scholarly journals Fluorouracil Bolus Use in Infusional Regimens Among Oncologists—A Survey by Brazilian Group of Gastrointestinal Tumors

2021 ◽  
pp. 1270-1275
Author(s):  
Renata D. Peixoto ◽  
Anelisa K. Coutinho ◽  
Rui Fernando Weschenfelder ◽  
Gabriel Prolla ◽  
Duilio Rocha ◽  
...  
Keyword(s):  
Demographic Data ◽  
Dihydropyrimidine Dehydrogenase ◽  
Early Career ◽  
Prescribing Patterns ◽  
Multiple Choice Questions ◽  
Cross Sectional ◽  
Gastrointestinal Malignancies ◽  
Exact Test ◽  
Metastatic Setting ◽  
Oncology Practice

PURPOSE The utility of administering fluorouracil (5-FU) in bolus in regimens of infusional 5-FU has been questioned. We aimed to quantify the use of 5-FU bolus in infusional regimens for gastrointestinal malignancies among Brazilian oncologists. METHODS This was a cross-sectional electronic survey composed of eight multiple-choice questions sent to Brazilian oncologists during 14 days in February 2021. The survey instrument collected demographic data of participants and assessed practices in terms of 5-FU bolus use. We evaluated the association of demographic variables and 5-FU prescribing patterns with Fisher’s exact test (odds ratio [OR]). RESULTS The survey was completed by 332 medical oncologists. Overall, 37% were experienced oncologists and 32% were gastrointestinal specialists. In the first-line metastatic and in the adjuvant settings, 40% and 67% of oncologists always prescribe 5-FU bolus in infusional regimens, respectively. Experienced oncologists more frequently omit 5-FU bolus when compared with early-career oncologists, both in the metastatic (41% v 26%; OR, 1.98; P = .005) and adjuvant settings (28% v 14%; OR, 2.32; P = .003). In addition, more GI specialists remove 5-FU bolus when compared with generalists, but only in the metastatic setting (44% v 25%; OR, 2.33; P = .001). GI specialists are more likely to consider that treatment efficacy is not affected by 5-FU bolus withdrawal than are generalists (89% v 75%; OR, 2.65; P = .003). Most respondents (67%) keep leucovorin at the same doses when omitting 5-FU bolus, and only 16% always recommend dihydropyrimidine dehydrogenase testing. CONCLUSION Our survey indicates that experience in oncology practice and percentage of time dedicated to treat GI cancers influence the prescription of 5-FU bolus in Brazil, with more frequent omission of it among experienced gastrointestinal specialists, particularly in the metastatic setting.

Germline pharmacogenomics of thymidylate synthase gene in patients with gastrointestinal malignancies treated with fluoropyrimidines-based chemotherapy regimens.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 545-545 ◽  
Author(s):  
Saad Awan ◽  
Girijesh K. Patel ◽  
Anu Singh Maharjan ◽  
Gwendolyn A. McMillin ◽  
William R. Taylor ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Promoter Region ◽  
Active Metabolite ◽  
Dihydropyrimidine Dehydrogenase ◽  
S Phase ◽  
Gastrointestinal Malignancies ◽  
Exact Test ◽  
Racial Background ◽  
Dehydrogenase Gene ◽  
Grade 3

545 Background: Fluoropyrimidines are antimetabolites that target the S phase of the cell cycle. The active metabolite, 5-fluorodeoxyuridine monophosphate inhibits thymidylate synthase (TS) enzyme, thus preventing DNA synthesis and ultimately cell death. While controversy exists in the literature, polymorphism in the promoter region of thymidylate synthase gene (TYMS) that decrease TS expression has been associated with increased fluoropyrimidines-associated toxicities. This study explored the association between polymorphism in the promoter region of TYMS gene and fluoropyrimidines-associated toxicities in patients with gastrointestinal malignancies with mixed racial background. Methods: Between 2011 and 2018, 126 patients were genotyped for TYMS. Patients with known high-risk dihydropyrimidine dehydrogenase gene variants were excluded. Fluoropyrimidines-associated toxicity was graded according to the National Cancer Institiute Common Terminology Criteria for Adverse Events (v 5.0). Fisher’s exact test was used for statistical analysis. Results: TYMS genotypes that predict increased TS expression (3RG/3RG, 3RG/3RC, 2R/3RG, 2R/4R, 3R/4R, 4R/3RG) were identified in 55 patients (44%). TYMS genotypes that predict decreased TS expression (2R/2R, 2R/3RC, 3RC/3RC) were seen in 71 patients (56%). Among patients with genotypes that predict increased TS expression (N = 55), 12 patients had grade 3-4 toxicity (22%) while among patients with genotypes that predict decreased TS expression, 30 patients had grade 3-4 toxicities (42%) (P = 0.0219). Compared to patients with genotypes predicting increased TS expression, 17 out of 31 patients (55%) with 2R/2R TYMS genotype had grade 3-4 toxicity (P = 0.0039) and 15 out 40 patients (38%) with 2R/3RC and 3RC/3RC TYMS genotype had grade 3-4 toxicity (P = 0.1108). Among patients with 2R/2R TYMS, Caucasians represented 61% and African Americans represented 39%. Females represented 65% of the patients. Conclusions: Polymorphism in the promoter region of TYMS gene that predict decreased TS expression due to 2R/2R variant was associated with grade 3-4 fluoropyrimidines-associated toxicities.

scholarly journals Healthcare Workers’ Attitudes toward Patients with COVID-19

2021 ◽  
Author(s):  
Joseph Ottolenghi ◽  
Rodney A McLaren ◽  
Cecilia Bahamon ◽  
Mudar Dalloul ◽  
Sandra McCalla ◽  
...  
Keyword(s):  
New York ◽  
Registered Nurses ◽  
Healthcare Workers ◽  
Survey Study ◽  
Protective Equipment ◽  
Risk Of Infection ◽  
Demographic Information ◽  
Multiple Choice Questions ◽  
Cross Sectional ◽  
Exact Test

Abstract Background Early in the SARS-CoV-2 pandemic, before the routine availability and/or use of personal protective equipment, healthcare workers were understandably concerned. Our aim was to explore healthcare workers’ attitudes towards patients infected with SARS-CoV-2 at the time of the nation’s first surge in two highly affected hospitals in New York. Methods We performed a cross-sectional, self-administered survey study of healthcare workers. The survey consisted of 17 multiple-choice questions including demographic information, ethics and willingness to care for patients with SARS-CoV-2 infection. Subgroup analyses were performed using Fisher’s exact test. Results Of 340 healthcare workers approached, 338 (99.4%) consented to the survey; 163 (48.7%) were registered nurses and 160 (48.3%) lived with children. While 326 (97.3%) workers were concerned about putting their family/coworkers at risk of infection after caring for a patient with SARS-CoV-2, only 30 (8.9%) were unwilling to treat a patient with SARS-CoV-2 infection. Registered nurses were more likely than other healthcare workers to think it was ethical to refuse care for SARS-CoV-2 infected patients, worried more often about contracting infection, and felt that SARS-CoV-2 added to their stress level (p=.009, p=.018, p<.001, respectively). A similar contrast was seen when comparing workers who live with children with those that did not. Conclusion Levels of stress and concern were extremely high. In spite of that, the overwhelming majority of workers were willing to treat patients with SARS-CoV-2 infection. Registered nurses and healthcare workers who live with children were more likely to think it is ethical to refuse care for SARS-CoV-2 infected patients.

scholarly journals 3377 A cross-sectional analysis of opioid prescribing patterns among gynecologic oncologists using Medicare fee-for service provider utilization & payment data

2019 ◽  
Vol 3 (s1) ◽  
pp. 31-31
Author(s):  
David Samuel ◽  
Devin Miller ◽  
Sara Isani ◽  
Dennis Kuo ◽  
Gregory Gressel
Keyword(s):  
National Level ◽  
Adverse Outcomes ◽  
Prescribing Patterns ◽  
Fee For Service ◽  
Years Of Experience ◽  
Cross Sectional ◽  
Opioid Prescription ◽  
Exact Test ◽  
Opioid Prescribing ◽  
National Medical

OBJECTIVES/SPECIFIC AIMS: Opioids are the first-line treatment for moderate to severe cancer-related pain. Increased awareness of opioid prescription misuse and adverse outcomes has prompted statements on their use from multiple national medical groups. In this study we characterize national-level opioid prescription patterns among gynecologic oncologists treating Medicare beneficiaries. METHODS/STUDY POPULATION: The Centers for Medicare and Medicaid Services (CMS) database was used to access Medicare Part D beneficiary data (2016). All available opioid claims prescribed by gynecologic oncologists were identified. Medication type, prescription length and other prescribing factors were recorded. Physician demographics were obtained from departmental websites and accrediting bodies. Physicians with <10 opioid claims are not included in the CMS database. Bivariate statistical analysis including chi-squared, Fisher’s exact test and Wilcoxon rank-sum test were performed to compare variables with threshold for significance set at p<0.05. Linear regression modeling was also performed to examine association of gender with number of opioids prescribed. RESULTS/ANTICIPATED RESULTS: A total of 494 board-certified gynecologic oncologists were included in this analysis. In 2016, gynecologic oncologists wrote 23,584 opioid prescriptions for 267,824 days of treatment (average of 9.24 prescribed days per claim). The most commonly prescribed opioid was oxycodone/acetaminophen (41%). Male physicians had significantly more opioid prescription claims than females (p<0.01) including after adjusting for differences in years of experience. The majority of physicians had 11-50 opioid prescription claims (68%). A minority were high prescribing physicians with >100 opioid claims (11%). Of these, the overwhelming majority were male (82%) and late career (46%, >15 years since board certification). Physicians in the South had the greatest number of opioid prescription claims and significantly more than physicians in the Northeast, who had the fewest (p<0.01). Mean number of opioid claims increased with increasing years of experience (p<0.05). DISCUSSION/SIGNIFICANCE OF IMPACT: Among gynecologic oncologists, there were gender-based, regional and experience-related variations in opioid prescribing in the Medicare population in 2016. Further longitudinal studies are required to elucidate secular trends in opioid prescription practice.

The Correlation Between DPYD*9A(c.85T>C) Genotype and Dihydropyrimidine Dehydrogenase Deficiency Phenotype in Patients With Gastrointestinal Malignancies Treated With Fluoropyrimidines

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S29-S30
Author(s):  
Anu S Maharjan ◽  
Gwendolyn McMillin ◽  
Moh’d Khushman ◽  
Girijesh Patel
Keyword(s):  
Small Sample Size ◽  
Dihydropyrimidine Dehydrogenase ◽  
Small Sample ◽  
Phenotype Correlation ◽  
Gastrointestinal Malignancies ◽  
Exact Test ◽  
Genotype Phenotype Correlation ◽  
Gi Cancer ◽  
Racial Background ◽  
Grade 3

Abstract Introduction The correlation between DPYD*9A (c.85T>C) genotype and dihydropyrimidine dehydrogenase (DPD) deficiency phenotype is controversial. In a cohort of 28 patients, DPYD*9A was the most commonly diagnosed variant (46%) and there was a noticeable genotype-phenotype correlation. Here we genotyped a larger cohort of a mixed racial background to explore the incidence of DPYD*9A variant and to further study the genotype-phenotype correlation. Methods Genotyping for high-risk DPYD variants (DPYD*2A, DPYD*13, and DPYD*9B) and the DPYD*9A variant was performed on 113 patients with gastrointestinal malignancies (GI) treated with fluoropyrimidines, using TaqMan chemistry. The prevalence of different DPYD variants was further analyzed in 1,283 retrospective data from ARUP laboratories. Fluoropyrimidines-associated toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (v 5.0). Fisher’s exact test was used for statistical analysis. Results In total, 1,283 were retrospectively reviewed for DPYD variants. Four patients (0.31%) carried DPYD c.-1590T>C, 10 patients (0.55%) carried DPYD c.1679T>G (*13), 36 patients (2.8%) carried DPYD c.2846A>T, and 527 patients (41.1%) carried DPYD c.85T>C (*9A). In the GI cancer cohort, DPYD variants were identified in 61 patients (54%), showing similar prevalence as the retrospective analysis. Caucasians represented 54% and African Americans represented 43%. Twenty-eight patients (46%) were females. Heterozygous DPYD*9A was identified in 46 patients (41%) and homozygous DPYD*9A was identified in 11 patients (10%). DPYD*2A was identified in 3 patients and DPYD*9B was identified in 2 patients (one patient had double heterozygous *9A and *9B). Grade 3 to 4 toxicities were experienced in 26 patients with mutant DPYD*9A (3 patients had homozygous DPYD*9A) and in 20 patients with no identified DPYD mutation (P = .7035). In patients who received full-dose fluoropyrimidines (N = 85), grade 3 to 4 toxicities were experienced in 22 patients with mutant DPYD*9A (2 patients had homozygous DPYD*9A) and in 17 patients with no identified DPYD mutation (P = .8275). Conclusion In the GI cancer population, the DPYD*9A variant was identified in 54% of patients. The correlation between DPYD*9A variant and DPD clinical phenotype was not significant. The noticeable correlation that was previously reported is likely due to small sample size and selection bias.

scholarly journals The Prevalence of Burnout Among US Neurosurgery Residents

Neurosurgery ◽  
2017 ◽  
Vol 83 (3) ◽  
pp. 582-590 ◽  
Author(s):  
Hakeem J Shakir ◽  
Matthew J McPheeters ◽  
Hussain Shallwani ◽  
Joseph E Pittari ◽  
Renée M Reynolds
Keyword(s):  
Descriptive Analysis ◽  
Nonparametric Tests ◽  
Early Career ◽  
Personal Accomplishment ◽  
Lower Prevalence ◽  
Cross Sectional ◽  
Exact Test ◽  
Increased Risk ◽  
Significant Difference ◽  
Practicing Physicians

Abstract BACKGROUND Burnout is a syndrome of emotional exhaustion, depersonalization, and reduced personal accomplishment. Its prevalence among US physicians exceeds 50% and is higher among residents/fellows. This is important to the practice of neurosurgery, as burnout is associated with adverse physical health, increased risk of substance abuse, and increased medical errors. To date, no study has specifically addressed the prevalence of burnout among neurosurgery residents. OBJECTIVE To determine and compare the prevalence of burnout among US neurosurgery residents with published rates for residents/fellows and practicing physicians from other specialties. METHODS We surveyed 106 US neurosurgery residency training programs to perform a descriptive analysis of the prevalence of burnout among residents. Data on burnout among control groups were used to perform a cross-sectional analysis. Nonparametric tests assessed differences in burnout scores among neurosurgery residents, and the 2-tailed Fisher's exact test assessed burnout between neurosurgery residents and control populations. RESULTS Of approximately 1200 US neurosurgery residents, 255 (21.3%) responded. The prevalence of burnout was 36.5% (95% confidence interval: 30.6%-42.7%). There was no significant difference in median burnout scores between gender (P = .836), age (P = .183), or postgraduate year (P = .963) among neurosurgery residents. Neurosurgery residents had a significantly lower prevalence of burnout (36.5%) than other residents/fellows (60.0%; P &lt; .001), early career physicians (51.3%; P &lt; .001), and practicing physicians (53.5%; P &lt; .001). CONCLUSION Neurosurgery residents have a significantly lower prevalence of burnout than other residents/fellows and practicing physicians. The underlying causes for these findings were not assessed and are likely multifactorial. Future studies should address possible causes of these findings.

scholarly journals Antibiotics prescribing patterns in medical wards of Yangon General Hospital, Myanmar

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Aye Thi Khaing ◽  
Nang Hla Hla Win
Keyword(s):  
General Hospital ◽  
Demographic Data ◽  
Inappropriate Prescribing ◽  
Cross Sectional Study ◽  
Prescribing Patterns ◽  
Antibiotic Prescribing ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Medical Wards ◽  
Pro Forma

Introduction: Irrational and inappropriate prescribing of antimicrobial is common in hospitals and contributes to the development of antibiotic resistance in clinical practice. In Myanmar, there is insufficient information concerning antibiotics prescribing patterns in some hospitals. Therefore, the aim of this study was to determine the prescribing patterns of antibiotics in various infections. Methods: A descriptive cross-sectional study was carried out over a 3- month period in the medical wards of Yangon General Hospital. A total 1054 patients who were prescribed with antibiotics for post-admission day were selected. Relevant demographic data, discharge diagnosis, antibiotic prescribing patterns and outcomes of the patients were collected through pro-forma. Results: The result revealed that the antibiotics prescribing rate in Yangon General Hospital was 49%. Amongst the major indications included acute gastroenteritis (10%), chest infections (6.8%), skin and soft tissue infections (6.5%), pneumonia (6.1%) and spontaneous bacterial peritonitis (6.0%). The most frequently prescribed antibiotics were combination of aminopenicillin with beta lactamase inhibitors (29.4%), metronidazole (28.2%), ceftriaxone (24.4%), azithromycin (15.2%) and cefixime (12.8%). The majority of the patients were discharged from hospital (73.7%) whereas the expired population was 8.6%. Conclusions: This study offers useful information in developing antibiogram for medical wards of Yangon General Hospital, Myanmar. The findings of this study could contribute to improvement in the treatment outcomes.

scholarly journals The Norwegian public’s ability to assess treatment claims: results of a cross-sectional study of critical health literacy

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 179 ◽  
Author(s):  
Astrid Dahlgren ◽  
Kjetil Furuseth-Olsen ◽  
Christopher James Rose ◽  
Andrew David Oxman
Keyword(s):  
Health Literacy ◽  
Demographic Data ◽  
Educational Interventions ◽  
Cross Sectional Study ◽  
Self Report ◽  
Multiple Choice Questions ◽  
Cross Sectional ◽  
Critical Health Literacy ◽  
Key Concepts ◽  
Treatment Claims

Background: Few studies have evaluated the ability of the general public to assess the trustworthiness of claims about the effects of healthcare. For the most part, those studies have used self-reported measures of critical health literacy. Methods: We mailed 4500 invitations to Norwegian adults. Respondents were randomly assigned to one of four online tests that included multiple-choice questions that test understanding of Key Concepts people need to understand to assess healthcare claims. They also included questions about intended behaviours and self-efficacy. One of the four tests was identical to one previously used in two randomised trials of educational interventions in Uganda, facilitating comparisons to Ugandan children, parents, and teachers. We adjusted the results using demographic data to reflect the population. Results: A total of 771 people responded. We estimate that at least half of Norwegian adults understand 18 of the 30 Key Concepts (i.e. the adjusted proportion of correct answers was > 50%). On the other hand, less than half understood 13 of the concepts. The results for Norwegian adults were better than the results for Ugandan children in the intervention arm of the trial and parents, and similar to those of Ugandan teachers in the intervention arm of the trial. Based on self-report, most Norwegians are likely to find out the basis of treatment claims, but few consider it easy to assess whether claims are based on research and to assess the trustworthiness of research. Conclusions: Norwegian adults do not understand many concepts that are essential for assessing healthcare claims and making informed choices. This can result in poorly informed decisions, underuse of effective interventions, and overuse of ineffective or harmful interventions.

scholarly journals Job Satisfaction and Its Determinants among Nurse Anesthetists in Clinical Practice: The Botswana Experience

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Mamo Woldu Kassa ◽  
Alemayehu Ginbo Bedada
Keyword(s):  
Job Satisfaction ◽  
Clinical Practice ◽  
Short Form ◽  
Demographic Data ◽  
Well Being ◽  
Cross Sectional Study ◽  
Nurse Anesthetists ◽  
Categorical Variables ◽  
Cross Sectional ◽  
Exact Test

Job satisfaction (JS) correlates positively with patients’ satisfaction and outcomes and employees’ well-being. In Botswana, the level of job satisfaction and its determinants among nurse anesthetists were not investigated. A cross-sectional study was conducted from January 2020 to June 2020 encompassing all nurse anesthetists in clinical practice in Botswana. A self-administered questionnaire was used that incorporated demographic data, reasons to stay on or leave their job, and a validated 20-item short form of the Minnesota Satisfaction Questionnaire which was pretested on five of our nurse anesthetists. Percentage is used to describe the data. The independence of categorical variables was examined using chi-square or Fisher’s exact test. p value <0.05 was considered statistically significant. In Botswana, a total of 76 nurse anesthetists were in clinical practice during the study period. Sixty-six (86.9%) responded to the survey. Gender distribution was even, 50.0%. The overall JS was 36.4%. Males had significantly higher JS than females, p = 0.001 . Significantly higher job satisfaction was found in married nurse anesthetists ( p = 0.039 ), expatriate nurse anesthetists ( p = 0.001 ), nurse anesthetists in non-referral hospitals ( p = 0.023 ), and nurse anesthetists with ≥10 years’ experience ( p = 0.019 ). Nurse anesthetists were satisfied with security, social service, authority, ability utilization, and responsibility in ≥60.0% of the cases. They were not satisfied in compensation, working condition, and advancement in a similar percentage. The main reason to stay on their job was to serve the public in 68.2%. In Botswana, employers should make an effort to address the working conditions, compensation, and advancement of nurse anesthetists in clinical practice.

scholarly journals Breastfeeding Self-Efficacy for Mothers at the Bulili Health Center, City Palu, Indonesia

2022 ◽  
Vol 10 (E) ◽  
pp. 18-21
Author(s):  
Hemiyanty Hemiyanty ◽  
Bertin Ayu Wandira ◽  
Novi Inriyanny Suwendro
Keyword(s):  
Health Center ◽  
Self Efficacy ◽  
Short Form ◽  
Demographic Data ◽  
P Value ◽  
Verbal Persuasion ◽  
Cross Sectional ◽  
Exact Test ◽  
Self Confidence ◽  
Center City

Background: Breastfeeding plays an important role in building the relationship between mother and baby, also the baby's growth and development. Improving the mother's self-confidence during breastfeeding is a key to the success of breastfeeding. Exclusive breastfeeding in the working area of the Bulili Health Center is still low, about 37.17%. Breastfeeding self-efficacy (BSE) is a mother's self-confidence in her ability to breastfeed her baby. Objective: This study aimed to analyze the factors related to breastfeeding self-efficacy in the working area of the Bulili Public Health Center, Palu City. Method: This research design was quantitative with a cross-sectional design, involving 82 mothers who have babies aged 6-12 months in the working area of the Bulili Health Center. The instrument used in this study was a Breastfeeding Self-Efficacy Scale-Short Form questionnaire containing demographic data, breastfeeding experience data, observations of others, verbal persuasion, physical and emotional conditions. The data were analyzed using SPSS and Fisher's Exact Test with a significant level of p <0.05. Results: The sample with good breastfeeding experience was 62.9%, those who got the experience of others in the good category were 61.0%, those samples with verbal persuasion were in a good category of 75.6%. All samples (100%) were in good physiological and emotional condition. Breastfeeding Self-efficacy with a good category was 90.2%. The statistical test showed that the respondent's breastfeeding experience, other people's experiences, and verbal persuasion did not significantly correlate with Breastfeeding Self-efficacy with a p-value <0.05. Conclusion: Breastfeeding experience factors, experiences of other people, physiological and emotional conditions, and verbal persuasion did not significantly relate to the breastfeeding self-efficacy (BSE) of mothers and babies in the Bulili Health Center Work Area, Palu City.

scholarly journals Teaching remotely during the COVID-19 pandemic: perceptions from and psychological impact on health science professors in Brazil

2021 ◽  
Vol 10 (17) ◽  
pp. e151101724451
Author(s):  
Andrezza Lauria ◽  
Gabriela Mayrink ◽  
Fernanda Mayrink Gonçalves Liberato ◽  
Clarice Maia Soares de Alcântara Pinto ◽  
Patrick Filgueiras da Silva ◽  
...  
Keyword(s):  
Online Teaching ◽  
Demographic Data ◽  
Psychological Impact ◽  
Female Gender ◽  
Health Science ◽  
Multiple Choice Questions ◽  
Cross Sectional ◽  
University Professors ◽  
University Funding ◽  
Geopolitical Region

With the social distancing required by the coronavirus (COVID-19) pandemic, the creation of a new pedagogical model became a sudden challenge for educational institutions. This study sought to assess health science professors’ experiences and perceptions during the COVID-19 pandemic. An epidemiological, descriptive, cross-sectional, observational, and quantitative approach was applied and included the application of a structured and self-administered virtual questionnaire containing objective and multiple-choice questions on demographic data, online teaching activities, continuing education, learning environments, and difficulties faced. Seven questions from the Generalized Anxiety Disorder Screening Tool (GAD-7) were added to assess anxiety. One hundred and thirty-eight university professors in Brazil completed the questionnaire. Of these, 87 were employed by public institutions and 51 worked at private institutions. Geopolitical region in the country and university funding type were associated with universities’ ability or decision to offer courses online. Among the professors, being of female gender and a decrease in household income were the factors most closely associated with increased anxiety. Professors also reported difficulties in interacting with students online, the need to assume more childcare, and difficulty in concentrating at home to be the main barriers to successful online teaching.

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