Blood Pressure and Body Mass Index in Long-Term Survivors of Testicular Cancer

2005 ◽  
Vol 23 (22) ◽  
pp. 4980-4990 ◽  
Author(s):  
H. Sagstuen ◽  
N. Aass ◽  
S.D. Fosså ◽  
O. Dahl ◽  
O. Klepp ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Testicular Cancer ◽  
Body Mass ◽  
Healthy Controls ◽  
Treatment Groups ◽  
Surgery Group ◽  
Long Term Survivors

Purpose To evaluate blood pressure and body mass index (BMI) in long-term survivors of testicular cancer (TC) treated with different modalities. Patients and Methods One thousand eight hundred fourteen patients treated for unilateral TC in Norway (1980 to 1994) were invited to participate in a follow-up study (1998 to 2002), including measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. Of these patients, 1,289 patients (71%) participated in the study. The patients were categorized into four treatment groups: surgery (n = 242), radiotherapy (n = 547), and two chemotherapy groups, cumulative cisplatin dose ≤ 850 mg (n = 402) and cumulative cisplatin dose more than 850 mg (n = 98). A control group consisted of healthy males from the Tromsø Population Study (n = 2,847). Results At diagnosis, age-adjusted regression analyses showed no differences between the treatment groups for any variables. After a median follow-up time of 11.2 years, age-adjusted SBP and DBP were significantly higher for both chemotherapy groups compared with the surgery group. Chemotherapy-treated patients had increased odds for hypertension at follow-up compared with the surgery group, and the odds were highest for the cisplatin more than 850 mg group (odds ratio = 2.4; 95% CI, 1.4 to 4.0). The cisplatin more than 850 mg group had a significantly higher 10-year BMI increase and a higher prevalence of obesity at follow-up than the surgery group. Compared with healthy controls, chemotherapy-treated patients had, at follow-up, increased SBP, increased DBP, excessive BMI increase, and a higher prevalence of hypertension. Conclusion Five to 20 years after therapy, cured TC patients treated with cisplatin-based chemotherapy had significantly higher levels of blood pressure, a higher prevalence of hypertension, and an excessive weight gain compared with patients treated with other modalities and compared with healthy controls.

scholarly journals Association between change in cardiorespiratory fitness and incident hypertension in Swedish adults

2020 ◽  
pp. 204748732094299
Author(s):  
Tobias Holmlund ◽  
Björn Ekblom ◽  
Mats Börjesson ◽  
Gunnar Andersson ◽  
Peter Wallin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Maximal Oxygen Consumption ◽  
Risk Level ◽  
Annual Change ◽  
Incident Hypertension

Aims To explore how change in cardiorespiratory fitness is associated with incident hypertension in adults, and whether the association varies between sex, age, body mass index, cardiorespiratory fitness at baseline and follow-up time. A second aim is to study how change in other lifestyle-related variables affects the results. Methods A total of 91,728 participants (48% women), normotensive at baseline, with two examinations from occupational health service screenings between 1982 and 2019 (mean duration 4.3 years) were included. Cardiorespiratory fitness was assessed as estimated maximal oxygen consumption using submaximal cycle testing. Change in cardiorespiratory fitness was expressed as the percentage change per year. Incident hypertension was defined as systolic blood pressure of 140 mmHg or greater or diastolic blood pressure of 90 mmHg or greater, or self-reported physician-diagnosed hypertension, at second examination. Results A large increase (≥3% annual change) in cardiorespiratory fitness was associated with a 11% lower risk of incident hypertension compared with maintainers (–1 to +1%), after multi-adjustment including change in smoking, body mass index, diet, stress and exercise habits. On the contrary, a small (–1 to −<3%) and large (≥–3%) decrease in cardiorespiratory fitness associated with a 21% and 25% higher risk compared with maintainers. Longer duration between the examinations was associated with stronger risk associations. Preserving, or changing to, risk level for the other lifestyle variables was associated with a higher risk of incident hypertension. However, a simultaneous maintenance of or increase in cardiorespiratory fitness attenuated the risk associated with smoking, and stress. Conclusion Preserving or increasing cardiorespiratory fitness should be part of any long-term strategy to decrease the risk of incident hypertension.

Steeper increases in body mass index during childhood correlate with blood pressure elevation in adolescence: a long-term follow-up study in a Japanese community

2013 ◽  
Vol 37 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Erika Kuwahara ◽  
Keiko Asakura ◽  
Yuji Nishiwaki ◽  
Hirokazu Komatsu ◽  
Akemi Nakazawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Blood Pressure Elevation ◽  
Follow Up Study ◽  
Pressure Elevation ◽  
Long Term Follow Up

scholarly journals Long-Term Postoperative Total Knee Arthroplasty Flexion Scores in Relation to Body Mass Index

2020 ◽  
Author(s):  
Matthew A. Siegel ◽  
Michael J. Patetta ◽  
Angie M. Fuentes ◽  
Armaan S. Haleem ◽  
Craig W. Forsthoefel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Total Knee Arthroplasty ◽  
Body Mass ◽  
Knee Arthroplasty ◽  
Statistical Significance ◽  
P Value ◽  
Preoperative Body Mass Index ◽  
Total Knee

AbstractKnee range of motion (ROM) is an important postoperative measure of total knee arthroplasty (TKA). There is conflicting literature whether patients who are obese have worse absolute ROM outcomes than patients who are not obese. This study analyzed whether preoperative body mass index (BMI) influences knee ROM after patients' primary TKA. A retrospective investigation was performed on patients, who underwent primary TKA at an academic institution, by one of three fellowship-trained adult reconstruction surgeons. Patients were stratified according to their preoperative BMI into nonobese (BMI < 30.0 kg/m2) and obese (BMI ≥ 30.0 kg/m2) classifications. Passive ROM was assessed preoperatively as well as postoperatively at patients' most recent follow-up visit that was greater than 2 years. Mann–Whitney U tests were performed to determine statistical significance at p-value <0.05 for ROM outcomes. No statistically significant differences were observed when ROM in the nonobese group was compared with ROM in the obese group both preoperatively (105.73 ± 11.58 vs. 104.14 ± 13.58 degrees, p-value = 0.417) and postoperatively (105.83 ± 14.19 vs. 104.49 ± 13.52 degrees, p-value = 0.777). Mean follow-up time for all patients was 4.49 ± 1.92 years. In conclusion, long-term postoperative ROM outcomes were similar between patients who were nonobese and patients who were obese.

Physiological persona differences based on stress and inflammation between meditators and healthy controls

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Dipti Magan ◽  
Raj Kumar Yadav
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Plasma Levels ◽  
Inflammatory Markers ◽  
Tumor Necrosis ◽  
Healthy Controls ◽  
Short Term ◽  
Tnf Α ◽  
Necrosis Factor

AbstractBackgroundNowadays, yoga is endorsed and advised routinely to stay fit and healthy, as well as control many chronic diseases including diabetes type 2, hypertension, coronary artery diseases, etc. Now, our assumption is that those who do regular yoga have different persona than who do not do yoga regularly. We planned to test our hypothesis scientifically, and therefore baseline physiological characteristics with stress and inflammation levels in long-term and short-term meditators and healthy novice controls were analyzed.MethodsIn this retrospective analysis, 97 male participants were included for their Baseline analysis. Fifteen apparently healthy subjects practicing preksha meditation (since >5 years, at least 5 days a week) were included as long-term meditators (LTMs); 58 subjects who attended one of our short-term yoga-based lifestyle intervention programs for 2 weeks were included as short-term meditators (STMs); 24 male novice subjects, who did not participate in any yogic intervention, were included as healthy controls. Here, we analyzed the Baseline plasma levels of stress and inflammatory markers, cortisol, β-endorphin, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in long-term meditators vs. short-term meditators vs. healthy controls.Outcome measuresThe study parameters body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), plasma levels of stress and immune markers, cortisol, β-endorphin (β-Ed), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), were assessed in all the three groups at baseline.ResultsSignificant (p<0.05) differences were observed at baseline for plasma levels of stress and inflammatory markers as well as body mass index and systolic blood pressure among LTM vs. STM vs. healthy controls.ConclusionsOur observations suggest that the subjects who do regular yoga-meditation practice have better stress & inflammation status than comparable age matched healthy controls.

scholarly journals Discharge Body Mass Index, Not Illness Chronicity, Predicts 6-Month Weight Outcome in Patients Hospitalized With Anorexia Nervosa

2021 ◽  
Vol 12 ◽  
Author(s):  
Graham W. Redgrave ◽  
Colleen C. Schreyer ◽  
Janelle W. Coughlin ◽  
Laura K. Fischer ◽  
Allisyn Pletch ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Body Mass ◽  
Adult Women ◽  
Short Term ◽  
Illness Duration ◽  
Weight Restoration ◽  
The Impact

Proposed treatments for severe and enduring anorexia nervosa (SE-AN) focus on quality of life, and psychological and social functioning. By de-emphasizing weight restoration as a priority, however, premature diagnosis of SE-AN may reduce potential for recovery. The present study assessed the effect of weight restoration, illness duration, and severity on treatment outcome 6 months after discharge from an intensive, meal-based behavioral treatment program. Participants included hospitalized adult women (N = 191) with AN or underweight other specified feeding and eating disorder (OSFED). Participants were characterized as short-term (ill &lt;7 years; n = 74) or long-term ill (ill ≥ 7 years; n = 117). Compared with short-term ill, long-term ill patients were older, had lower lifetime body mass index (BMI), more prior admissions, and exhibited greater depression and neuroticism. Long-term vs. short-term ill patients gained weight at the same rate (~2 kg/wk) and were equally likely to be weight restored by discharge (&gt;75% reached BMI ≥ 19 kg/m2 in both groups). At 6-month follow-up (n = 99), both groups had equivalent self-reported BMI, and depression, drive for thinness, body dissatisfaction, and bulimia scores. The only predictor of BMI ≥ 19 kg/m2 at follow-up was discharge BMI. The likelihood of a BMI ≥ 19 kg/m2 at follow-up was 5-fold higher for those with discharge BMI ≥ 19 kg/m2. Few studies of long-term ill inpatients with AN have examined the impact of full weight restoration on short-term outcomes. This study supports the therapeutically optimistic stance that, regardless of illness duration, hospitalized patients with AN benefit from gaining weight to a BMI ≥ 19 kg/m2.

Plain vitamin D or alfacalcidol as follow-up treatment of postmenopausal osteoporosis after continuous long-term once weekly bisphosphonate intake

2012 ◽  
Vol 21 (02) ◽  
pp. 83-87 ◽  
Author(s):  
E. Schacht ◽  
J. D. Ringe
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Postmenopausal Osteoporosis ◽  
Body Mass ◽  
Sich Eine ◽  
Fand Sich ◽  
Negative Effekte

ZusammenfassungEine langjährige orale Bisphosphonat (BP)– Behandlung der Osteoporose kann durch übermäßige Suppression des Knochenumbaues negative Effekte auf die Knochenqualität haben. Es gibt bislang keine verbindlichen Empfehlungen zur Anwendungsdauer der BP, aber eine Therapieunterbrechung nach etwa fünf Jahren wird heute überwiegend angeraten. Bezüglich anschließenden Folgebehandlung gibt es allerdings auch kaum publizierte wissenschaftliche Daten. Wir haben in einer zweijährigen Studie an 85 Frauen mit postmenopausaler Osteoporose nach einer mittleren BP-Einnahmedauer von 4,2 Jahren zwei verschiedene Folge behandlungen vergleichend untersucht: Gruppe A (n = 42) erhielt 800 IE natürliches Vitamin D + 1200 mg Kalzium pro Tag, Gruppe B (n = 43) 1 µg Alfacalcidol + 500 mg Kalzium pro Tag. Primärer Endpunkt war die Änderung der Knochenmineraldichte (BMD) nach 12 und 24 Monaten. Weitere Endpunkte waren neu auftretende Stürze und Frakturen, Rückenschmerz (VAS 0–10) und unerwünschte Therapieeffekte. Zwischen den beiden Gruppen bestanden keine Unterschiede in den Ausgangscharakteristika Alter, Body-Mass-Index, Größenverlust, BMD, Rückenschmerz-Score und der Anzahl vorbestehender Stürze und Frakturen. In Gruppe A änderten sich die BMD-Werte an der LWS nicht signifikant während der zwei Jahre Follow-up nach Absetzen der BPEinnahme. Dagegen zeigte sich in Gruppe B für die LWS ein signifikanter Anstieg von 2,1 % (B vs. A p < 0,01). An den zwei Femurmessorten fanden wir leichte Abnahmen in der Vitamin-D-Gruppe und einen signifikanten Anstieg unter Alfacalcidol. Die mittlere Anzahl von Stürzen pro Patient blieb unverändert in Gruppe A und nahm signifikant ab in Gruppe B (p < 0,05). Die Anzahl der Patienten mit neuen Wirbelfrakturen unterschied sich nach zwei Jahren nicht zwischen beiden Therapiegruppen, während die Inzidenz von nichtvertebralen Frakturen in der Alfacalcidol-Gruppe signifikant niedriger ausfiel (p < 0,05). Des Weiteren fand sich eine signifikant stärkere Verminderung der Rückenschmerzen bei den Patienten unter Alfacalcidol- Behandlung. Bezüglich der Häufigkeit unerwünschter Wirkungen fand sich kein Unterschied zwischen den beiden Gruppen. Die Ergebnisse zeigen, dass eine Therapieumstellung nach langzeitiger BP-Anwendung bei postmenopausaler Osteoporose auf Alfacalcidol der Nachbehandlung mit natürlichem Vitamin D überlegen ist.

Association between general and central adiposity and development of hypertension in early childhood

2019 ◽  
Vol 26 (12) ◽  
pp. 1326-1334 ◽  
Author(s):  
Maira A Ortiz-Pinto ◽  
Honorato Ortiz-Marrón ◽  
Isabel Ferriz-Vidal ◽  
María V Martínez-Rubio ◽  
María Esteban-Vasallo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
High Blood Pressure ◽  
Abdominal Obesity ◽  
Excess Weight ◽  
Weight Changes ◽  
Increased Risk ◽  
Incident Cases

Objectives To evaluate the association of general and abdominal obesity with high blood pressure in young children. Methods A longitudinal study including 1796 participants from the Madrid region (Spain) with baseline at age 4 years and a follow-up 2 years later. Blood pressure, body mass index and waist circumference were measured during a physical examination. We evaluated the association between obesity at baseline and weight changes between the ages of 4 and 6 years and high blood pressure. Data were analysed using linear and logistic regressions adjusted for covariates. Results Obese 4 year olds (general or abdominal obesity) experienced an average 4–5 mmHg increase in systolic blood pressure and a 2.5–3 mmHg increase in diastolic blood pressure by the age of 6 years. Compared to children maintaining a non-excess weight (based on body mass index) during follow-up incident and persistent cases of excess weight (overweight or obesity) had an odds ratio (OR) for high blood pressure of 2.49 (95% confidence interval (CI) 1.50–4.13) and OR 2.54 (95% CI 1.27–5.07), respectively. Regarding abdominal obesity we estimated OR 2.81 (95% CI 0.98–8.02) for incident cases and OR 3.42 (95% CI 1.38–8.49) for persistent cases. Similar estimates for the waist–height ratio were observed. Individuals who experienced remission to non-excess weight did not have an increased risk of high blood pressure. Conclusions We observed an increased risk for high blood pressure among 4-year-olds who presented with persistent or incident cases of excess weight (body mass index) or abdominal obesity after 2 years of follow-up. Children with excess weight or obesity at baseline who remitted to non-excess weight did not exhibit an increased risk of high blood pressure.

P4346Religious education and midlife observance are associated with lower coronary heart disease (CHD) mortality 23 years later

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Eilat-Adar ◽  
U Goldbourt
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Socioeconomic Status ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
Reference Group ◽  
Middle Aged

Abstract Objective To determine whether self-reported religiosity is associated with decreased coronary mortality risk in middle-aged men when rates are adjusted for known confounders. Design The Israeli Ischemic Heart Disease (IIHD) Project (n=10,232) was chosen by stratified sampling of civil servants and municipal male employees, men aged 40–65 in 1963. Subjects were seen upon enrollment (1963) and at two follow-up visits (1965 and 1968). Extent of religiosity according to belief and practice collected in 1965 on a scale from 1 to 5. Religiosity was defined as follow: (1) The most-strict observance of religious rules “Haredim”. (2) “Religious” (3) “Traditional” (4) “Secular” (5) The part of the latter who declared themselves to be “nonbelievers” were categorized as “agnostic”. Main outcome measure Coronary heart disease (CHD) death, determined from death certificates in 23 years of follow-up Results Among 9245 participants, 1098 died from CHD during 23 years follow up. Ever smoking, Body mass index (BMI) and socioeconomic status were significantly lower while age and diabetes were higher according to increasing religiosity. Religiosity was inversely related to CHD mortality. Demographic, anthropometric characteristics according to religion, and odds ratio (OR), 95% confidence interval (95% CI), for CHD mortality, (using agnostic as a reference group) are presented in table 1. Characteristics according to religion Religiosity Haredim (n=2103) Religious (n=1528) Traditional (n=1782) Secular (n=2085) Agnostic (n=1747) P for trend Age years (SD) 50.2 (6.9) 48.8 (6.6) 48.4 (6.7) 48.8 (6.6) 45.9 (6.8) <0.001 Ever smoking% 58.7 67.6 70.7 71.9 72.6 0.001 Systolic blood pressure (mmHg) 136 (21) 135 (20) 135 (21) 134 (20) 135 (20) 0.115 Diabetes (%) 9.8 11.1 8.3 8.8 6.5 <0.001 Socioeconomic status 2.2 (1.3) 2.3 (1.1) 2.7 (1.1) 2.7 (1.2) 3.1 (1.4) <0.001 BMI kg/m2 (SD) 22.5 (3.6) 25.9 (3.5) 25.9 (3.2) 25.6 (3.2) 25.4 (2.9) 0.028 Cholesterol (mg%) 201 (38) 207 (41) 208 (39) 214 (40) 218 (40) 0.001 Number of death (% category) 187 (8.9) 161 (10.5) 185 (10.4) 228 (10.9) 225 (12.9) <0.001 OR (95% CI)* 0.67 (0.53–0.85) 0.85 (0.67–1.08) 0.84 (0.67–1.05) 0.87 (0.71–1.08) 1 *Adjusted for age, cigarette smoking, systolic blood pressure, diabetes, socioeconomic status, body mass index and cholesterol. Conclusion Religiosity was associated with lower CHD death in employed middle aged Israeli men followed up prospectively for 23 years.

scholarly journals Body mass index (BMI) and quality of life among long-term survivors of childhood acute lymphoblastic leukemia

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 178
Author(s):  
Srilakshmi P. Vankina ◽  
Rachel I. Vogel ◽  
Patricia I. Jewett ◽  
Alexander A. Boucher ◽  
Sanyukta K. Janardan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Mass Index ◽  
Acute Lymphoblastic Leukemia ◽  
Body Mass ◽  
Lymphoblastic Leukemia ◽  
Healthy Weight ◽  
Childhood All ◽  
Long Term Survivors

Background: Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) are at risk of overweight and related chronic morbidities. As childhood cancer survival has been improving, long-term quality of life (QOL) among cancer survivors becomes more important. We examined the association of body mass index with physical and psychosocial QOL among childhood ALL survivors who returned for long-term follow-up after end of therapy. Methods: Using a cross-sectional survey (2006-2012), we assessed the association between body mass index and quality of life in 58 long-term survivors of childhood ALL (ages 9 to 43 at the time of survey/measurement) using age-appropriate QOL instruments (Health-Related Quality of Life Short Form – SF-36 or Child Health Questionnaire-PF-50). Results: Half of the participants were overweight or obese at the time of survey. Mean QOL scores were similar to population norms. Compared to underweight/healthy weight status, being overweight/obese was not significantly associated with poorer physical QOL, but with poorer psychosocial QOL (47.1±13.2 vs. 54.0±6.0, P=0.01, effect size Cohen’s d=0.67), which remained statistically significant after adjusting for age and sex. Conclusions: Weight management should be the target of timely interventions among survivors of childhood ALL.

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