scholarly journals Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques

2018 ◽  
Vol 59 (11) ◽  
pp. 2075-2083 ◽  
Author(s):  
G. M. Anantharamaiah ◽  
David W. Garber ◽  
Dennis Goldberg ◽  
Eric Morrel ◽  
Geeta Datta ◽  
...  
2019 ◽  
Vol 62 ◽  
pp. 103548
Author(s):  
Hao Wang ◽  
Zhen-ou Sun ◽  
Rizwan ur-Rehman ◽  
Sania Riaz ◽  
Ting-Ting Shen ◽  
...  

1981 ◽  
Vol 10 (3) ◽  
pp. 364-370 ◽  
Author(s):  
Richard F. Heller ◽  
Hugh D. Tunstall Pedoe ◽  
Geoffrey Rose

BioFactors ◽  
2008 ◽  
Vol 33 (3) ◽  
pp. 211-223 ◽  
Author(s):  
Akiko Yasuda ◽  
Midori Natsume ◽  
Kazue Sasaki ◽  
Seigo Baba ◽  
Yuko Nakamura ◽  
...  

2007 ◽  
Vol 98 (3) ◽  
pp. 550-555 ◽  
Author(s):  
Xiaoming Jia ◽  
Naoyuki Ebine ◽  
Isabelle Demonty ◽  
Yanwen Wang ◽  
Robin Beech ◽  
...  

The hypolipidaemic effects of plant sterols are well established. However, mechanisms by which plant sterols lower plasma cholesterol levels, particularly at the molecular level, have not been clearly elucidated. The objective of the present study was to determine whether different plant sterol analogues reduce plasma cholesterol levels by up regulating the sterol transporters ABCG5 and ABCG8 in the liver and/or small intestine. Male Golden Syrian hamsters were divided into eight groups. Groups 1 and 2 were fed a maize starch–casein–sucrose-based diet that did not contain cholesterol (control; Con) or the Con diet with the addition of 0·25 % cholesterol (Ch-Con). Groups 3–8 were fed the Ch-Con diet supplemented with 1 % plant sterols, 1 % plant stanols, 1 % of a plant sterol and stanol mixture (50:50), 1·76 % plant sterol–fish oil esters, or 0·71 or 1·43 % stanol–ascorbic acid esters, respectively. After 5 weeks, the Ch-Con diet up regulated the ABCG5 mRNA expression and tended (P = 0·083) to increase ABCG8 mRNA expression in the liver, but did not affect both genes’ expression in the small intestine compared with the Con diet. Hamsters fed 0·7 % stanol esters showed lower plasma cholesterol levels (P < 0·001) and also lower liver ABCG5 mRNA expression (P < 0·05) compared with the Ch-Con diet. Plant stanols, stanol esters, and sterol esters did not affect the ABCG5 or ABCG8 mRNA expressions in the liver and intestine although they reduced plasma cholesterol levels. These results suggest that plant sterols and their derivatives reduce plasma cholesterol levels independently from the mRNA expression of ABCG5 and ABCG8 transporters.


1998 ◽  
Vol 128 (6) ◽  
pp. 954-959 ◽  
Author(s):  
Elizabeth A. Kirk ◽  
Phuong Sutherland ◽  
Shari A. Wang ◽  
Alan Chait ◽  
Renee C. LeBoeuf

2021 ◽  
Vol 112 ◽  
pp. 106369
Author(s):  
Purnima Gunness ◽  
Honglei Zhai ◽  
Barbara A. Williams ◽  
Dagong Zhang ◽  
Michael J. Gidley

2020 ◽  
Vol 11 (3) ◽  
pp. 2163-2172 ◽  
Author(s):  
Yimin Zhao ◽  
Zouyan He ◽  
Wangjun Hao ◽  
Hanyue Zhu ◽  
Ning Liang ◽  
...  

Vinegars reduce plasma cholesterol in hamsters given a high cholesterol diet.


1992 ◽  
Vol 122 (11) ◽  
pp. 2292-2297 ◽  
Author(s):  
Linji Wang ◽  
Rosemary K. Newman ◽  
C. Walter Newman ◽  
Petrea J. Hofer

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