Gluten Ataxia: Passive Transfer in a Mouse Model

2007 ◽  
Vol 1107 (1) ◽  
pp. 319-328 ◽  
Author(s):  
S. BOSCOLO ◽  
A. SARICH ◽  
A. LORENZON ◽  
M. PASSONI ◽  
V. RUI ◽  
...  
Keyword(s):  
Mouse Model ◽  
Passive Transfer ◽  
Gluten Ataxia

scholarly journals Human Malaria in Immunocompromised Mice

2000 ◽  
Vol 192 (11) ◽  
pp. 1653-1660 ◽  
Author(s):  
Edgar Badell ◽  
Claude Oeuvray ◽  
Alicia Moreno ◽  
Soe Soe ◽  
Nico van Rooijen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Synthetic Peptide ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Passive Transfer ◽  
Immunodeficient Mice ◽  
Low Concentrations ◽  
Erythrocyte Surface ◽  
Immunocompromised Mice

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect. Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falciparum parasitemia similarly to that reported in humans, but only when mice are concomitantly reconstituted with human monocytes (HuMNs). In contrast, neither HI-IgGs nor HuMNs alone had any direct effect upon parasitemia. We assessed the in vivo effect of epitope-specific human Abs affinity-purified on peptides derived either from the ring erythrocyte surface antigen (RESA) or the merozoite surface protein 3 (MSP3). The inoculation of low concentrations of anti-synthetic peptide from MSP3, but not of anti-RESA Abs, consistently suppressed P. falciparum in the presence of HuMNs. Parasitemia decrease was stronger and faster than that observed using HI-IgGs and as fast as that induced by chloroquine. Our observations demonstrate that this mouse model is of great value to evaluate the protective effect of different Abs with distinct specificity in the same animal, a step hardly accessible and therefore never performed before in humans.

scholarly journals Passive transfer autoimmunity in a mouse model of complex regional pain syndrome

Pain ◽  
2017 ◽  
Vol 158 (12) ◽  
pp. 2410-2421 ◽  
Author(s):  
Tian-Zhi Guo ◽  
Xiaoyou Shi ◽  
Wen-Wu Li ◽  
Tzuping Wei ◽  
John David Clark ◽  
...  
Keyword(s):  
Mouse Model ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Passive Transfer

scholarly journals Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model

Brain ◽  
2015 ◽  
Vol 138 (11) ◽  
pp. 3159-3167 ◽  
Author(s):  
Sukhvir Wright ◽  
Kevan Hashemi ◽  
Lukasz Stasiak ◽  
Julian Bartram ◽  
Bethan Lang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Passive Transfer

scholarly journals Antibody-Mediated Disease Remission in the Mouse Model of Lyme Borreliosis

2006 ◽  
Vol 74 (8) ◽  
pp. 4817-4825 ◽  
Author(s):  
Stephen W. Barthold ◽  
Emir Hodzic ◽  
Stefan Tunev ◽  
Sunlian Feng
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
Lyme Borreliosis ◽  
Dna Analysis ◽  
Passive Transfer ◽  
Immune Serum ◽  
Scid Mice ◽  
Disease Remission ◽  
Vascular Walls ◽  
Deficient Mice

ABSTRACT In the mouse model of Lyme borreliosis, the host immune response during infection with Borrelia burgdorferi results in the remission of carditis and arthritis, as well as global reduction of spirochete numbers in tissues, without elimination of infection (28). These events were recapitulated by passive transfer of immune serum from infected immunocompetent mice or T-cell-deficient mice to severe combined immunodeficient (SCID) mice. Previous studies have shown that immune serum is reactive against arthritis-related protein (Arp) and that Arp antiserum induces arthritis remission (16). However, although immune serum from T-cell-deficient mice induced disease remission, it was not reactive against Arp, suggesting that antibody to another antigen may be responsible. T-cell-deficient mouse immune serum was reactive to decorin binding protein A (DbpA). Therefore, DbpA antiserum was tested to determine its ability to induce disease remission in SCID mice. Antisera to Arp or DbpA induced both carditis and arthritis remission but did not significantly reduce spirochete numbers in tissues, based upon quantitative flaB DNA analysis, nor did treatment affect RNA levels of several genes, including arp and dbpA. Immunohistochemical labeling of spirochetes in hearts and joints during disease remission induced by adoptive transfer of lymphocytes, passive transfer of immune serum, or passive transfer of DbpA antiserum revealed that such treatment resulted in elimination of spirochetes from heart base and synovium but not vascular walls, tendons, or ligaments. These results suggest that Arp and DbpA antibodies may be active as disease-resolving components in immune serum but antibody against other antigens may be involved in reductions of spirochetes in tissues.

scholarly journals Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

2014 ◽  
Vol 11 (1) ◽  
pp. 16 ◽  
Author(s):  
Nithi Asavapanumas ◽  
Julien Ratelade ◽  
Marios C Papadopoulos ◽  
Jeffrey L Bennett ◽  
Marc H Levin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Immunoglobulin G ◽  
Passive Transfer ◽  
Experimental Mouse Model ◽  
Experimental Mouse

scholarly journals IgA Autoimmune Disorders: Development of a Passive Transfer Mouse Model

2004 ◽  
Vol 9 (1) ◽  
pp. 47-51 ◽  
Author(s):  
John J. Zone ◽  
C. Anthony Egan ◽  
Ted B. Taylor ◽  
Laurence J. Meyer
Keyword(s):  
Mouse Model ◽  
Passive Transfer ◽  
Autoimmune Disorders
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