scholarly journals Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

2012 ◽  
Vol 53 (12) ◽  
pp. 2667-2676 ◽  
Author(s):  
Sabrina A. Bardowell ◽  
Xinxin Ding ◽  
Robert S. Parker
Keyword(s):  
Vitamin E ◽  
Vitamin E Status

scholarly journals Breeder Diet Strategies for Generating Ttpa-Null and Wild-Type Mice with Low Vitamin E Status to Assess Neurological Outcomes

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Katherine M Ranard ◽  
Matthew J Kuchan ◽  
John W Erdman
Keyword(s):  
Animal Model ◽  
Vitamin E ◽  
Mouse Model ◽  
Wild Type ◽  
Future Studies ◽  
Neurological Outcomes ◽  
Transfer Protein ◽  
And Function ◽  
The Brain ◽  
Vitamin E Status

ABSTRACT Studying vitamin E [α-tocopherol (α-T)] metabolism and function in the brain and other tissues requires an animal model with low α-T status, such as the transgenic α-T transfer protein (Ttpa)–null (Ttpa−/−) mouse model. Ttpa+/− dams can be used to produce Ttpa−/− and Ttpa+/+mice for these studies. However, the α-T content in Ttpa+/− dams’ diet requires optimization; diets must provide sufficient α-T for reproduction, while minimizing the transfer of α-T to the offspring destined for future studies that require low baseline α-T status. The goal of this work was to assess the effectiveness and feasibility of 2 breeding diet strategies on reproduction outcomes and offspring brain α-T concentrations. These findings will help standardize the breeding methodology used to generate the Ttpa−/− mice for neurological studies.

scholarly journals Selenium and Vitamin E Status: Impact on Viral Pathogenicity

2007 ◽  
Vol 137 (5) ◽  
pp. 1338-1340 ◽  
Author(s):  
Melinda A. Beck
Keyword(s):  
Vitamin E ◽  
Vitamin E Status

Oxidation resistance of LDL is correlated with vitamin E status in β-thalassemia intermedia

1998 ◽  
Vol 137 (2) ◽  
pp. 429-435 ◽  
Author(s):  
Luisa Tesoriere ◽  
Daniele D'Arpa ◽  
Aurelio Maggio ◽  
Vita Giaccone ◽  
Elisa Pedone ◽  
...  
Keyword(s):  
Vitamin E ◽  
Oxidation Resistance ◽  
Thalassemia Intermedia ◽  
Vitamin E Status

scholarly journals Vitamin E status in healthy population in Asia: a review of current literature

2019 ◽  
pp. 1-14
Author(s):  
Anku Malik ◽  
Manfred Eggersdorfer ◽  
Geeta Trilok-Kumar
Keyword(s):  
Vitamin E ◽  
Physiological State ◽  
Age Groups ◽  
Health Conditions ◽  
Healthy Population ◽  
Asian Countries ◽  
The Past ◽  
Conclusive Data ◽  
Vitamin E Status ◽  
Lipid Soluble Antioxidant

Abstract. Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian countries, including India. Part of the problem is lack of validated biomarkers for vitamin E and no consensus on cut offs for defining deficiency and sufficiency. Thus, interpretation of the data on the vitamin E status is difficult. Limited available data from 31 studies on vitamin E status in healthy people from Asia, the most populated continent, has been collated for the purpose of this review. Broadly, the results suggest inadequate vitamin E status in most age groups, with the prevalence of deficiency reaching 67%, 80%, 56% and 72% in infants, children and adolescents, adults, elderly and pregnant women, respectively, based on varying cut offs. The findings are not surprising as both, vitamin E intakes and its status have not received too much attention in the past. Lack of conclusive data accentuates the need for more research on the vitamin E status across all age groups and to define age, gender and physiological state specific cut offs for vitamin E levels.

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