IL-6 and C-Reactive Protein as Potential Biomarkers for Checkpoint Inhibition

2019 ◽  
Keyword(s):  
Checkpoint Inhibition ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Biomarkers

scholarly journals Elevated procalcitonin and C-reactive protein as potential biomarkers of sepsis in a subpopulation of thrombotic microangiopathy patients

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Yasuko O. Erickson ◽  
Noelle I. Samia ◽  
Bruce Bedell ◽  
Kenneth D. Friedman ◽  
Bonnie S. Atkinson ◽  
...  
Keyword(s):  
Thrombotic Microangiopathy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Biomarkers

scholarly journals Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

2020 ◽  
Author(s):  
Weiping Ji ◽  
Gautam Bishnu ◽  
Zhenzhai Cai ◽  
Xian Shen
Keyword(s):  
Respiratory Tract ◽  
Serum Amyloid ◽  
Diagnosis And Treatment ◽  
Amyloid Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Epidemic Area ◽  
Systemic Symptoms ◽  
Novel Coronavirus ◽  
Potential Biomarkers

AbstractObjectiveBased on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.MethodsThe clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease, we found that the primary symptoms were fever, cough, fatigue, chest tightness, chest pain and specific blood test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.ResultsThe main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).ConclusionRespiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

scholarly journals Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

2020 ◽  
Author(s):  
Weiping Ji ◽  
Gautam Bishnu ◽  
Xian Shen ◽  
Zhenzhai Cai
Keyword(s):  
Respiratory Tract ◽  
Serum Amyloid ◽  
Diagnosis And Treatment ◽  
Amyloid Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Epidemic Area ◽  
Systemic Symptoms ◽  
Novel Coronavirus ◽  
Potential Biomarkers

Abstract Objective: Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.Methods: The clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease, we found that the primary symptoms were fever, cough, fatigue, chest tightness, chest pain and specific blood test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.Results: The main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).Conclusion: Respiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

scholarly journals C-reactive protein as a prognostic indicator in COVID-19 patients

2021 ◽  
Author(s):  
Mahmoud Sadeghi Haddad Zavareh ◽  
Masomeh Bayani ◽  
Mehran Shokri ◽  
Soheil Ebrahimpour ◽  
Arefeh Babazadeh ◽  
...  
Keyword(s):  
Serum Levels ◽  
Prognostic Indicator ◽  
Demographic Characteristics ◽  
Prognostic Indicators ◽  
Independent Factor ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Study Population ◽  
Potential Biomarkers

Abstract While some biomolecules have been explored to identify potential biomarkers for prognosis of the COVID-19 prognosis, there are no reliable prognostic indicators of disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe cases (n = 175) and nonsevere cases (n = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of ROC curve found that CRP could be used as an independent factor in predicting the severity of COVID-19 infection. Also, patients with CRP > 64.75 mg/L were more likely to have severe complications. The serum levels of CRP can predict the severity and progression of illness in patients with COVID-19.

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