Assessment of Pharmacokinetics and Drug Activity

2005 ◽  
pp. 251-302
Author(s):  
David Taft ◽  
Kevin Sweeney
Keyword(s):  
Drug Activity

Morphologic alterations in bacteroides fragilis following single and combinant beta-lactam exposure

1986 ◽  
Vol 44 ◽  
pp. 304-305
Author(s):  
Michael P. Goheen ◽  
Charles E. Edmiston
Keyword(s):  
Bacteroides Fragilis ◽  
Synergistic Activity ◽  
Beta Lactam ◽  
Clinical Strains ◽  
Drug Activity ◽  
Obligate Anaerobic ◽  
Morphologic Changes

The synergistic activity of antimicrobial combinants against aerobic and facultative microorganisms has been well documented. in comparison, few studies have been performed using obligate anaerobic isolates and antimicrobial combinants. For this study clinical strains of Bacteroides fragilis(BF) were selected to investigate both single/combinant drug activity and cellular morphologic changes when BF is exposed to Imipenem (I), Piperacillin (P), Cefpimizole (C), Imipenem/Piperacillin (I+P), and Imipenem/Cefpimizole (I+C).

Antitumor effect and potentiation of cytotoxic drug activity of a dual topoisomerase inhibitor on breast cancer

2019 ◽  
Author(s):  
I Flörkemeier ◽  
TN Steinhauer ◽  
MT van Mackelenbergh ◽  
B Clement ◽  
DO Bauerschlag
Keyword(s):  
Breast Cancer ◽  
Antitumor Effect ◽  
Cytotoxic Drug ◽  
Drug Activity ◽  
Topoisomerase Inhibitor

scholarly journals Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity.

1979 ◽  
Vol 254 (21) ◽  
pp. 10906-10912
Author(s):  
R.M. Burger ◽  
J. Peisach ◽  
W.E. Blumberg ◽  
S.B. Horwitz
Keyword(s):  
Drug Activity

scholarly journals Investigation of Anticancer Drug Activity 5-Fluorouracil and Some Analog Derivatives by QSAR: Theoretical Study

2020 ◽  
Vol 1660 ◽  
pp. 012032
Author(s):  
Razzaq Abd Al-Zahra Ibrahim Alamery ◽  
Falah Shareef Abed Suhail ◽  
Hussein Kadhem Al-Hakeim
Keyword(s):  
Anticancer Drug ◽  
Theoretical Study ◽  
Drug Activity

scholarly journals Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices

ACS Sensors ◽  
2021 ◽  
Author(s):  
Ashan P. Wettasinghe ◽  
Naveen Singh ◽  
Colton L. Starcher ◽  
Chloe C. DiTusa ◽  
Zakari Ishak-Boushaki ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Activity ◽  
Cell Lysates

Research on drug-receptor interactions and prediction of drug activity via oriented immobilized receptor capillary electrophoresis

2015 ◽  
Vol 36 (19) ◽  
pp. 2433-2441 ◽  
Author(s):  
Chunye Liu ◽  
Xuejiao Zhang ◽  
Hui Jing ◽  
Yanqing Miao ◽  
Lingzhi Zhao ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Drug Activity ◽  
Receptor Interactions ◽  
Immobilized Receptor ◽  
Drug Receptor

scholarly journals Two Distinct Major Facilitator Superfamily Drug Efflux Pumps Mediate Chloramphenicol Resistance in Streptomyces coelicolor

2009 ◽  
Vol 53 (11) ◽  
pp. 4673-4677 ◽  
Author(s):  
James J. Vecchione ◽  
Blair Alexander ◽  
Jason K. Sello
Keyword(s):  
Efflux Pump ◽  
Streptomyces Coelicolor ◽  
Efflux Pumps ◽  
Major Facilitator Superfamily ◽  
Close Relative ◽  
Gram Positive ◽  
Antibacterial Drugs ◽  
Chloramphenicol Resistance ◽  
Drug Activity ◽  
Major Facilitator

ABSTRACT Chloramphenicol, florfenicol, and thiamphenicol are used as antibacterial drugs in clinical and veterinary medicine. Two efflux pumps of the major facilitator superfamily encoded by the cmlR1 and cmlR2 genes mediate resistance to these antibiotics in Streptomyces coelicolor, a close relative of Mycobacterium tuberculosis. The transcription of both genes was observed by reverse transcription-PCR. Disruption of cmlR1 decreased the chloramphenicol MIC 1.6-fold, while disruption of cmlR2 lowered the MIC 16-fold. The chloramphenicol MIC of wild-type S. coelicolor decreased fourfold and eightfold in the presence of reserpine and Phe-Arg-β-naphthylamide, respectively. These compounds are known to potentiate the activity of some antibacterial drugs via efflux pump inhibition. While reserpine is known to potentiate drug activity against gram-positive bacteria, this is the first time that Phe-Arg-β-naphthylamide has been shown to potentiate drug activity against a gram-positive bacterium.

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