scholarly journals Hyperglycemic Ins2AkitaLdlr−/−mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease

2011 ◽  
Vol 52 (8) ◽  
pp. 1483-1493 ◽  
Author(s):  
Changcheng Zhou ◽  
Brian Pridgen ◽  
Nakesha King ◽  
Jinxian Xu ◽  
Jan L. Breslow
Keyword(s):  
Macrovascular Disease ◽  
Lipid Levels ◽  
Elevated Lipid ◽  
Diabetic Macrovascular Disease

scholarly journals Effect of Polyherbal Mixtures on the Treatment of Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Aparajeya Panda ◽  
Somanatha Jena ◽  
Pramod Kumar Sahu ◽  
Sanghamitra Nayak ◽  
Payodhar Padhi
Keyword(s):  
Blood Glucose ◽  
Elevated Level ◽  
Treated Group ◽  
Diabetic Rats ◽  
Lipid Levels ◽  
Beneficial Effects ◽  
Estimated Parameters ◽  
Treatment Of Diabetes ◽  
Dose Levels ◽  
Elevated Lipid

The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures.

scholarly journals Risk of future microvascular and macrovascular disease in people with Type 1 diabetes of very long duration: a national study with 10-year follow-up

2016 ◽  
Vol 34 (3) ◽  
pp. 411-418 ◽  
Author(s):  
S. Adamsson Eryd ◽  
A.-M. Svensson ◽  
S. Franzén ◽  
B. Eliasson ◽  
P. M. Nilsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Macrovascular Disease ◽  
National Study ◽  
Long Duration

Plasma lipid levels and nutritional intake in childhood- and adolescence-onset young type 1 diabetic patients in Japan

2006 ◽  
Vol 73 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Mieko Saito ◽  
Hiromi Kuratsune ◽  
Hayami Nitta ◽  
Kazue Kawahara ◽  
Masahiro Hamano ◽  
...  
Keyword(s):  
Plasma Lipid ◽  
Nutritional Intake ◽  
Diabetic Patients ◽  
Childhood And Adolescence ◽  
Lipid Levels ◽  
Type 1 Diabetic Patients

Adolescence and emerging adulthood

2016 ◽  
Author(s):  
David Levy
Keyword(s):  
Smoking Cessation ◽  
Glycaemic Control ◽  
General Population ◽  
Emerging Adulthood ◽  
Early Onset ◽  
Microvascular Complications ◽  
Macrovascular Disease ◽  
The Past ◽  
Adult Diabetes

Adolescence and emerging childhood forms an increasing proportion of the lifespan of urbanized individuals. Glycaemic control worsens during adolescence; physiology and psychology contribute. A1C levels peak around 9% (75 mmol/mol) before declining from late teens onwards. However, unchanging glycaemia (tracking) is common. Glycaemia has generally improved in the past 10–15 years, but significant differences between and within countries persist. Microvascular complications are prevalent at this stage, but have probably also decreased with time. During this important period, the stage can be set for premature macrovascular disease (early onset hypertension, arterial stiffening, dyslipidaemia, and smoking). Exercise reduces the risk of microvascular complications. Smoking is as common in young Type 1 patients than in the general population. Efforts at smoking cessation need reinforcing. Glycaemic control during university does not improve. Transition from paediatric to adult diabetes services is often unsatisfactory; clinics should implement simple procedures focusing on accessibility, flexibility, and improved communications.

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