scholarly journals Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation

2019 ◽  
Vol 60 (4) ◽  
pp. 880-891 ◽  
Author(s):  
Jihong Lian ◽  
Russell Watts ◽  
Ariel D. Quiroga ◽  
Megan R. Beggs ◽  
R. Todd Alexander ◽  
...  
Keyword(s):  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Triacylglycerol Accumulation ◽  
Hepatic Triacylglycerol ◽  
High Sucrose

scholarly journals Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats

2005 ◽  
Vol 93 (6) ◽  
pp. 957-963 ◽  
Author(s):  
Keiichiro Sugimoto ◽  
Junko Suzuki ◽  
Kazuya Nakagawa ◽  
Shuichi Hayashi ◽  
Toshiki Enomoto ◽  
...  
Keyword(s):  
Eucalyptus Globulus ◽  
Leaf Extract ◽  
Elevated Concentration ◽  
Dependent Manner ◽  
High Fructose ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Hepatic Triacylglycerol ◽  
Dose Dependent ◽  
High Sucrose

Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75 % in calorie base) with or without ELE (10 g/kg diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (sd 37·9)v. 392 (sd 26·0) g (n7);P<0·05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1·44 (sd 0·448)v.2·79 (sd 0·677) mmol/l (n7);P<0·05) and liver (19·1 (sd 5·07)v.44·1 (sd 16·28) μmol/g (n7);P<0·05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 min after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, which inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1723-P
Author(s):  
IRENA MARKOVÁ ◽  
MARTINA HÜTTL ◽  
HANA MALINSKA ◽  
ONDREJ SEDA ◽  
LUDMILA KAZDOVA
Keyword(s):  
Metabolic Syndrome ◽  
Sucrose Diet ◽  
Transcriptomic Signature ◽  
High Sucrose Diet ◽  
High Sucrose

Motor learning impairment in rats under a high sucrose diet

2021 ◽  
Vol 234 ◽  
pp. 113384
Author(s):  
Nayely Flores-Fuentes ◽  
Carolina Hernandez-Cruz ◽  
Karina Bermeo ◽  
Antonio Barajas-Martinez ◽  
Valeria Nayely Hernandez-Serratos ◽  
...  
Keyword(s):  
Motor Learning ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Learning Impairment ◽  
High Sucrose

scholarly journals Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sang Hyuk Lee ◽  
Eunjoo Cho ◽  
Sung-Eun Yoon ◽  
Youngjoon Kim ◽  
Eun Young Kim
Keyword(s):  
Locomotor Behavior ◽  
Sensory Inputs ◽  
Sucrose Diet ◽  
High Nutrient ◽  
Intracellular Ca ◽  
High Sucrose Diet ◽  
Locomotor Activities ◽  
Locomotor Behaviors ◽  
High Sucrose ◽  
Over Time

AbstractMetabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

Effects on Serum Lipids of Different Dietary Fats Associated with a High Sucrose Diet

1973 ◽  
Vol 44 (6) ◽  
pp. 601-604 ◽  
Author(s):  
J. I. Mann ◽  
G. S. Watermeyer ◽  
E. B. Manning ◽  
J. Randles ◽  
A. S. Truswell
Keyword(s):  
Serum Lipids ◽  
Saturated Fat ◽  
Dietary Fats ◽  
Complex Carbohydrate ◽  
The Third ◽  
Sucrose Diet ◽  
Daily Energy ◽  
Dietary Period ◽  
High Sucrose Diet ◽  
High Sucrose

1. Each of nine volunteers was fed three different diets. The percentage of total daily energy provided by fat, carbohydrate and protein remained constant, but the nature of the fat and carbohydrate was altered. The first diet contained ordinary amounts of sucrose and predominantly saturated fat. During the second dietary period, fat remained saturated, but the quantity of sucrose was increased at the expense of complex carbohydrate. In the third dietary period, the sucrose intake remained high, but fat was supplied chiefly in the polyunsaturated form. 2. A small but statistically significant increase of serum fasting cholesterol and triglyceride was observed during the second dietary period, but on the third diet levels of both lipids fell to concentrations not significantly different from those seen on the first diet.

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