Clinical Value of Iodine-123-Alpha-Methyl-L-Tyrosine Single-Photon Emission Tomography in the Differential Diagnosis of Recurrent Brain Tumor in Patients Pretreated for Glioma at Follow-Up

2002 ◽  
Vol 20 (2) ◽  
pp. 396-404 ◽  
Author(s):  
S. Samnick
Keyword(s):  
Differential Diagnosis ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Single Photon Emission ◽  
Clinical Value ◽  
Recurrent Brain Tumor ◽  
Iodine 123 ◽  
Photon Emission Tomography

Clinical Value of Iodine-123-Alpha-Methyl-l-Tyrosine Single-Photon Emission Tomography in the Differential Diagnosis of Recurrent Brain Tumor in Patients Pretreated for Glioma at Follow-Up

2002 ◽  
Vol 20 (2) ◽  
pp. 396-404 ◽  
Author(s):  
Samuel Samnick ◽  
Jochen B. Bader ◽  
Dirk Hellwig ◽  
Jean Richard Moringlane ◽  
Christof Alexander ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Single Photon ◽  
Photon Emission ◽  
Tumor Grade ◽  
Single Photon Emission Tomography ◽  
Emission Tomography ◽  
Single Photon Emission ◽  
Iodine 123 ◽  
Photon Emission Tomography

PURPOSE: To assess the clinical potential of iodine-123-alpha-methyl-l-tyrosine (IMT) and single-photon emission tomography (SPET) in the differential diagnosis of recurrences in patients pretreated for gliomas at follow-up. PATIENTS AND METHODS: Seventy-eight patients were examined after primary therapy over 36 months. Histopathologic diagnoses of all patients was known at first treatment; magnetic resonance and/or computed tomography examination was performed in addition to IMT-SPET. Cerebral SPET images were acquired 20 minutes after intravenous application of 190 ± 10 MBq of IMT. SPET images were classified as positive or negative for recurrent tumor visually and by calculating the ratios between tracer accumulation in the lesion and the unaffected contralateral regions of reference using region of interest. Final diagnoses were based on prospective clinicopathologic findings obtained independently of IMT-SPET. RESULTS: IMT-SPET detected all high-grade recurrent gliomas (grade 4; sensitivity, 100%). A difference could be demonstrated in grade 2 and 3 recurrences (sensitivity, 84% and 92%, respectively). Moreover, benign posttherapeutic lesions (postoperative scars, radiation necrosis) were correctly diagnosed as negative for tumor recurrence. In general, IMT uptake in grade 2 (1.45 ± 0.24) was significantly lower than that in grades 3 (1.70 ± 0.41) and 4 (1.88 ± 0.32). However, it was difficult to evaluate tumor grade only from the IMT accumulation in individual cases. CONCLUSION: IMT-SPET seems highly useful for detecting and delineating recurrent gliomas and differentiating between benign posttherapeutic lesions and malignant tumor tissue. It may be a valuable clinical tool to diagnose recurrences in patients pretreated for gliomas at follow-up. However, it showed limitations in determining histologic tumor grade.

Thallium-201 single-photon emission tomography in the treatment follow-up of nasopharyngeal carcinoma

1997 ◽  
Vol 24 (3) ◽  
pp. 305-311 ◽  
Author(s):  
Takashi Togawa ◽  
Nobuharu Yui ◽  
Fujimi Kinoshita ◽  
Masamichi Yanagisawa ◽  
Kazuo Hatano ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Single Photon ◽  
Photon Emission ◽  
Thallium 201 ◽  
Single Photon Emission Tomography ◽  
Emission Tomography ◽  
Single Photon Emission ◽  
Photon Emission Tomography
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