Impact of Prediagnosis Smoking, Alcohol, Obesity, and Insulin Resistance on Survival in Male Cancer Patients: National Health Insurance Corporation Study

2006 ◽  
Vol 24 (31) ◽  
pp. 5017-5024 ◽  
Author(s):  
Sang Min Park ◽  
Min Kyung Lim ◽  
Soon Ae Shin ◽  
Young Ho Yun
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Head And Neck ◽  
Cancer Patients ◽  
National Health ◽  
Cancer Survival ◽  
Serum Glucose ◽  
Mortality Data ◽  
Health Examination ◽  
Fasting Serum Glucose Level

PurposeAlthough many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied.Patients and MethodsThe study participants were 14,578 men with a first cancer derived from a cohort of 901,979 male government employees and teachers who participated in a national health examination program in 1996. We obtained mortality data for those years from the Korean Statistical Office. We used a standard Poisson regression model to estimate the hazard ratio (HR) for survival in relation to smoking, alcohol, obesity, and insulin resistance before diagnosis.ResultsPoor survival of all cancer combined (HR, 1.24; 95% CI, 1.16 to 1.33), cancer of the lung (HR, 1.45; 95% CI, 1.15 to 1.82), and cancer of the liver (HR, 1.36; 95% CI, 1.21 to 1.53) were significantly associated with smoking. Compared with the nondrinker, heavy drinkers had worse outcomes for head and neck (HR, 1.85; 95% CI, 1.23 to 2.79) and liver (HR, 1.25; 95% CI, 1.11 to 1.41) cancer, with dose-dependent relationships. Patients with a fasting serum glucose level above 126 mg/dL had a higher mortality rate for stomach (HR, 1.52; 95% CI, 1.25 to 1.84) and lung (HR, 1.48; 95% CI, 1.18 to 1.87) cancer. Higher body mass index was significantly associated with longer survival in head and neck (HR, 0.54; 95% CI, 0.39 to 0.74) and esophagus (HR, 0.44; 95% CI, 0.28 to 0.68) cancer.ConclusionPrediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.

Prediagnosis Smoking, Obesity, Insulin Resistance, and Second Primary Cancer Risk in Male Cancer Survivors: National Health Insurance Corporation Study

2007 ◽  
Vol 25 (30) ◽  
pp. 4835-4843 ◽  
Author(s):  
Sang Min Park ◽  
Min Kyung Lim ◽  
Kyu Won Jung ◽  
Soon Ae Shin ◽  
Keun-Young Yoo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Health Insurance ◽  
Cancer Survivors ◽  
National Health Insurance ◽  
National Health ◽  
Smoking History ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Purpose Smoking, obesity, and insulin resistance are well-known risk factors for cancer, yet few epidemiology studies evaluate their role as risk factors for a second primary cancer (SPC). Patients and Methods We identified 14,181 men with a first cancer from the National Health Insurance Corporation Study cohort. We obtained data on fasting glucose level, body mass index (BMI), and smoking history from an enrollment interview (1996). We obtained SPC incidence data for 1996 through 2002 from the Korean Central Cancer Registry. We used the standard Poisson regression model to estimate the age- and multivariate-adjusted relative risk (RR) for SPCs in relation to smoking history, BMI, and insulin resistance before diagnosis. Results We observed 204 patients with SPC. The overall age-standardized incidence rate of SPC was 603.2 occurrences per 100,000 person-years, which was about 2.3 times higher than that of first cancer in the general male population. Multivariate regression revealed that lung (RR, 3.69; 95% CI, 1.35 to 10.09) and smoking-related (RR, 2.02; 95% CI, 1.02 to 4.03) SPCs were significantly associated with smoking. Obese patients (BMI ≥ 25 kg/m2) had significantly elevated RRs for colorectal (RR, 3.45; 95% CI, 1.50 to 7.93) and genitourinary (RR, 3.61; 95% CI, 1.36 to 9.54) SPCs. Patients with a fasting serum glucose concentration ≥ 126 mg/dL had a higher RR for hepatopancreatobiliary (RR, 3.33; 95% CI, 1.33 to 8.37) and smoking-related (1.93; 95% CI, 1.01 to 3.68) SPCs. Conclusion Prediagnosis smoking history, obesity, and insulin resistance were risk factors for several SPCs. These findings suggest that more thorough surveillance and screening for SPCs is needed for the cancer survivors with these risk factors.

scholarly journals Exploration of risk factors for weight loss in head and neck cancer patients

2015 ◽  
Vol 14 (4) ◽  
pp. 343-352 ◽  
Author(s):  
Patrick Dawson ◽  
Amy Taylor ◽  
Chris Bragg
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Weight Loss ◽  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Linear Regression Analysis ◽  
Relative Significance

AbstractIntroductionHead and neck cancer patients receiving radiotherapy can experience a number of toxicities, including weight loss and malnutrition, which can impact upon the quality of treatment. The purpose of this retrospective cohort study is to evaluate weight loss and identify predictive factors for this patient group.Materials and methodsA total of 40 patients treated with radiotherapy since 2012 at the study centre were selected for analysis. Data were collected from patient records. The association between potential risk factors and weight loss was investigated.ResultsMean weight loss was 5 kg (6%). In all, 24 patients lost >5% starting body weight. Age, T-stage, N-stage, chemotherapy and starting body weight were individually associated with significant differences in weight loss. On multiple linear regression analysis age and nodal status were predictive.ConclusionYounger patients and those with nodal disease were most at risk of weight loss. Other studies have identified the same risk factors along with several other variables. The relative significance of each along with a number of other potential factors is yet to be fully understood. Further research is required to help identify patients most at risk of weight loss; and assess interventions aimed at preventing weight loss and malnutrition.

Role of prophylactic PEG and risk factors for PEG dependency in head and neck cancer patients undergoing radiotherapy.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e17017-e17017
Author(s):  
Ruchika Gutt ◽  
Steven H. Krasnow ◽  
Hosai Hesham ◽  
Andrea Burmeister ◽  
JoAnn Manning
Keyword(s):  
Risk Factors ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer

scholarly journals Incidence and Risk Factors of Hypomagnesemia in Head and Neck Cancer Patients Treated with Cetuximab

2016 ◽  
Vol 6 ◽  
Author(s):  
Tomohiro Enokida ◽  
Shinya Suzuki ◽  
Tetsuro Wakasugi ◽  
Tomoko Yamazaki ◽  
Susumu Okano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer

scholarly journals Prevalence and Management of Diabetes and Associated Risk Factors by Regions of Thailand: Third National Health Examination Survey 2004

Diabetes Care ◽  
2007 ◽  
Vol 30 (8) ◽  
pp. 2007-2012 ◽  
Author(s):  
W. Aekplakorn ◽  
J. Abbott-Klafter ◽  
A. Premgamone ◽  
B. Dhanamun ◽  
C. Chaikittiporn ◽  
...  
Keyword(s):  
Risk Factors ◽  
National Health ◽  
Health Examination ◽  
Health Examination Survey ◽  
Associated Risk Factors

A historical review of head and neck cancer in celebrities

2006 ◽  
Vol 121 (6) ◽  
pp. 511-520 ◽  
Author(s):  
B J Folz ◽  
A Ferlito ◽  
N Weir ◽  
L W Pratt ◽  
A Rinaldo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Medical Literature ◽  
Public Awareness ◽  
Historical Review ◽  
Term Survival

Introduction: The illnesses of celebrity patients always receive more attention from the general public than those of ordinary patients. With regard to cancer, this fact has helped to spread information about the four major malignancies: breast cancer, prostatic cancer, lung cancer and colorectal cancer. Head and neck cancer, on the other hand, is still not well recognised by the lay public, although the risk factors are similar to those of lung cancer. It was the objective of this analysis to identify cases of celebrity patients, the description of which could help to increase awareness of head and neck cancer, its symptoms and risk factors.Methods: The Internet and medical literature databases were searched for celebrity patients who had suffered from head and neck cancer.Results: The search revealed numerous famous head and neck cancer patients. However, only seven cases were documented well in the medical literature. Among the identified persons were one emperor, two United States presidents, a legendary composer, a world-renowned medical doctor, an outstanding athlete and an extraordinary entertainer. In spite of their exclusive position in society, these patients did not have a better prognosis compared with ordinary patients of their time. Only two of the group experienced long term survival and only one was cured. None of these influential figures used their influence to fund research or to promote knowledge about their respective diseases.Conclusion: The identified cases could help increase public awareness of head and neck cancer. Similar to activities in other oncologic fields, current celebrity head and neck cancer patients should be encouraged to discuss their diseases openly, which could have a positive effect on public health.

The Association of Adolescent Fatness and Fitness With Risk Factors for Adult Metabolic Syndrome: A 22-Year Follow-up Study

2014 ◽  
Vol 11 (4) ◽  
pp. 823-830 ◽  
Author(s):  
Yoonsuk Jekal ◽  
YoonMyung Kim ◽  
Ji Eun Yun ◽  
Eun Sung Kim ◽  
Masayo Naruse ◽  
...  
Keyword(s):  
Risk Factors ◽  
High School ◽  
Metabolic Syndrome ◽  
Health Insurance ◽  
National Health Insurance ◽  
National Health ◽  
Health Examination ◽  
Follow Up Study ◽  
Fitness Levels

Background:Few studies have been conducted to explore the associations of fatness and fitness during adolescence with risk factors of metabolic syndrome (MetS) during adulthood, particularly in Asians.Methods:Adolescent anthropometric and fitness data were collected during the participants’ high school years (N = 15,896) and their corresponding health examination data from adulthood were taken from the National Health Insurance Corporation (NHIC) in Korea. A total of 1,006 participants (6.3%) were analyzed in the study.Results:The odds ratios (ORs) for being overweight (BMI ≥ 25 kg/m2) during adulthood was 11.87 (95% CI: 4.19–33.59) in men and 8.44 (95% CI: 1.78–40.02) in women, respectively, in the fattest group vs. the leanest group during adolescence. Participants with low fitness levels during adolescence were more likely to be overweight and have abnormal MetS risk factors in adulthood vs. those with high fitness levels. Joint exposure analyses of fatness and fitness showed that male participants who were more fat and unfit during adolescence had 4.11 (95% CI: 1.19–14.14) and 3.04 (95% CI: 1.17–11.12) times higher risk of having abnormal glucose and MetS risks during adulthood, respectively.Conclusions:Fatness and fitness levels during adolescence appear to be significantly associated with the MetS risk factors and prevalence in adulthood in Koreans.

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