Prolactin Interaction with its Receptors and the Relationship to the Subsequent Regulation of Metabolic Processes

2018 ◽  
pp. 5-26
Author(s):  
Mark E. Costlow
Keyword(s):  
Metabolic Processes ◽  
The Relationship

PSI-B-26 Association of leptin gene polymorphisms (C73T and C528T) on the development of internal organs in Aberdeen-angus cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 224-225
Author(s):  
Alexandra Lapshina ◽  
Nikolay Gerasimov ◽  
Kinispay Dzhulamanov ◽  
Vladimir Kolpakov ◽  
Erzhan Dzhulamanov
Keyword(s):  
Financial Support ◽  
Gene Polymorphisms ◽  
Energy Exchange ◽  
Spleen Weight ◽  
Metabolic Processes ◽  
Internal Organs ◽  
Plant Foods ◽  
Angus Cattle ◽  
Relationship Of ◽  
The Relationship

Abstract Numerous studies have established the relationship of SNPs in the leptin gene with fat and energy exchange, nutritional behavior in cattle. In turn, the intensity of metabolic processes in body is determined by the development of internal organs. The purpose of research was to study the relationship between the complex of polymorphisms C73T and C528T in leptin gene for the formation of internal organs in Aberdeen-Angus cows and heifers. Cows (n = 30) and heifers (n = 49) were genotyped and identified respectively 7 and 8 various combinations of genotypes of C73T (GenBank AF120500) and C528T (GenBank AB070368). There were no homozygous CC/CC and TT/TT combinations in cows, and no TT/TT combination in heifers. Cows were slaughtered at the age of 3 years, and heifers - at 20 months. Cows with haplotype CT/CC had the highest liver, heart, lung, kidney and spleen weight with superiority relative to peers of 6.5–16.0% (P > 0.05). The minimum development of stomachs was established at cows with a combination of genotypes of CC/TT which conceded to analogs for 7.6–13.8% (P > 0.05). Haplotypes CT/CT and TT/CT in heifers were associated with greater internal organ massiveness. Carriers of complex CT/CT genotype outperformed peers in terms of liver, heart, lung, kidney and spleen weight by 1.75–6.59% (P < 0.05, P > 0.05), and individuals with a combination of TT/CT by 3.50–8.84% (P < 0.05, P > 0.05). Less developed stomachs were established in bodies with haplotype TT/CC, which were inferior to other genotypes by 1.20–7.49% (P < 0.05, P > 0.05). This indirectly indicates a relatively weak ability to use coarse plant foods. Thus, the complex genotype inleptin gene is associated with the variability in the development of internal organs, which determines the intensity of metabolic processes. This research was performed with financial support from the project of RAS0526-2021-0001.

Neonatal diabetes mellitus: the effectiveness of therapy with sulfonylurea preparations depending on the type of mutation in the KCNJ11 gene

2014 ◽  
Vol 60 (1) ◽  
pp. 57-63
Author(s):  
A O Emelyanov ◽  
T L Kuraeva ◽  
S A Prokofiev ◽  
E D Medvedeva ◽  
V A Peterkova
Keyword(s):  
Diabetes Mellitus ◽  
Potassium Channels ◽  
Beta Cells ◽  
Clinical Significance ◽  
Newborn Infants ◽  
Neonatal Diabetes ◽  
Neonatal Diabetes Mellitus ◽  
Metabolic Processes ◽  
Kcnj11 Gene ◽  
The Relationship

Neonatal diabetes mellitus (NDM) develops within the first 6 months of life. It occurs with a frequency of 1 cases per 300,000 - 500,000 newborn infants. Pathogenesis of NDM involves over 10 different genes. Of greatest clinical significance are mutations in KCNJII and ABCC8 genes responsible for the activity of ATP-dependent potassium channels and regulating their activation. It was shown that the intake of oral sulfonylurea (SU) preparations results in the closure of these channels and thereby stimulates the release of insulin from beta-cells. For this reason, SU therapy can be applied as an alternative to insulin injections. SU preparations ensure the efficacious control of metabolic processes and substitute insulin in the majority of the cases of transient and permanent NDM associated with mutations in KCNJII and ABCC8 genes. The original observations demonstrating the relationship between the type of mutation in the KCNJII gene and the dose of SU preparations are presented.

Determination of the milk yield of sows and correction for loss of weight due to metabolic processes of piglets during suckling

1964 ◽  
Vol 6 (1) ◽  
pp. 119-123 ◽  
Author(s):  
R. L. Van Spaendonck ◽  
F. X. Vanschoubroek
Keyword(s):  
Milk Yield ◽  
The Body ◽  
The Other ◽  
Weight Changes ◽  
Metabolic Processes ◽  
Loss Of Weight ◽  
Before And After ◽  
The One ◽  
The Relationship

SUMMARYIn determining the milk yield of the sow by weighing the litter before and after suckling, loss of weight due to metabolic processes must be considered.An experiment is described to investigate the loss of weight of piglets caused by metabolic processes between two consecutive weighings, and to investigate the relationship between this loss on the one hand and the body weight and the age of the piglets on the other. Weight changes of 15 litters of average 9·8 piglets were studied during 66 weighing periods of 16 minutes, by putting the pigs in a cage, fixed on a differential balance. Each weighing period consisted of 8 periods of 2 minutes, so that in all, loss of weight was studied during 528 2-minute periods.

scholarly journals Genetic diversity in global chicken breeds as a function of genetic distance to the wild populations

2020 ◽  
Author(s):  
Dorcus Kholofelo Malomane ◽  
Steffen Weigend ◽  
Armin Otto Schmitt ◽  
Annett Weigend ◽  
Christian Reimer ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Genetic Differentiation ◽  
Genetic Distance ◽  
Isolation By Distance ◽  
Genetic Distances ◽  
Founder Population ◽  
Wild Populations ◽  
Metabolic Processes ◽  
Evolutionary Forces ◽  
The Relationship

AbstractMigration of populations from their founder population is expected to cause a reduction in genetic diversity and facilitates population differentiation between the populations and their founder population as predicted by the theory of genetic isolation by distance. Consistent with that, a model of expansion from a single founder predicts that patterns of genetic diversity in populations can be well explained by their geographic expansion from the founders, which is correlated to the genetic differentiation. To investigate this in the chicken, we have estimated the relationship between the genetic diversity in 172 domesticated chicken populations and their genetic distances to wild populations. We have found a strong inverse relationship whereby 87.5% of the variation in the overall genetic diversity of domesticated chicken can be explained by the genetic distance to the wild populations. We also investigated if different types of SNPs and genes present similar patterns of genetic diversity as the overall genome. Among different SNP classes, the non-synonymous ones were the most deviating from the overall genome. However, the genetic distances to wild populations still explained more variation in domesticated chicken diversity in all SNP classes ranging from 81.7 to 88.7%. The genetic diversity seemed to change at a faster rate within the chicken in genes that are associated with transmembrane transport, protein transport and protein metabolic processes, and lipid metabolic processes. In general, such genes are flexible to be manipulated according to the population needs. On the other hand, genes which the genetic diversity hardly changes despite the genetic distance to the wild populations are associated with major functions e.g. brain development. Therefore, changes in the genes may be detrimental to the chickens. These results contribute to the knowledge of different evolutionary patterns of different functional genomic regions in the chicken.Author summaryThe chicken was first domesticated about 6000 B.C. in Asia from the jungle fowl. Following domestication, chickens were taken to different parts of the world mainly by humans. Evolutionary forces such as selection and genetic drift have shaped diversification within the chicken species. In addition, new breeds or strains have been developed from crossbreeding programs facilitated by man. These events, together with other breeding practices, have led to genomic alterations causing genetic differentiation between the domesticated chickens and their ancestral/wild population as well as manipulation of the genetic diversity within the domesticated chickens. We investigated the relationship between 172 domesticated chicken populations from different selection, breeding and management backgrounds and their genetic distance to the wild type chickens. We found that the genetic diversity within the populations decreases with the increasing genetic distances to the wild types. Human manipulation of chicken genetic diversity has more effect on the genetic differentiation than simple geographic separations (through migrations) do. We further found that some genes associated with vital functions show evolutionary constraints or persistent selection across the populations and do not comply with this relationship i.e. the genetic diversity within the populations is constant despite the change in the genetic distance to the wild types.

scholarly journals THE CORRELATION BODY MASS INDEX WITH BLOOD PRESSURE ON ELDERLY IN PERERENAN VILLAGE OF MENGWI SUB-DISTRICT OF BADUNG REGENCY

2018 ◽  
Vol 6 (1) ◽  
pp. 14
Author(s):  
Putu Dita Rastiti ◽  
Ni Luh Nopi Andayani ◽  
Ni Wayan Tianing
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
The Elderly ◽  
Analytic Study ◽  
Metabolic Processes ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
The Relationship

Decreased metabolic processes in the elderly followed by decreased physical activity, causing the addition of calories to be converted into fat resulting in overweight. Overweight is one factor that can affect blood pressure and trigger hypertension, so conducted research to determine the relationship between body mass index with blood pressurein the elderly. A cross sectional analytic study with elderly research sample in Pererenan Village of Mengwi Sub-district of Badung Regency was 104 people selected according to inclusion and exclusion criteria. The results showed a significant correlation between body mass index and blood pressure in elderly (p <0.05) and the results showed a thinBMI (15.4%), normal (31.7%), overweight (20.2%), obese I (29.8%), obesity II (2.9%). Similarly, in the frequency of hypotension (1.9%), normal (36.5%), hypertension (34.6%), hypertension I (7.7%), hypertension II (2.9%) . The sample is more overweight, obese than the normal category. For the category of blood pressure more on pre hypertension andhypertension. Thus, excess body mass index can affect the elderly blood pressure. Keywords: body mass index, blood pressure, elderly

scholarly journals Micro-players for macro-roles: aquatic microbes in deep lakes

2016 ◽  
Vol 75 (s1) ◽  
Author(s):  
Cristiana Callieri
Keyword(s):  
Environmental Factors ◽  
Biogeochemical Cycles ◽  
Global Scale ◽  
Deep Lakes ◽  
Metabolic Processes ◽  
Lake Ecosystems ◽  
Aquatic Microbes ◽  
Low Volume ◽  
The Relationship

Despite their relative low volume on a global scale, lakes represent a valuable reserve of accessible freshwaters. Any increase in our understanding of their functioning is a step towards their better exploitation and preservation. Microorganisms drive the metabolic processes that regulate the biogeochemical cycles in lakes; here, I will focus on Archaea and Cyanobacteria as micro-players playing macro-roles in lake ecosystems. In particular, I will present two examples to demonstrate the importance of prokaryotes in lakes: picocyanobacteria and mesophilic archaea. The role of prokaryotes in lakes will be discussed in relation to their taxonomy, dynamics and ecology using these two examples. The challenge, now, is to better understand the relationship between the diversity and the physiology of various ecotypes, how these interact with each other and with environmental factors allowing the proliferation of the most competitive genotypes.

Interstellar gas in the central region of the Galaxy

1967 ◽  
Vol 31 ◽  
pp. 239-251 ◽  
Author(s):  
F. J. Kerr
Keyword(s):  
Central Region ◽  
Galactic Plane ◽  
Neutral Hydrogen ◽  
Continuum Emission ◽  
Galactic Centre ◽  
Interstellar Gas ◽  
Hydrogen Recombination ◽  
The Galaxy ◽  
Centre Region ◽  
The Relationship

A review is given of information on the galactic-centre region obtained from recent observations of the 21-cm line from neutral hydrogen, the 18-cm group of OH lines, a hydrogen recombination line at 6 cm wavelength, and the continuum emission from ionized hydrogen.Both inward and outward motions are important in this region, in addition to rotation. Several types of observation indicate the presence of material in features inclined to the galactic plane. The relationship between the H and OH concentrations is not yet clear, but a rough picture of the central region can be proposed.

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

Choosing a Markov blanket

2020 ◽  
Vol 43 ◽  
Author(s):  
Thomas Parr
Keyword(s):  
Markov Blanket ◽  
Target Article ◽  
The Relationship

Abstract This commentary focuses upon the relationship between two themes in the target article: the ways in which a Markov blanket may be defined and the role of precision and salience in mediating the interactions between what is internal and external to a system. These each rest upon the different perspectives we might take while “choosing” a Markov blanket.

Tinkering with cognitive gadgets: Cultural evolutionary psychology meets active inference

2019 ◽  
Vol 42 ◽  
Author(s):  
Paul Benjamin Badcock ◽  
Axel Constant ◽  
Maxwell James Désormeau Ramstead
Keyword(s):  
Evolutionary Psychology ◽  
Research Program ◽  
Active Inference ◽  
Innovative Research ◽  
Cognitive Faculties ◽  
Cultural Evolutionary ◽  
The Relationship

Abstract Cognitive Gadgets offers a new, convincing perspective on the origins of our distinctive cognitive faculties, coupled with a clear, innovative research program. Although we broadly endorse Heyes’ ideas, we raise some concerns about her characterisation of evolutionary psychology and the relationship between biology and culture, before discussing the potential fruits of examining cognitive gadgets through the lens of active inference.

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