scholarly journals Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

2011 ◽  
Vol 52 (9) ◽  
pp. 1723-1732 ◽  
Author(s):  
David W. Nelson ◽  
Yu Gao ◽  
Nicole M. Spencer ◽  
Taylor Banh ◽  
Chi-Liang Eric Yen
Keyword(s):  
Weight Gain ◽  
Energy Expenditure ◽  
Obese Mice ◽  
High Fat ◽  
Excessive Weight Gain ◽  
Excessive Weight ◽  
Fat Feeding

scholarly journals Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet

2019 ◽  
Vol 7 (1) ◽  
pp. e000783 ◽  
Author(s):  
Liang Xu ◽  
Naoto Nagata ◽  
Guanliang Chen ◽  
Mayumi Nagashimada ◽  
Fen Zhuge ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Chronic Inflammation ◽  
Plasma Levels ◽  
High Fat Diet ◽  
Macrophage Activation ◽  
Low Grade ◽  
Obese Mice ◽  
High Fat

ObjectiveWe reported previously that empagliflozin—a sodium-glucose cotransporter (SGLT) 2 inhibitor—exhibited preventive effects against obesity. However, it was difficult to extrapolate these results to human subjects. Here, we performed a therapeutic study, which is more relevant to clinical situations in humans, to investigate antiobesity effects of empagliflozin and illustrate the mechanism underlying empagliflozin-mediated enhanced fat browning in obese mice.Research design and methodsAfter 8 weeks on a high-fat diet (HFD), C57BL/6J mice exhibited obesity, accompanied by insulin resistance and low-grade chronic inflammation. Cohorts of obese mice were continued on the HFD for an additional 8-week treatment period with or without empagliflozin.ResultsTreatment with empagliflozin for 8 weeks markedly increased glucose excretion in urine, and suppressed HFD-induced weight gain, insulin resistance and hepatic steatosis. Notably, empagliflozin enhanced oxygen consumption and carbon dioxide production, leading to increased energy expenditure. Consistently, the level of uncoupling protein 1 expression was increased in both brown and white (WAT) adipose tissues of empagliflozin-treated mice. Furthermore, empagliflozin decreased plasma levels of interleukin (IL)-6 and monocyte chemoattractant protein-1, but increased plasma levels of IL-33 and adiponectin in obese mice. Finally, we found that empagliflozin reduced M1-polarized macrophage accumulation, while inducing the anti-inflammatory M2 phenotype of macrophages in the WAT and liver, thereby attenuating obesity-related chronic inflammation.ConclusionsTreatment with empagliflozin attenuated weight gain by increasing energy expenditure and adipose tissue browning, and alleviated obesity-associated inflammation and insulin resistance by alternative macrophage activation in the WAT and liver of obese mice.

scholarly journals Intact vagal gut‐brain signalling prevents hyperphagia and excessive weight gain in response to high‐fat high‐sugar diet

2020 ◽  
Author(s):  
Molly McDougle ◽  
Danielle Quinn ◽  
Charlene Diepenbroek ◽  
Arashdeep Singh ◽  
Claire de la Serre ◽  
...  
Keyword(s):  
Weight Gain ◽  
High Fat ◽  
Excessive Weight Gain ◽  
High Sugar ◽  
Excessive Weight

The role of antenatal education for the prevention of excessive weight gain during pregnancy

2020 ◽  
Vol 71 (6) ◽  
Author(s):  
Roberta Amadori ◽  
Carmela Melluzza ◽  
Alessia Motta ◽  
Alberto De Pedrini ◽  
Daniela Surico
Keyword(s):  
Weight Gain ◽  
Excessive Weight Gain ◽  
Antenatal Education ◽  
Excessive Weight ◽  
Weight Gain During Pregnancy

Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg

2020 ◽  
Vol 33 (8) ◽  
pp. 995-1002
Author(s):  
Valeria Calcaterra ◽  
Corrado Regalbuto ◽  
Matteo Manuelli ◽  
Catherine Klersy ◽  
Gloria Pelizzo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Weight Gain ◽  
Autoimmune Diseases ◽  
Medical History ◽  
Unknown Origin ◽  
Overweight And Obesity ◽  
Excessive Weight Gain ◽  
Familial Predisposition ◽  
Excessive Weight ◽  
Hla Dq2

AbstractObjectivesThe coexistence of celiac disease (CD) and obesity/overweight is not unusual. We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain.MethodsWe enrolled 200 children referred for overweight/obesity to our outpatient clinic. Medical history during pregnancy and childhood and lifestyle variables were recorded. Patients were screened for CD with total immunoglobulin A (IgA), IgA anti-transglutaminase (tTG-IgA) and IgA anti-endomysial antibodies (EMA-IgA). In subjects with positive autoantibodies, esophagogastroduodenoscopy (EGDS) was performed and genetic testing for HLA DQ2 and/or DQ8 haplotypes was tested.ResultsCD positive antibodies (tTg-IgA and EMA-IgA) were detected in eight patients (4%); in all subjects CD diagnosis was confirmed by HLA-DQ2 and/or DQ8 compatibility and EGDS. No association between CD and medical history during pregnancy and childhood or lifestyle variables was noted; however, a dietary difference was identified with those testing positive for CD also reporting a lower weekly consumption of fruits and vegetables (p=0.04). Headache was reported more frequently in patients with than without CD (p=0.04). Familiar positivity for autoimmune diseases was revealed in CD patients (p=0.01).ConclusionCD should be considered in children with excessive weight gain. Familial predisposition to other autoimmune diseases may represent a risk factor for development of CD. Even though the relationship between headache and CD is not well defined, the patients with headache of unknown origin should be screened for CD.

scholarly journals Family sociodemographic characteristics as correlates of children’s breakfast habits and weight status in eight European countries. The ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project

2014 ◽  
Vol 18 (5) ◽  
pp. 774-783 ◽  
Author(s):  
Yannis Manios ◽  
George Moschonis ◽  
Odysseas Androutsos ◽  
Christina Filippou ◽  
Wendy Van Lippevelde ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Balance ◽  
Weight Status ◽  
Educational Status ◽  
European Countries ◽  
Sociodemographic Characteristics ◽  
Excessive Weight Gain ◽  
Breakfast Consumption ◽  
Mediation Analyses ◽  
Excessive Weight

AbstractObjectiveThe purpose of the present study was to investigate the associations of family sociodemographic characteristics with children’s weight status and whether these potential associations are mediated by children’s breakfast habits.DesignA school-based survey among 10–12-year-old children was conducted in eight European countries. Children’s weight and height were measured and breakfast habits and family sociodemographic characteristics were self-reported by 5444 children and their parents. International Obesity Task Force cut-off points were used to categorize children as overweight/obese or normal weight. Mediation analyses were used to test the potential mediating effect of children’s breakfast consumption on the associations between family sociodemographic characteristics and children’s overweight/obesity.SettingSchools in eight European countries participating in the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project.SubjectsChildren aged 10–12 years and their parents (n 5444).ResultsChildren’s reported daily breakfast consumption varied from 56 % in Slovenia to 92 % in Spain on weekdays and from 79 % in Greece to 93 % in Norway on weekends. Children of native parents, with both parents employed and with at least one parent having more than 14 years of education were more likely to consume breakfast daily and less likely to be overweight/obese. Finally, mediation analyses revealed that the association of parental nationality and parental educational status with children’s overweight/obesity was partially mediated by children’s daily breakfast consumption.ConclusionsThe study shows that the lower likelihood of being overweight/obese among 10–12-year-old children of native background and higher parental educational status was partially mediated by children’s daily breakfast consumption.

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