scholarly journals Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol

2018 ◽  
Vol 60 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Eline H. van den Berg ◽  
Eke G. Gruppen ◽  
Richard W. James ◽  
Stephan J. L. Bakker ◽  
Robin P. F. Dullaart
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Paraoxonase 1 ◽  
Nonalcoholic Fatty Liver ◽  
Low Hdl ◽  
Serum Paraoxonase

scholarly journals Insulin Resistance in Nonalcoholic Fatty Liver Disease: Experience from Bangladesh

2016 ◽  
Vol 4 (2) ◽  
pp. 86-91 ◽  
Author(s):  
Golam Azam ◽  
Shahinul Alam ◽  
SKM Nazmul Hasan ◽  
Sheikh Mohammad Noor E Alam ◽  
Jahangir Kabir ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Model Assessment ◽  
Nonalcoholic Fatty Liver ◽  
Homeostatic Model Assessment ◽  
Low Hdl ◽  
Study Population

Background: Insulin resistance (IR) has largely been hypothesized as central in multifactorial pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study was aimed to explore the association of IR with NAFLD and nonalcoholic steatohepatitis (NASH).Methods: We enrolled 219 patients of NAFLD with sonographic evidence of fatty changes in liver excluding patients with alcohol intake and other causes of fatty change during June 2012 to July 2014.Liver biopsy was done for 110 patients with elevated ALT of >30 U/L for male and >18 U/L for female. We have measured IR by homeostatic model assessment of insulin resistance (HOMA-IR).Results: Age of the study population was 40.6 ± 10.0 years, male and female was 83 (37.9%) and 136 (62.1%), ALT was 42.0 (16-861) U/L, AST was 32 (16-608) U/L and GGT was 39 (10-243) U/L. According to Asian criteria 54 (25.9%) were non-obese, 139 (64.1%) had metabolic syndrome, 163 (74.8%) were hypertriglyceridemic, 200 (91.3%) had low HDL and 170 (77.4%) had high waist. Hypertensive and diabetic were 58 (26.7%) and 57 (26.1%) respectively. IR was 1.9±1.3 with the range of 0.4 to 9.3 and only 87 (39.7%) were above normal. Of the 110 biopsied, 65 (59.1%) had NASH. Normal and raised IR was associated with 32 (50.8%) and 33 (70.2%) NASH respectively (p < 0.05). Correlation between IR and steatosis, ballooning and fibrosis was not significant except lobular inflammation. IR was similar in NASH (2.2 ±1.6) and non NASH (1.9±1.6).Conclusion: Large proportion of NAFLD patients had normal IR. IR had inconsistent association with histological activity.Bangladesh Crit Care J September 2016; 4 (2): 86-91

Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease

2012 ◽  
Vol 19 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Mohammad Hashemi ◽  
Ali Bahari ◽  
Norallah Hashemzehi ◽  
Abdolkarim Moazeni-Roodi ◽  
Sara Shafieipour ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Serum Paraoxonase ◽  
Iranian Patients

scholarly journals Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Ya-Nan Zhang ◽  
Qin-Qiu Wang ◽  
Yi-Shu Chen ◽  
Chao Shen ◽  
Cheng-Fu Xu
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Ratio

Background/Aim. The risk factors for nonalcoholic fatty liver disease (NAFLD) in lean population have not been fully clarified. This study aimed to explore the association between uric acid to HDL-cholesterol ratio (UHR) and NAFLD in lean Chinese adults. Methods. A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m2) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. Results. Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P<0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P<0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P<0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. Conclusions. UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.

scholarly journals The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260994
Author(s):  
Yoo Min Han ◽  
Jooyoung Lee ◽  
Ji Min Choi ◽  
Min-Sun Kwak ◽  
Jong In Yang ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Metabolic Factors ◽  
Controlled Attenuation Parameter ◽  
Nonalcoholic Fatty Liver ◽  
Attenuation Parameter

Aim Existing studies have suggested an association between Helicobacter pylori (Hp) infection and nonalcoholic fatty liver disease (NAFLD). We investigated the relationship between Hp infection and NAFLD using controlled attenuation parameter (CAP) and other metabolic factors. Method We conducted a retrospective cohort study of apparently healthy individuals who underwent liver Fibroscan during health screening tests between January 2018 and December 2018. Diagnosis of Hp infection was based on a serum anti-Hp IgG antibody test and CAP values were used to diagnose NAFLD. Results Among the 1,784 subjects (mean age 55.3 years, 83.1% male), 708 (39.7%) subjects showed positive results of Hp serology. In the multivariate analysis, obesity (body mass index ≥25) (odds ratio [OR] 3.44, 95% confidence interval [CI] 2.75–4.29), triglyceride (OR 2.31, 95% CI 1.80–2.97), and the highest tertile of liver stiffness measurement (OR 2.08, 95% CI 1.59–2.71) were found to be associated with NAFLD, defined by CAP ≥248 dB/m, while Hp-seropositivity showed no association with NAFLD. Serum levels of HDL cholesterol significantly decreased in subjects with Hp-seropositivity compared to HP-seronegativity in both groups with and without NAFLD (P<0.001). Conclusion While Hp seropositivity was not associated with CAP-defined NAFLD, serum HDL cholesterol level were negatively associated with Hp-seropositivity in both groups with and without NAFLD. Further clinical and experimental studies are necessary to determine the association between Hp infection and NAFLD.

scholarly journals Association between Serum Uric Acid to HDL-cholesterol Ratio and Nonalcoholic Fatty Liver Disease among Chinese Adults

2021 ◽  
Author(s):  
Hui Zhao ◽  
Xia Qiu ◽  
Jiajia Cui ◽  
Yongye Sun
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Response Analysis ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

Abstract We conducted this case-control study to explore the association of serum uric acid (SUA) to HDL-cholesterol (HDL-C) ratio (UHR) with the risk of nonalcoholic fatty liver disease (NAFLD) in general Chinese adults. A total of 636 patients with NAFLD and 754 controls from affiliated hospital of Qingdao University in China between January to December 2016 were involved. NAFLD was diagnosed by ultrasonography after excluding other etiologies. The multivariable adjusted odds ratio and 95% confidence interval (CI) of NAFLD for the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In stratified analyses by sex and age, the positive associations between UHR and the risk of NAFLD were statistically significant in each subgroup. In stratified by BMI, the significant positive association was only found in the individuals with BMI≥23.9 kg/m2. Dose-response analysis indicated a linear positive correlation between UHR and NAFLD risk.

Abstract 17347: The Blood Triglyceride Level in Adolescence is Positively Associated With Nonalcoholic Fatty Liver Disease in Adulthood: The Kangwha Study

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Jung Hyun Lee ◽  
Su Jin Lee ◽  
Yong-Woo Jeon ◽  
Hyeon Chang Kim ◽  
Il Suh
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Ct Scan ◽  
Total Cholesterol ◽  
Nonalcoholic Fatty Liver Disease ◽  
Triglyceride Level ◽  
Fatty Liver Disease ◽  
Blood Lipids ◽  
Hdl Cholesterol ◽  
Nonalcoholic Fatty Liver

Introduction: Several studies have examined the association between blood lipids levels and fatty liver. However, there have been few longitudinal studies regarding the association between lipids level in adolescence and nonalcoholic fatty liver disease in adulthood. Hypothesis: We assessed the hypothesis that blood lipids level in adolescence is associated with nonalcoholic fatty liver in adulthood. Methods: The Kangwha Study was a community-based prospective cohort study that started in 1986 in Kangwha County. A total of 269 participants (148 men; 121 women) were enrolled in our study after excluding heavy drinkers in adulthood, where their blood fasting total cholesterol, triglyceride, and high density lipoprotein (HDL) cholesterol level were measured at least once during adolescence (1992-1996), and the fatty liver was assessed by computed tomography (CT) scan in adulthood (2014-2017). A fatty liver was defined as a liver with values, at least, equal to or larger than 10 of difference between hounsfield unit (HU) of spleen and HU of liver, by measuring CT scan images at L1 vertebral level. For evaluating the association between lipids level at adolescence and fatty liver in adulthood, we used multiple logistic regressions. The fitness of models was evaluated by Hosmer and Lemeshow test. Results: The presence of fatty liver in adulthood was 5.6% (15 of 269). Mean age of study participants at enrollment is 13.9 years (SD, 1.6 years), and that in adulthood is 36.1 years (SD, 0.8 years). When adjusted for age, sex, body mass index, and blood pressure in adolescence, the adjusted odds ratio (aOR) of total cholesterol was 0.83 for 10 mg/dl increment (95% confidence interval (CI), 0.63-1.11), that of triglyceride was 1.17 for 10 mg/dl increment (95% CI, 1.02-1.35), and that of HDL cholesterol was 1.77 for 10 mg/dl increment (95% CI, 0.78-4.01). Our model satisfied the goodness of fit (p=0.75). Conclusions: In conclusion, the blood triglyceride level in adolescence is positively associated with nonalcoholic fatty liver disease in adulthood, but blood total and HDL cholesterol level is not. The results of our study supported the usefulness of lipid measurements in adolescence.

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