Malignant Transformation of a Serous Borderline Tumor and Early Metastasis of Associated Low-Grade Serous Carcinoma Detected on Screening Mammography

2011 ◽  
Vol 29 (30) ◽  
pp. e763-e765 ◽  
Author(s):  
Donata Rohsbach ◽  
Fabian Trillsch ◽  
Marc Regier ◽  
Matthias Choschzick ◽  
Friedrich Kommoss ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Screening Mammography ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Early Metastasis ◽  
Serous Borderline Tumor

scholarly journals Case Report: Borderline tumor and primary peritoneal carcinoma - a rare synchronism

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1630
Author(s):  
Mariana Rei ◽  
Sofia Raposo ◽  
Paulo Figueiredo ◽  
Rita Sousa ◽  
Luís Sá
Keyword(s):  
Tumor Biology ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
High Grade ◽  
Peritoneal Carcinoma ◽  
Non Invasive ◽  
Serous Borderline Tumor ◽  
And Behavior ◽  
Serous Tumors

Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, the latter also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.

MR imaging findings of low-grade serous carcinoma of the ovary: comparison with serous borderline tumor

2020 ◽  
Vol 38 (8) ◽  
pp. 782-789
Author(s):  
Masaya Kawaguchi ◽  
Hiroki Kato ◽  
Yuichiro Hatano ◽  
Hiroyuki Tomita ◽  
Akira Hara ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Imaging Findings ◽  
Serous Borderline Tumor ◽  
Carcinoma Of The Ovary

scholarly journals Case Report: Borderline tumor and primary peritoneal carcinoma - a rare synchronism

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1630
Author(s):  
Mariana Rei ◽  
Sofia Raposo ◽  
Paulo Figueiredo ◽  
Rita Sousa ◽  
Luís Sá
Keyword(s):  
Tumor Biology ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
High Grade ◽  
Peritoneal Carcinoma ◽  
Non Invasive ◽  
Serous Borderline Tumor ◽  
And Behavior ◽  
Serous Tumors

Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.

A Micropapillary Variant of Transitional Cell Carcinoma Arising in the Ureter

2000 ◽  
Vol 124 (9) ◽  
pp. 1347-1348 ◽  
Author(s):  
Russell Vang ◽  
Jacki Abrams
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Inflammatory Cells ◽  
World Health ◽  
Serous Carcinoma ◽  
Ureteral Stricture ◽  
Borderline Tumor ◽  
Nephrogenic Adenoma ◽  
Serous Borderline Tumor

Abstract A 79-year-old woman was evaluated for a ureteral stricture related to laser ablation of a tumor 6 months earlier at another institution. A ureteroscopic examination revealed an exophytic papillary tumor that was resected and examined histologically. The tumor was characterized by delicate papillae with thin stromal cores and numerous secondary micropapillae lined by small cuboidal to low columnar cells with uniform low-to-intermediate–grade nuclei, reminiscent of a serous borderline tumor of müllerian origin. The cell linings were 1 to 4 layers thick; mitotic figures were easily identified. The underlying stroma appeared edematous and contained scattered chronic inflammatory cells. No invasion was identified. After ascertaining that the patient had no known gynecologic neoplasm, the differential diagnoses considered included papillary nephrogenic adenoma, clear cell carcinoma, and the recently described entity of micropapillary transitional cell carcinoma. Because of the striking resemblance to serous carcinoma and the presence of significant mitotic activity, this case was felt to represent a case of micropapillary transitional cell carcinoma (World Health Organization grade 1 to 2) occurring in the ureter. To our knowledge, this tumor had some unique features (no areas of grade 3 nuclei or invasion) that have not been reported in tumors occurring in the urinary bladder. The transitional cell nature of the tumor cells was supported by the immunohistochemical staining pattern. The anatomic distribution of micropapillary transitional cell carcinoma is now expanded to include the ureter, and this tumor should be considered in the differential diagnosis for papillary lesions occurring in the ureter.

Diagnostic Discordance in Intraoperative Frozen Section Diagnosis of Ovarian Tumors: A Literature Review and Analysis of 871 Cases Treated at a Japanese Cancer Center

2020 ◽  
pp. 106689692096051
Author(s):  
Hiroshi Yoshida ◽  
Hiroki Tanaka ◽  
Takafumi Tsukada ◽  
Naoko Abeto ◽  
Mayumi Kobayashi-Kato ◽  
...  
Keyword(s):  
Literature Review ◽  
Frozen Section ◽  
Malignant Potential ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Mucinous Tumor ◽  
Ovarian Metastases ◽  
Frozen Section Diagnosis

Background This study examined the accuracy and pitfalls associated with frozen section diagnosis of primary ovarian tumors and ovarian metastases based on the 2014 World Health Organization classification (WHO) criteria and proposed improvements from a pathologist’s perspective. Methods We microscopically reviewed 871 cases of primary ovarian tumor (N = 802) and ovarian metastasis (N = 69) and compared the results of frozen sections with the final diagnosis. Malignant potential concordance (benign, borderline, or malignant) and specific discordant diagnosis rates were analyzed. Finally, we conducted a unique literature review of specific diagnostic errors in the frozen section diagnosis of primary ovarian tumors. Results Of 802 primary ovarian tumors, 50 (6.2%) cases showed discordant diagnoses in which mucinous carcinoma (40.5%), low-grade serous carcinoma (LGSC; 31.3%), and mucinous borderline tumor (18.4%) were frequently misinterpreted. Of 69 ovarian metastases, all 4 cases of low-grade appendiceal mucinous neoplasm (LAMN) were misdiagnosed as primary ovarian mucinous tumor. A literature review revealed that mucinous/serous borderline tumor or carcinoma accounted for approximately 70% of 217 reported discordant diagnoses. Conclusion In the present study, the concordance rate of malignant potential of the tumor was comparable to that previously reported. Even in the 2014 WHO classification, primary ovarian mucinous borderline tumor/carcinoma and LGSC still comprised the majority of discordant cases. Grossing methods that reduce sampling error are required. LAMN was frequently misinterpreted as a benign or borderline ovarian mucinous tumor. To prevent this error, a differential algorithm integrating clinical information and gross findings should be developed.

scholarly journals A Rare Case of Ovarian Serous Borderline Tumor with Brain Metastasis

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sonia Veran-Taguibao ◽  
Roberto Alvaro A. Taguibao ◽  
Nicolas Gallegos ◽  
Ted Farzaneh ◽  
Ronald Kim ◽  
...  
Keyword(s):  
Ovarian Tumor ◽  
Serous Cystadenoma ◽  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Younger Women ◽  
Excellent Outcome ◽  
Serous Borderline Tumor ◽  
Stage 1 ◽  
The Brain ◽  
Micropapillary Pattern

Background. Serous borderline tumor represents a group of noninvasive tumor of the ovary bridging between benign serous cystadenoma and serous carcinoma. They are commonly seen in younger women and usually have an excellent outcome but seldom show local recurrence (J. F. Leake et al. 1991). Metastasis to the lymph nodes has rarely been reported (M. D. Chamberlin et al., 2001; M. B. Verbruggen et al., 2006). Moreover, the brain is exceptionally a rare metastatic site for ovarian tumor. There is one case of an advanced staged SBT with micropapillary pattern metastasis to the brain recently and by far it is the most distant metastasis reported (M. D. Martin et al., 2017). However, to the best of our knowledge, no report has been documented for a recurrent stage 1 typical SBT metastasizing to the brain.

scholarly journals Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma

2019 ◽  
Vol 43 (11) ◽  
pp. 1462-1472 ◽  
Author(s):  
Michael Herman Chui ◽  
Deyin Xing ◽  
Felix Zeppernick ◽  
Zoe Q. Wang ◽  
Charlotte G. Hannibal ◽  
...  
Keyword(s):  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Serous Borderline Tumor ◽  
Molecular Features
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