scholarly journals Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport

2010 ◽  
Vol 51 (12) ◽  
pp. 3443-3454 ◽  
Author(s):  
Eric J. Niesor ◽  
Christine Magg ◽  
Naoto Ogawa ◽  
Hiroshi Okamoto ◽  
Elisabeth von der Mark ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Protein Activity ◽  
Transfer Protein

scholarly journals Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport

Circulation ◽  
2007 ◽  
Vol 116 (11) ◽  
pp. 1267-1273 ◽  
Author(s):  
Hiroyuki Tanigawa ◽  
Jeffrey T. Billheimer ◽  
Jun-ichiro Tohyama ◽  
YuZhen Zhang ◽  
George Rothblat ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Transfer Protein

Reverse cholesterol transport in mice expressing simian cholesteryl ester transfer protein

2002 ◽  
Vol 164 (1) ◽  
pp. 73-78 ◽  
Author(s):  
O Stein ◽  
Y Dabach ◽  
G Hollander ◽  
M Ben-Naim ◽  
G Halperin ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Transfer Protein

Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport

2001 ◽  
Vol 159 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Zhongyan Zhang ◽  
Shizuya Yamashita ◽  
Ken-ichi Hirano ◽  
Yumiko Nakagawa-Toyama ◽  
Akifumi Matsuyama ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Transfer Protein ◽  
Atherosclerotic Lesions

scholarly journals Forhidrol, a bioactive fraction of Phaleria macrocarpa (Scheff.) Boerl., increases reverse cholesterol transport pathway by down-regulation of cholesteryl ester transfer protein activity

2018 ◽  
Vol 91 (1) ◽  
Author(s):  
Guntur Berlian ◽  
Olivia M. Tandrasasmita ◽  
Dwi A.S. Suciptan ◽  
Raymond R. Tjandrawinata
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Density Lipoprotein ◽  
Cholesterol Transport ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Transfer Protein ◽  
Phaleria Macrocarpa ◽  
Bioactive Fraction

Phaleria macrocarpa (Scheff.) Boerl. is one of the most popular medicinal plants in Indonesia. This plant has traditionally been used to lower cholesterol and control hypertension. This study was performed to examine the effect of Forhidrol, a bioactive fraction of P. macrocarpa (Scheff.) Boerl., to increase reverse cholesterol transport through the down-regulation of cholesteryl ester transfer protein (CETP) activity in hepatocellular carcinoma cell lines. Measurement of target genes including liver X receptor (LXR), sterol regulatory element-binding protein 1 (SREBP1), scavenger receptor class B type 1, low-density lipoprotein (LDL) receptor, apolipoprotein B, CYP11B1, CYP11B2, peroxisome proliferatoractivated receptor α (PPARα), peroxisome proliferator-activated receptor δ (PPARδ) and peroxisome proliferator-activated receptor γ (PPARγ) were done using realtime polymerase chain reaction assay. Secreted CETP and apolipoprotein A-1 were analyzed using western blot. CETP activity in vitro was measured using CETP inhibitor drug screening kit and triglyceride synthesis was measured using enzyme-linked immunosorbent assay. Forhidrol was found to significantly down-regulate CETP mRNA expression, as well as total CETP and cholesteryl esters transfer activity (P<0.05). It specifically reduced transcriptional level of regulatory genes of CETP promoter including SREBP-1 and LXR. Forhidrol also significantly increased PPARδ and PPARα expression (P<0.05) and slightly repressed triglycerides synthesis. In vivo study showed elevated high-density lipoprotein (HDL) levels in rabbits after 4-week treatment of Forhidrol at a dose of 37.5 mg/1.5 kg body weight compared to placebo. Conversely, LDL, triglyceride and CETP activity were decreased. Forhidrol increased HDL levels by reducing CETP-dependent transfer of cholesterol from HDL to LDL particles. Looking at possible side effects, Forhidrol apparently acted as a safe agent without negative effect towards blood pressure. These findings suggested that Forhidrol may be further developed as a potential anti-atherogenic drug.

scholarly journals The effect of cholesteryl ester transfer protein overexpression and inhibition on reverse cholesterol transport

2007 ◽  
Vol 77 (4) ◽  
pp. 732-739 ◽  
Author(s):  
Urbain Tchoua ◽  
Wilissa D'Souza ◽  
Nigora Mukhamedova ◽  
Denise Blum ◽  
Eric Niesor ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Protein Overexpression ◽  
Transfer Protein
Sign in / Sign up

Export Citation Format

Share Document