scholarly journals Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study

2020 ◽  
pp. 532-541 ◽  
Author(s):  
Violet Kayamba ◽  
Kanekwa Zyambo ◽  
Chola Mulenga ◽  
Simutanyi Mwakamui ◽  
Mizinga Jacqueline Tembo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Gastric Cancer ◽  
Dna Damage ◽  
Smoke Exposure ◽  
Intestinal Type ◽  
Processed Meat ◽  
Daily Consumption ◽  
Biomass Smoke ◽  
Biomass Smoke Exposure

PURPOSE We investigated the association between gastric cancer and environmental and dietary exposures. In addition, we explored probable mechanistic pathways for the influence of biomass smoke on gastric carcinogenesis. PATIENTS AND METHODS The study was conducted in Lusaka, Zambia. Questionnaires were used to collect data on risk factors, whereas enzyme-linked immunosorbent assays and high-performance liquid chromatography were used to measure biologic exposures. Study data were analyzed using contingency tables and logistic regression. RESULTS We enrolled 72 patients with gastric adenocarcinoma and 244 controls. Gastric cancer was positively associated with rural residence (odds ratio [OR], 2.9; 95% CI, 1.5 to 5.3), poverty (OR, 4.2; 95% CI, 1.9 to 9.1), and daily consumption of processed meat (OR, 6.4; 95% CI, 1.3 to 32) and negatively associated with consumption of green vegetables (OR, 0.2; 95% CI, 0.1 to 0.5). Gastric cancer was also associated with biomass smoke exposure (OR, 3.5; 95% CI, 1.9 to 6.2; P < .0001), an association that was stronger for intestinal-type cancers (OR, 3.6; 95% CI, 1.5 to 9.1; P = .003). Exposure to biomass smoke in controls was associated with higher urinary levels of 8-isoprostane ( P < .0001), 8-hydroxydeoxyguanosine ( P = .029), and 1-hydroxypyrene ( P = .041). Gastric cancer was not associated with biochemical measures of current exposure to aflatoxins or ochratoxins. CONCLUSION In Zambia, exposure to biomass smoke, daily consumption of processed meat, and poverty are risk factors for gastric cancer, whereas daily consumption of green vegetables is protective against gastric cancer. Exposure to biomass smoke was associated with evidence of oxidative stress and DNA damage, suggesting mechanistic plausibility for the observed association, and the association was restricted to intestinal-type gastric cancer.

Biomass Smoke Exposure and Acute Lower Respiratory Infections Among Guatemalan Children

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S185 ◽  
Author(s):  
J McCracken ◽  
J Schwartz ◽  
M Mittleman ◽  
L Ryan ◽  
A Díaz Artiga ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Smoke Exposure ◽  
Biomass Smoke ◽  
Acute Lower Respiratory Infections ◽  
Biomass Smoke Exposure

scholarly journals S131 Human macrophage model of biomass smoke exposure shows impaired ingestion of Streptococcus pneumoniae

Thorax ◽  
2011 ◽  
Vol 66 (Suppl 4) ◽  
pp. A60-A60
Author(s):  
A. N. Aljurayyan ◽  
D. G. Fullerton ◽  
S. Barrett ◽  
S. B. Gordon
Keyword(s):  
Streptococcus Pneumoniae ◽  
Smoke Exposure ◽  
Human Macrophage ◽  
Biomass Smoke ◽  
Biomass Smoke Exposure

scholarly journals Prevalence of COPD and respiratory symptoms associated with biomass smoke exposure in a suburban area

2018 ◽  
Vol Volume 13 ◽  
pp. 1727-1734 ◽  
Author(s):  
Alejandra Ramírez-Venegas ◽  
Mónica Velázquez-Uncal ◽  
Rosaura Pérez-Hernández ◽  
Nicolás Eduardo Guzmán-Bouilloud ◽  
Ramcés Falfán-Valencia ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Smoke Exposure ◽  
Suburban Area ◽  
Biomass Smoke ◽  
Biomass Smoke Exposure

scholarly journals Epidemiologic link between tuberculosis and cigarette/biomass smoke exposure: Limitations despite the vast literature

Respirology ◽  
2015 ◽  
Vol 20 (4) ◽  
pp. 556-568 ◽  
Author(s):  
Raju Bishwakarma ◽  
William H. Kinney ◽  
Jennifer R. Honda ◽  
Jenny Mya ◽  
Matthew J. Strand ◽  
...  
Keyword(s):  
Smoke Exposure ◽  
Biomass Smoke ◽  
Vast Literature ◽  
Biomass Smoke Exposure

scholarly journals Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hilda Vargas-Robles ◽  
Amelia Rios ◽  
Monica Arellano-Mendoza ◽  
Bruno A. Escalante ◽  
Michael Schnoor
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
High Fat Diet ◽  
Serum Triglyceride ◽  
High Fat ◽  
Daily Consumption ◽  
Beneficial Effects ◽  
Diet Supplementation

Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.

scholarly journals Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation

2021 ◽  
Author(s):  
Juliane Wunder ◽  
Daniela Pemp ◽  
Alexander Cecil ◽  
Maryam Mahdiani ◽  
René Hauptstein ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Risk Factors ◽  
Dna Damage ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Linear Regression Models ◽  
Cancer Etiology ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

AbstractBreast cancer etiology is associated with both proliferation and DNA damage induced by estrogens. Breast cancer risk factors (BCRF) such as body mass index (BMI), smoking, and intake of estrogen-active drugs were recently shown to influence intratissue estrogen levels. Thus, the aim of the present study was to investigate the influence of BCRF on estrogen-induced proliferation and DNA damage in 41 well-characterized breast glandular tissues derived from women without breast cancer. Influence of intramammary estrogen levels and BCRF on estrogen receptor (ESR) activation, ESR-related proliferation (indicated by levels of marker transcripts), oxidative stress (indicated by levels of GCLC transcript and oxidative derivatives of cholesterol), and levels of transcripts encoding enzymes involved in estrogen biotransformation was identified by multiple linear regression models. Metabolic fluxes to adducts of estrogens with DNA (E-DNA) were assessed by a metabolic network model (MNM) which was validated by comparison of calculated fluxes with data on methoxylated and glucuronidated estrogens determined by GC– and UHPLC–MS/MS. Intratissue estrogen levels significantly influenced ESR activation and fluxes to E-DNA within the MNM. Likewise, all BCRF directly and/or indirectly influenced ESR activation, proliferation, and key flux constraints influencing E-DNA (i.e., levels of estrogens, CYP1B1, SULT1A1, SULT1A2, and GSTP1). However, no unambiguous total effect of BCRF on proliferation became apparent. Furthermore, BMI was the only BCRF to indeed influence fluxes to E-DNA (via congruent adverse influence on levels of estrogens, CYP1B1 and SULT1A2).

Biomass smoke exposure and respiratory health in Madagascar

2018 ◽  
Author(s):  
Rondro Nirina Raharimanana ◽  
Andrianandrasana Herizo Rajaonary ◽  
Daniella Randriamanana ◽  
Jocelyn Rakotomizao ◽  
Joelson Rakotoson ◽  
...  
Keyword(s):  
Respiratory Health ◽  
Smoke Exposure ◽  
Biomass Smoke ◽  
Biomass Smoke Exposure
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