scholarly journals Prospects and Challenges for Clinical Decision Support in the Era of Big Data

2018 ◽  
pp. 1-12 ◽  
Author(s):  
Issam El Naqa ◽  
Michael R. Kosorok ◽  
Judy Jin ◽  
Michelle Mierzwa ◽  
Randall K. Ten Haken
Keyword(s):  
Machine Learning ◽  
Big Data ◽  
Decision Support ◽  
Clinical Decision Support ◽  
Learning Algorithms ◽  
Clinical Decision ◽  
Machine Learning Algorithms ◽  
Current Status ◽  
Analytical Approaches

Recently, there has been burgeoning interest in developing more effective and robust clinical decision support systems (CDSSs) for oncology. This has been primarily driven by the demands for more personalized and precise medical practice in oncology in the era of so-called big data (BD), an era that promises to harness the power of large-scale data flow to revolutionize cancer treatment. This interest in BD analytics has created new opportunities as well as new unmet challenges. These include: routine aggregation and standardization of clinical data, patient privacy, transformation of current analytical approaches to handle such noisy and heterogeneous data, and expanded use of advanced statistical learning methods on the basis of confluence of modern statistical methods and machine learning algorithms. In this review, we present the current status of CDSSs in oncology, the prospects and current challenges of BD analytics, and the promising role of integrated modern statistics and machine learning algorithms in predicting complex clinical end points, individualizing treatment rules, and optimizing dynamic personalized treatment regimens. We discuss issues pertaining to these topics and present application examples from an aggregate of experiences. We also discuss the role of human factors in improving the use and acceptance of such enhanced CDSSs and how to mitigate possible sources of human error to achieve optimal performance and wider acceptance.

scholarly journals Improving Heart Disease Prediction Using Random Forest and AdaBoost Algorithms

2021 ◽  
Vol 17 (11) ◽  
pp. 60
Author(s):  
Halima EL Hamdaoui ◽  
Said Boujraf ◽  
Nour El Houda Chaoui ◽  
Badr Alami ◽  
Mustapha Maaroufi
Keyword(s):  
Machine Learning ◽  
Heart Disease ◽  
Decision Support ◽  
Random Forest ◽  
Clinical Decision Support ◽  
Clinical Decision ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Random Forest Algorithm ◽  
Adaboost Algorithm

heart disease is a major cause of death worldwide. Thus, diagnosis and prediction of heart disease remain mandatory. Clinical decision support systems based on machine learning techniques have become the primary tool to assist clinicians and contribute to automated diagnosis. This paper aims to predict heart disease using Random Forest algorithm enhanced with the boosting algorithm Adaboost. The model is trained and tested on University of California Irvine (UCI) Cleveland and Statlog heart disease datasets using the most relevant features 14 attributes. The result shows that Random Forest algorithm combined with AdaBoost algorithm achieved higher accuracy than applying only Radom Forest algorithm, 96.16%, 95.98%, respectively. We compare our suggested model to report machine learning classifiers. Indeed, the obtained result is supporting the efficiency and validity of our model. Besides, the proposed model achieved high accuracy compared to existing studies in the literature that confirmed that a clinical decision support system could be used to predict heart disease based on machine learning algorithms.

scholarly journals An Intelligent System for Prediction of Severity of SARS-Cov-2 Infection and Progression to Critical Illness: Using Machine Learning Models

2021 ◽  
Author(s):  
mohammad reza afrash ◽  
Maryam Yaghoubi ◽  
Fatemeh Rahimi ◽  
Mostafa Shanbehzadeh ◽  
Mohammadkarim Bahadori
Keyword(s):  
Machine Learning ◽  
Decision Support ◽  
Critical Illness ◽  
Decision Support System ◽  
Clinical Decision Support ◽  
Support System ◽  
Clinical Decision Support System ◽  
Clinical Decision ◽  
Machine Learning Algorithms ◽  
Input Variables

Abstract Introduction: The rapid worldwide outbreak of coronavirus disease 2019 (COVID-19) has posed serious and extraordinary challenges to healthcare industries in predicting disease behavior, and outcomes. Aim: This study aimed to develop a Clinical Decision Support System (CDSS) for predicting the severity of SARS-CoV-2 infection and progression to critical illness in a patient with COVID-19 using several machine learning algorithms. Material and Methods: Using a two-center registry, the data of 2482 COVID-19 patients from February 9, 2020, to December 20, 2020, were reviewed. The Relief Feature Selection (RFS) algorithm was used for optimizing the input variables. Then, selected variables feed into ML models including XGBoost, HistGradient Boosting (HGB), Random Forest (RF), and Naïve Bayesian (NB) to construct prediction models. Afterwards, the performance of each combination was compared using some evaluation metrics. Eventually using the best ML model performance, a Clinical Decision Support System (CDSS) was implemented with C# programming language.Results: of the 63 included variables, 15 features were identified as the most important predictors. The experimental results indicated that the HGB classifier with an average classification accuracy of 94.2%, mean specificity of 92.4%, mean sensitivity of 91%, mean F-score of 87.2 %, and finally mean AUC of 87.3 % was selected as the most appropriate machine learning model for predicting the Severity of SARS-CoV-2.Conclusion: The results of this study showed that the hybrid ML algorithms and in particular the RFS-HGB (by optimizing input variables and customizing the structure of the algorithms (can help the frontline clinicians to predict the severity of COVID-19 progression.

Role of machine learning algorithms over heart diseases prediction

2020 ◽  
Author(s):  
Siva Kumar Jonnavithula ◽  
Abhilash Kumar Jha ◽  
Modepalli Kavitha ◽  
Singaraju Srinivasulu
Keyword(s):  
Machine Learning ◽  
Heart Diseases ◽  
Learning Algorithms ◽  
Machine Learning Algorithms

scholarly journals NCOG-31. DEVELOPMENT AND EVALUATION OF PROGNOSTIC MODELS TO PREDICT SURVIVAL OF PATIENTS WITH GLIOBLASTOMA MULTIFORME

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii135-ii136
Author(s):  
John Lin ◽  
Michelle Mai ◽  
Saba Paracha
Keyword(s):  
Machine Learning ◽  
Decision Support ◽  
Glioblastoma Multiforme ◽  
Random Forest ◽  
Regression Model ◽  
Clinical Decision Support ◽  
Multivariate Regression ◽  
Visual Analysis ◽  
Clinical Decision ◽  
Prognostic Models

Abstract Glioblastoma multiforme (GBM), the most common form of glioma, is a malignant tumor with a high risk of mortality. By providing accurate survival estimates, prognostic models have been identified as promising tools in clinical decision support. In this study, we produced and validated two machine learning-based models to predict survival time for GBM patients. Publicly available clinical and genomic data from The Cancer Genome Atlas (TCGA) and Broad Institute GDAC Firehouse were obtained through cBioPortal. Random forest and multivariate regression models were created to predict survival. Predictive accuracy was assessed and compared through mean absolute error (MAE) and root mean square error (RMSE) calculations. 619 GBM patients were included in the dataset. There were 381 (62.9%) cases of recurrence/progression and 53 (8.7%) cases of disease-free survival. The MAE and RMSE values were 0.553 and 0.887 years respectively for the random forest regression model, and they were 1.756 and 2.451 years respectively for the multivariate regression model. Both models accurately predicted overall survival. Comparison of models through MAE, RMSE, and visual analysis produced higher accuracy values for random forest than multivariate linear regression. Further investigation on feature selection and model optimization may improve predictive power. These findings suggest that using machine learning in GBM prognostic modeling will improve clinical decision support. *Co-first authors.

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