scholarly journals Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins

2013 ◽  
Vol 54 (10) ◽  
pp. 2623-2635 ◽  
Author(s):  
Irina G. Stavrovskaya ◽  
Susan S. Bird ◽  
Vasant R. Marur ◽  
Matthew J. Sniatynski ◽  
Sergei V. Baranov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Fatty Acyl ◽  
Acyl Composition ◽  
Fatty Acyl Composition

scholarly journals Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Irina G Stavrovskaya ◽  
Susan S. Bird ◽  
Vasant R. Marur ◽  
Matthew J. Sniatynski ◽  
Sergei V. Baranov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Fatty Acyl ◽  
Acyl Composition ◽  
Fatty Acyl Composition

Effect of membrane fatty acyl composition on LDL metabolism in Hep G2 hepatocytes

Biochemistry ◽  
1990 ◽  
Vol 29 (28) ◽  
pp. 6626-6632 ◽  
Author(s):  
Paul Kuo ◽  
Mark Weinfeld ◽  
Joseph Loscalzo
Keyword(s):  
Fatty Acyl ◽  
Hep G2 ◽  
Acyl Composition ◽  
Fatty Acyl Composition

Altered phospholipid metabolism in pressure-overload hypertrophied hearts

1986 ◽  
Vol 250 (1) ◽  
pp. H1-H6 ◽  
Author(s):  
D. K. Reibel ◽  
B. O'Rourke ◽  
K. A. Foster ◽  
H. Hutchinson ◽  
C. E. Uboh ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Pressure Overload ◽  
Phospholipid Metabolism ◽  
Fatty Acyl ◽  
Membrane Function ◽  
Acyl Composition ◽  
Fatty Acyl Composition ◽  
Abdominal Aortic ◽  
Individual Phospholipid Class ◽  
The Individual

The content and fatty acyl composition of phospholipids were examined in pressure-overload hypertrophied hearts. Cardiac hypertrophy was induced in rats by abdominal aortic constriction. Twenty-one days postconstriction the content of myocardial phosphatidylcholine (PC), sphingomyelin, and phosphatidylinositol (PI) was significantly elevated by 10, 10, and 20%, respectively. The essential fatty acid, linoleic acid, was markedly reduced in PC, phosphatidylethanolamine (PE), PI, and cardiolipin (CL) of hypertrophied hearts. The associated changes in fatty acyl composition were specific for the individual phospholipid class as evidenced by a significant elevation of palmitic acid in PC, docosahexaenoic acid in PE and oleic acid in CL. Alterations in fatty acyl composition of phospholipids were associated with no change in the composition of cardiac triglycerides, cardiac free fatty acids or serum lipids. The fatty acyl composition of phospholipids was also altered in pressure-overload hypertrophied hearts of cats, as evidenced by a reduction of linoleic acid and an elevation of arachidonic acid in total phospholipids. These findings demonstrate that changes in phospholipid metabolism occur in the pressure-overloaded mammalian heart. Such alterations may contribute to altered membrane function in the hypertrophied myocardium.

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