When Do Late Effects in Childhood Cancer Survivors Cease Emerging? The Endocrine Answer

2016 ◽  
Vol 34 (27) ◽  
pp. 3231-3232
Author(s):  
Mark L. Greenberg
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors

Quality of life in long-term childhood cancer survivors and the relation of late effects and subjective well-being

2004 ◽  
Vol 13 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Sigrid Pemberger ◽  
Reinhold Jagsch ◽  
Eva Frey ◽  
Rosemarie Felder-Puig ◽  
Helmut Gadner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Well Being ◽  
Childhood Cancer Survivors ◽  
Subjective Well Being

Neurocognitive Outcomes in Childhood Cancer: Effects of Disease and Treatment on Brain Development and Learning

2010 ◽  
Author(s):  
F. Daniel Armstrong ◽  
Maria L. Goldman
Keyword(s):  
Survival Rate ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Childhood Cancer ◽  
Posttraumatic Stress ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Related Quality ◽  
Cns Cancer ◽  
Receive Treatment

Childhood cancer is a rare disease, accounting for only 1% of all malignancies in humans of all ages. In 2007, approximately 10,400 new cases of cancer were diagnosed in children 14 years of age and younger (American Cancer Society 2007). Significant advances in diagnostic techniques and tailored treatments during the past three decades have increased the 5-year survival rate for all cancers to over 80% (Twombly 2007). For acute lymphoblastic leukemia (ALL), the most common form of childhood cancer, the current survival rate is approaching 90% (Pui and Howard 2008). Better survival has led to increased awareness and focus on the consequences of cancer treatment, called late effects. The Children’s Oncology Group has developed and published guidelines for monitoring childhood cancer survivors for late effects in nearly every organ system (Landier et al. 2004), with a recent growing interest in those affecting cognitive, academic, social, and behavioral function (Nathan et al. 2007), which are the focus of this chapter. It was long assumed that a cancer diagnosis and the severe toxicity associated with treatment was such a traumatic event that significant adverse psychological consequences were inevitable. Recent, large reports from the Childhood Cancer Survivorship Study and reviews of smaller studies suggest that this is not the case for the majority of children and adolescents treated for and surviving cancer (Eiser, Hill, and Vance 2000; Zebrack et al. 2002; Zeltzer et al. 2009). With the exception of children who experience central nervous system (CNS) cancer or cancer treatment (Zebrack et al. 2004), most childhood cancer survivors are not significantly different from the general population on measures of depression (Phipps and Srivastava 1999), selfesteem (Noll et al. 1999), hopefulness (Ritchie 2001), or posttraumatic stress disorder (PTSD). Some children experience symptoms of posttraumatic stress during acute treatment, but these symptoms diminish over time (Phipps et al. 2006). For children with CNS cancer or who receive treatment that affects the CNS, the picture is somewhat different, with poorer emotional and social functioning, neurocognitive function, and overall health-related quality of life (HRQL) reported in this subpopulation (Calaminus et al. 2000; Vannatta et al. 2007).

Upfront Therapies and Downstream Effects: Navigating Late Effects in Childhood Cancer Survivors in the Current Era

2019 ◽  
Vol 21 (12) ◽  
Author(s):  
Rachel Phelan ◽  
Hesham Eissa ◽  
Kerri Becktell ◽  
Neel Bhatt ◽  
Matthew Kudek ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Downstream Effects

Endocrine Late Effects in Childhood Cancer Survivors

2018 ◽  
Vol 36 (21) ◽  
pp. 2153-2159 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Laurie E. Cohen ◽  
Sogol Mostoufi-Moab ◽  
Briana C. Patterson ◽  
Jill H. Simmons ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Mineral Density ◽  
Pituitary Dysfunction ◽  
Previously Treated ◽  
Latency Interval ◽  
Improve Health ◽  
Endocrine Complications

Endocrine complications are highly prevalent in childhood cancer survivors. Approximately 50% of survivors will experience at least one hormonal disorder over the course of their lives. Endocrine complications often are observed in survivors previously treated with radiation to the head, neck, or pelvis. We provide an overview the most common endocrine late effects seen in survivors, including hypothalamic-pituitary dysfunction, primary thyroid dysfunction, obesity, diabetes mellitus, metabolic syndrome, and decreased bone mineral density. Primary gonadal injury is discussed elsewhere in this series. Given a variable latency interval, a systematic approach where individuals are periodically screened on the basis of their risk factors can help to improve health outcomes by prompt diagnosis and treatment of evolving endocrinopathies. These recommendations must be revised in the future given changes and improvements in cancer treatment over time.

Late effects and quality of life of childhood cancer survivors: Part 1. Impact of stem cell transplantation

2010 ◽  
Vol 91 (5) ◽  
pp. 865-876 ◽  
Author(s):  
Yasushi Ishida ◽  
Misato Honda ◽  
Shuichi Ozono ◽  
Jun Okamura ◽  
Keiko Asami ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cell Transplantation ◽  
Late Effects ◽  
Childhood Cancer Survivors

Incidence of late effects in long-term childhood cancer survivors.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e22009-e22009
Author(s):  
Ronica H. Nanda ◽  
Rohit Gunan Ganju ◽  
Mary M Batcha ◽  
Natia Esiashvili
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors

Knowledge of diagnosis, treatment history, and risk of late effects among childhood cancer survivors and parents: The impact of a survivorship clinic

2015 ◽  
Vol 62 (8) ◽  
pp. 1444-1451 ◽  
Author(s):  
Robert B. Lindell ◽  
Shannon J. Koh ◽  
JoAnn M. Alvarez ◽  
Tatsuki Koyama ◽  
Adam J. Esbenshade ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Treatment History ◽  
The Impact

Looking for trouble: Adherence to late-effects surveillance among childhood cancer survivors

2016 ◽  
Vol 64 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Marina L. Reppucci ◽  
Charles L. Schleien ◽  
Jonathan D. Fish
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors
Sign in / Sign up

Export Citation Format

Share Document