The Conundrum of Clinical Trial Endpoints in Multiple Myeloma: We Don’t Have All the Time in the World

2020 ◽  
Keyword(s):  
Clinical Trial ◽  
Multiple Myeloma ◽  
Clinical Trial Endpoints ◽  
The World ◽  
Trial Endpoints

scholarly journals Approach to the treatment of multiple myeloma: a clash of philosophies

Blood ◽  
2011 ◽  
Vol 118 (12) ◽  
pp. 3205-3211 ◽  
Author(s):  
S. Vincent Rajkumar ◽  
Gösta Gahrton ◽  
P. Leif Bergsagel
Keyword(s):  
Clinical Trial ◽  
Multiple Myeloma ◽  
Clinical Practice ◽  
Risk Stratification ◽  
Trial Design ◽  
Diagnosis And Treatment ◽  
Clinical Trial Endpoints ◽  
Trial Endpoints ◽  
Definition Of ◽  
Current Clinical Trial

Abstract In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity of current clinical trial endpoints, we highlight the major areas of debate and provide alternative viewpoints that have implications for trial design and interpretation, as well as clinical practice.

Novel mechanisms and clinical trial endpoints in intestinal fibrosis*

2021 ◽  
Author(s):  
Jie Wang ◽  
Sinan Lin ◽  
Jonathan Mark Brown ◽  
David van Wagoner ◽  
Claudio Fiocchi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intestinal Fibrosis ◽  
Clinical Trial Endpoints ◽  
Trial Endpoints

scholarly journals The Natural History of Untreated HIV Infection in Lima, Peru: Implications for Clinical Trial Endpoints for CTL Based HIV Vaccines

2005 ◽  
Vol 1 (4) ◽  
pp. 160-164 ◽  
Author(s):  
Daniel Corey ◽  
Hyung Woo Kim ◽  
Raul Salazar ◽  
Luis M. Gutierrez ◽  
Jorge Sánchez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Natural History ◽  
Hiv Infection ◽  
Hiv Vaccines ◽  
Clinical Trial Endpoints ◽  
History Of ◽  
Trial Endpoints

scholarly journals Ovarian cancer clinical trial endpoints: Society of Gynecologic Oncology white paper

2014 ◽  
Vol 132 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Thomas J. Herzog ◽  
Deborah K. Armstrong ◽  
Mark F. Brady ◽  
Robert L. Coleman ◽  
Mark H. Einstein ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Trial ◽  
Gynecologic Oncology ◽  
White Paper ◽  
Cancer Clinical Trial ◽  
Clinical Trial Endpoints ◽  
Trial Endpoints

scholarly journals Creatinine Fluctuation in Patients With Lupus Nephritis: Considerations for Clinical Trial Endpoints

2020 ◽  
Vol 5 (8) ◽  
pp. 1302-1305
Author(s):  
Salem Almaani ◽  
Udayan Bhatt ◽  
Cristina Arriens ◽  
Eloisa Bonfa ◽  
Maria Dall’Era ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lupus Nephritis ◽  
Clinical Trial Endpoints ◽  
Trial Endpoints

scholarly journals FDA ovarian cancer clinical trial endpoints workshop: A Society of Gynecologic Oncology White Paper

2017 ◽  
Vol 147 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Thomas J. Herzog ◽  
Gwynn Ison ◽  
Ronald D. Alvarez ◽  
Sanjeeve Balasubramaniam ◽  
Deborah K. Armstrong ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Trial ◽  
Gynecologic Oncology ◽  
White Paper ◽  
Cancer Clinical Trial ◽  
Clinical Trial Endpoints ◽  
Trial Endpoints

scholarly journals Multicenter Evaluation of Infant Lung Function Tests as Cystic Fibrosis Clinical Trial Endpoints

2010 ◽  
Vol 182 (11) ◽  
pp. 1387-1397 ◽  
Author(s):  
Stephanie D. Davis ◽  
Margaret Rosenfeld ◽  
Gwendolyn S. Kerby ◽  
Lyndia Brumback ◽  
Margaret H. Kloster ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Lung Function Tests ◽  
Clinical Trial Endpoints ◽  
Function Tests ◽  
Trial Endpoints
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