Angiotensin Receptor Blockade and Risk of Cancer in Type 2 Diabetes Mellitus: A Nationwide Case-Control Study

2011 ◽  
Vol 29 (22) ◽  
pp. 3001-3007 ◽  
Author(s):  
Chia-Hsuin Chang ◽  
Jou-Wei Lin ◽  
Li-Chiu Wu ◽  
Mei-Shu Lai
Keyword(s):  
Cancer Incidence ◽  
Case Control Study ◽  
Angiotensin Receptor Blockers ◽  
Case Control ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Angiotensin Receptor ◽  
Incident Cancer ◽  
Risk Of Cancer ◽  
Control Study

Purpose The objective of this case-control study was to evaluate the risk of malignancy in diabetic patients who received angiotensin receptor blockers (ARBs). Patients and Methods A total of 21,750 new diabetic patients who started antihypertensive treatment were identified from the Taiwan National Health Insurance claims database during the period from July 1, 2000, to December 31, 2000. As of December 31, 2007, patients with incident cancer were included as cases and up to four age- and sex-matched controls were selected by risk-set sampling. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% CIs between ARB use and cancer incidence, adjusted for other types of antihypertensive drugs, insulin, oral hypoglycemic agents, statins, and underlying diseases. Results Among the 1,281 patients with incident cancer and 5,104 controls, 333 (26.0%) and 1,341 (26.3%), respectively, received ARBs (OR, 0.98; 95% CI, 0.85 to 1.14). There was no statistically significant association between the effect of ARBs as a class and cancer incidence after adjustment for covariates (OR, 0.94; 95% CI, 0.80 to 1.10). Among the individual ARBs, losartan decreased the risk (OR, 0.78; 95% CI, 0.63 to 0.97) and candesartan (OR, 1.79; 95% CI, 1.05 to 3.06) and telmisartan (OR, 1.54; 95% CI, 0.97 to 2.43) possibly increased the risk of occurrence of malignancy. Conclusion The results did not show an effect of ARBs as a class on increasing cancer incidence in patients with diabetes. However, there was a negative association of losartan but a positive one of candesartan and telmisartan with the overall occurrence of cancer. The underlying mechanism certainly requires further investigation.

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

2020 ◽  
Vol 76 (5) ◽  
pp. 304-312
Author(s):  
Tengfei Lin ◽  
Chonglei Bi ◽  
Yun Song ◽  
Huiyuan Guo ◽  
Lishun Liu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Smoking Status ◽  
Controlled Trial ◽  
Case Control ◽  
Cancer Site ◽  
Incident Cancer ◽  
Plasma Magnesium ◽  
Nested Case Control ◽  
Risk Of Cancer ◽  
Control Study

<b><i>Objective:</i></b> The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. <b><i>Methods:</i></b> A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. <b><i>Results:</i></b> When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (&#x3c;0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33–5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12–3.76), compared with those in quartile 3 (0.83 to &#x3c;0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. <b><i>Conclusions:</i></b> Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to &#x3c;0.89 mmol/L among hypertensive adults.

scholarly journals Impact of Glucose-Lowering Agents on the Risk of Cancer in Type 2 Diabetic Patients. The Barcelona Case-Control Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79968 ◽  
Author(s):  
Rafael Simó ◽  
Oleguer Plana-Ripoll ◽  
Diana Puente ◽  
Rosa Morros ◽  
Xavier Mundet ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Glucose Lowering ◽  
Risk Of Cancer ◽  
Type 2 Diabetic ◽  
Control Study

Starchy Foods and Risk of Cancer of the Upper Aerodigestive Tract: A Case-control Study in Uruguay

2000 ◽  
pp. 27-30
Author(s):  
Eduardo De Stefani ◽  
Paolo Boffetta ◽  
Fernando Oreggia ◽  
Alvaro Ronco ◽  
Hugo Deneo-Pellegrini ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Risk Of Cancer ◽  
Starchy Foods ◽  
Control Study

scholarly journals Risk of latent tuberculosis infection among diabetic patients in Azadi Teaching Hospital, Duhok province: a case control study

2018 ◽  
Vol 4 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Muayad A Merza ◽  
Abdul Aziz Sulaiman Savo ◽  
Muhammad Jaafer
Keyword(s):  
Diabetes Mellitus ◽  
Teaching Hospital ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Previous Hospitalization ◽  
Control Study

Diabetes can be linked with impaired host immunity that subsequently increases the rate of various infections including tuberculosis (TB), particularly in developing countries where TB is endemic. The objectives of this case control study were to determine the prevalence and the risk of LTBI among diabetic patients. It is a prospective case control study conducted in Azadi Teaching Hospital from September 2017 until May 2018. The diabetic patients included in this study were randomly selected. The diagnosis of diabetes mellitus (DM) was made according to the American Diabetes Association (ADA). Diabetes mellitus patients and the control participants were offered a voluntary tuberculin skin test (TST). The TST ≥10 mm was considered positive. The results were analyzed by entering the data in SPSS (statistical package for the social sciences, version 16; SPSS Inc., Chicago, Illinois, USA). Two hundred DM patients and 208 control individuals participated in this study. Collectively, 28 patients had positive TST results. Based on the sputum smear microscopy and CXR, none of these patients showed active TB disease. The differences between the DM patients and the control group had no statistical significance apart from previous hospitalization. The prevalence of LTBI was 23.53% in the diabetic group, whereas, it was 9.62% in the control group. The frequency of LTBI in diabetic patients was significantly higher than the control group. When the diabetic group was compared with the control group in terms of diabetic control and the duration of diabetes disease, there was a statistically significant association of diabetes duration ≥ 10 years and TST positivity. In conclusion, the previous hospitalization was a significant risk factor for diabetic patients to acquire TB bacilli. Latent TB infection was more common in diabetics than non diabetics and there was an increased likelihood of having LTBI with the duration of diabetes ≥ 10 years. To avoid the threatening of TB control program, prophylactic treatment of LTBI in diabetic patients is paramount.Asian J. Med. Biol. Res. June 2018, 4(2): 227-232

CMV plasma DNAemia and risk of cancer among HIV-infected patients: A case–control study nested in the ANRS CO3 Aquitaine Cohort, France, 2002–2007

2011 ◽  
Vol 50 (2) ◽  
pp. 177-180
Author(s):  
Mathias Bruyand ◽  
Marie-Anne Vandenhende ◽  
Guillaume Marcel ◽  
Estibaliz Lazaro ◽  
Marie-Edith Lafon ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Risk Of Cancer ◽  
Control Study

scholarly journals Risk factors associated with peripheral neuropathy among diabetic individuals: a case control study

2021 ◽  
Vol 8 (2) ◽  
pp. 768
Author(s):  
Christa Kingston ◽  
Aravindan J. ◽  
Srikumar Walsalam
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Diabetic Neuropathy ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Factors Associated ◽  
History Of ◽  
Control Study

Background: Diabetic neuropathy is one among the most common complication in diabetes mellitus. Diabetic peripheral neuropathy hinders the quality of life causing morbidity and mortality. The purpose of this study was to find the risk factors associated with diabetic neuropathy.Methods: This case control study involved 100 diabetic patients attending the Dohnavur fellowship hospital, Dohnavur from October 2019 to March 2020. Sociodemographic profile and diabetic characteristics of the study group were obtained and analysed. Diagnosis of Diabetic Neuropathy was done by using the diagnostic method proposed by American Diabetic Association.Results: Of the total study population with mean age 59.43 years, 63% had family history of diabetes. Almost 70% had poor diabetic control. Statistically significant relationships were found between neuropathy and duration of diabetes, glycaemic control, history of hypertension, monofilament test and pinprick sensation.Conclusions: In this study, glycemic control, dyslipidemia and hypertension were modifiable risk factors for diabetic neuropathy. Early interventional programs to sensitize diabetics on these factors could improve the quality of life of Diabetic patients. 

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