Manipulation of the Avian Genome

2019 ◽  
Author(s):  
Robert J. Etches ◽  
Ann M. Gibbins
Keyword(s):  
Avian Genome

Genetically engineered birds; pre-CRISPR and CRISPR era

2021 ◽  
Author(s):  
Nima Dehdilani ◽  
Sara Yousefi Taemeh ◽  
Lena Goshayeshi ◽  
Hesam Dehghani
Keyword(s):  
Genome Engineering ◽  
Genetically Engineered ◽  
Biopharmaceutical Industry ◽  
Avian Genome ◽  
Genome Manipulation ◽  
Broad Overview

Abstract Generating biopharmaceuticals in genetically engineered bioreactors continues to reign supreme. Hence, genetically engineered birds have attracted considerable attention from the biopharmaceutical industry. Fairly recent genome engineering methods have made genome manipulation an easy and affordable task. In this review, we first provide a broad overview of the approaches and main impediments ahead of generating efficient and reliable genetically engineered birds, and various factors that affect the fate of a transgene. This section provides an essential background for the rest of the review, in which we discuss and compare different genome manipulation methods in the pre-CRISPR and CRISPR era in the field of avian genome engineering.

Origin of avian genome size and structure in non-avian dinosaurs

Nature ◽  
2007 ◽  
Vol 446 (7132) ◽  
pp. 180-184 ◽  
Author(s):  
Chris L. Organ ◽  
Andrew M. Shedlock ◽  
Andrew Meade ◽  
Mark Pagel ◽  
Scott V. Edwards
Keyword(s):  
Genome Size ◽  
Avian Genome ◽  
Size And Structure

scholarly journals Avian genome evolution: insights from a linkage map of the blue tit (Cyanistes caeruleus)

Heredity ◽  
2009 ◽  
Vol 104 (1) ◽  
pp. 67-78 ◽  
Author(s):  
B Hansson ◽  
M Ljungqvist ◽  
D A Dawson ◽  
J C Mueller ◽  
J Olano-Marin ◽  
...  
Keyword(s):  
Linkage Map ◽  
Genome Evolution ◽  
Blue Tit ◽  
Cyanistes Caeruleus ◽  
Avian Genome

The avian genome uncovered

2005 ◽  
Vol 20 (4) ◽  
pp. 180-186 ◽  
Author(s):  
H ELLEGREN
Keyword(s):  
Avian Genome

Manipulating the Avian Genome

2002 ◽  
Vol 13 (3) ◽  
pp. 169-173
Author(s):  
Robert J. Etches
Keyword(s):  
Avian Genome

scholarly journals Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2131
Author(s):  
Veronika Krchlíková ◽  
Tomáš Hron ◽  
Martin Těšický ◽  
Tao Li ◽  
Jiří Hejnar ◽  
...  
Keyword(s):  
Negative Selection ◽  
Gene Loss ◽  
Evolutionary Perspective ◽  
Compensatory Evolution ◽  
Danger Signals ◽  
Downstream Signaling ◽  
Interferon Stimulated Genes ◽  
Avian Genome ◽  
I Gene ◽  
Inducible Gene

Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5). Their activation establishes an antiviral state by downstream signaling that ultimately activates interferon-stimulated genes (ISGs). While in rare cases RIG-I gene loss has been detected in mammalian and avian species, most notably in the chicken, MDA5 pseudogenization has only been detected once in mammals. We have screened over a hundred publicly available avian genome sequences and describe an independent disruption of MDA5 in two unrelated avian lineages, the storks (Ciconiiformes) and the rallids (Gruiformes). The results of our RELAX analysis confirmed the absence of negative selection in the MDA5 pseudogene. In contrast to our prediction, we have shown, using multiple dN/dS-based approaches, that the MDA5 loss does not appear to have resulted in any compensatory evolution in the RIG-I gene, which may partially share its ligand-binding specificity. Together, our results indicate that the MDA5 pseudogenization may have important functional effects on immune responsiveness in these two avian clades.

scholarly journals A genome‐wide linkage map for the house sparrow ( Passer domesticus ) provides insights into the evolutionary history of the avian genome

2020 ◽  
Vol 20 (2) ◽  
pp. 544-559 ◽  
Author(s):  
Ingerid J. Hagen ◽  
Sigbjørn Lien ◽  
Anna M. Billing ◽  
Tore O. Elgvin ◽  
Cassandra Trier ◽  
...  
Keyword(s):  
Linkage Map ◽  
Evolutionary History ◽  
House Sparrow ◽  
Passer Domesticus ◽  
Genome Wide ◽  
A Genome ◽  
Avian Genome ◽  
History Of
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