotional Suppression ◽  
Biological Responses

Progress of negative air ions in health tourism environments applications

2018 ◽  
Vol 33 (1) ◽  
pp. 27-46 ◽  
Author(s):  
FT Lazzerini ◽  
MT Orlando ◽  
W De Pra
Keyword(s):  
Air Ions ◽  
Health Tourism ◽  
Negative Air Ions

Nucleotidyl transferase proteins and the biological responses of Zea mays to abiotic stress

2018 ◽  
Vol 35 (5) ◽  
pp. 536
Author(s):  
Jiayun LU ◽  
Jianbo SONG ◽  
Xiaoyan WANG ◽  
Xiaowei MO ◽  
Suikang WANG ◽  
...  
Keyword(s):  
Zea Mays ◽  
Abiotic Stress ◽  
Nucleotidyl Transferase ◽  
Biological Responses

Uncertainties Associated with Assessing the Risk of an Endocrine Active Substance in the Canadian Environment

2001 ◽  
Vol 36 (2) ◽  
pp. 319-330 ◽  
Author(s):  
Mark Servos ◽  
Don Bennie ◽  
Kent Burnison ◽  
Philippa Cureton ◽  
Nicol Davidson ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Endocrine Disruption ◽  
Endocrine System ◽  
Problem Formulation ◽  
Normal Function ◽  
Weight Of Evidence ◽  
Biological Responses ◽  
Low Concentrations ◽  
Multigenerational Effects

Abstract A number of biological responses and multigenerational effects, mediated through the disruption of endocrine systems, have been observed in biota exposed to relatively low concentrations of environmental contaminants. These types of responses need to be considered within a weight of evidence approach in our risk assessment and risk management frameworks. However, including endocrine responses in an environmental risk assessment introduces a number of uncertainties that must be considered. A risk assessment of nonylphenol and nonylphenol polyethoxylates (NP/NPE) is used as a case study to demonstrate the sources and magnitude of some of the uncertainties associated with using endocrine disruption as an assessment endpoint. Even with this relatively well studied group of substances, there are substantial knowledge gaps which contribute to the overall uncertainties, limiting the interpretation within the risk assessment. The uncertainty of extrapolating from in vitro or biochemical responses to higher levels of organization or across species is not well understood. The endocrine system is very complex and chemicals can interact or interfere with the normal function of endocrine systems in a number of ways (e.g., receptors, hormones) which may or may not result in an adverse responses in the whole organism. Using endocrine responses can lead to different conclusions than traditional endpoints due to a variety of factors, such as differences in relative potencies of chemicals for specific endpoints (e.g., receptor binding versus chronic toxicity). The uncertainties can also be considerably larger and the desirability of using endocrine endpoints should be carefully evaluated. Endocrine disruption is a mode of action and not a functional endpoint and this needs to be considered carefully in the problem formulation stage and the interpretation of the weight of evidence.

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

2019 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Cong Tang ◽  
Guodong Zhu
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Cell Receptor ◽  
Transmembrane Receptors ◽  
Biological Responses ◽  
Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

Preliminary Assessment of Human Biological Responses to Low-level Ozone

2020 ◽  
Author(s):  
Tahmid Latif ◽  
Laura Gonzalez ◽  
James Dieffenderfer ◽  
Yuwei Liao ◽  
Michelle Hernandez ◽  
...  
Keyword(s):  
Preliminary Assessment ◽  
Low Level ◽  
Biological Responses

scholarly journals Genomic markers for the biological responses of Triclosan stressed hatchlings of Labeo rohita

2021 ◽  
Author(s):  
Sunil Sharma ◽  
Owias Iqbal Dar ◽  
Kirpal Singh ◽  
Sharad Thakur ◽  
Anup Kumar Kesavan ◽  
...  
Keyword(s):  
Labeo Rohita ◽  
Biological Responses ◽  
Genomic Markers
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