scholarly journals Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice

2010 ◽  
Vol 51 (11) ◽  
pp. 3230-3242 ◽  
Author(s):  
Youcai Zhang ◽  
Curtis D. Klaassen
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Composition ◽  
Bile Acid Sequestrant ◽  
Hepatic Bile

scholarly journals Hepatic versus gallbladder bile composition: in vivo transport physiology of the gallbladder in rainbow trout

2000 ◽  
Vol 278 (6) ◽  
pp. R1674-R1684 ◽  
Author(s):  
M. Grosell ◽  
M. J. O'Donnell ◽  
C. M. Wood
Keyword(s):  
Rainbow Trout ◽  
Bile Acid ◽  
Oncorhynchus Mykiss ◽  
Bile Acids ◽  
Bile Flow ◽  
Gallbladder Bile ◽  
Apical Surface ◽  
Hepatic Bile ◽  
Bile Composition

Ion and water transport across the teleost Oncorhynchus mykiss gallbladder were studied in vivo by comparing flow and composition of hepatic bile, collected by chronic catheter, to volume and composition of terminally collected gallbladder bile. Differences in composition were comparable with those of other vertebrates, whereas bile flow (75 μl ⋅ kg− 1 ⋅ h− 1) was below values reported for endothermic vertebrates. The gallbladder concentrates bile acids five- to sevenfold and exhibits higher net Cl− than Na+ transport in vivo, in contrast to the 1:1 transport ratio from gallbladders under saline/saline conditions. Transepithelial potential (TEP) in the presence of bile, at the apical surface, was −13 mV (bile side negative) but +1.5 mV in the presence of saline. Bile acid in the apical saline reversed the TEP, presumably by a Donnan effect. We propose that ion transport across the gallbladder in vivo involves backflux of Na+ from blood to bile resulting in higher net Cl− than Na+ flux. This Na+backflux is driven by a bile side negative TEP and low Na+activity in bile due to the complexing effects of bile acids.

SK&F 97426-A: A Novel Bile Acid Sequestrant with Higher Affinities and Slower Dissociation Rates for Bile Acids in vitro Than Cholestyramine

1997 ◽  
Vol 86 (1) ◽  
pp. 76-81 ◽  
Author(s):  
G. Martin Benson ◽  
David R. Alston ◽  
Deirdre M.B. Hickey ◽  
Albert A. Jaxa-Chamiec ◽  
Caroline M. Whittaker ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Bile Acid Sequestrant

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

Heart ◽  
2013 ◽  
Vol 99 (22) ◽  
pp. 1685-1692 ◽  
Author(s):  
Peter P Rainer ◽  
Uwe Primessnig ◽  
Sandra Harenkamp ◽  
Bernhard Doleschal ◽  
Markus Wallner ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Bile Acid ◽  
Bile Acids ◽  
Acid Composition ◽  
Serum Bile Acid ◽  
Atrial Myocardium ◽  
Altered Serum

scholarly journals Relationship between bile acid composition in bile and gallstone formation in mice fed a diet containing various bile acids

1983 ◽  
Vol 33 ◽  
pp. 284
Author(s):  
Yukio Fujino ◽  
Takara Yonaga ◽  
Ryoji Tamura ◽  
Kyoji Kurabayashi ◽  
Kuniyoshi Yoshimura
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Composition ◽  
Gallstone Formation

FRI-107-Emerging role of taurine conjugated bile acids in the gut liver axis and on hepatic bile acid receptors in chronic hepatitis C

2019 ◽  
Vol 70 (1) ◽  
pp. e434-e435
Author(s):  
Rabab Oun Ali Anwar Ali ◽  
Gabriella quinn ◽  
kareen hill ◽  
Grace Zhang ◽  
Christopher Koh ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Bile Acid ◽  
Hepatitis C ◽  
Bile Acids ◽  
Chronic Hepatitis C ◽  
Hepatic Bile ◽  
Bile Acid Receptors ◽  
Conjugated Bile Acids

scholarly journals Microbiota transplantation restores normal fecal bile acid composition in recurrentClostridium difficileinfection

2014 ◽  
Vol 306 (4) ◽  
pp. G310-G319 ◽  
Author(s):  
Alexa R. Weingarden ◽  
Chi Chen ◽  
Aleh Bobr ◽  
Dan Yao ◽  
Yuwei Lu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Composition ◽  
Bile Salts ◽  
Bile Acid Metabolism ◽  
Rrna Gene ◽  
Fecal Bile Acid ◽  
Bacterial Composition ◽  
Fecal Samples ◽  
Secondary Bile Acids

Fecal microbiota transplantation (FMT) has emerged as a highly effective therapy for refractory, recurrent Clostridium difficile infection (CDI), which develops following antibiotic treatments. Intestinal microbiota play a critical role in the metabolism of bile acids in the colon, which in turn have major effects on the lifecycle of C. difficile bacteria. We hypothesized that fecal bile acid composition is altered in patients with recurrent CDI and that FMT results in its normalization. General metabolomics and targeted bile acid analyses were performed on fecal extracts from patients with recurrent CDI treated with FMT and their donors. In addition, 16S rRNA gene sequencing was used to determine the bacterial composition of pre- and post-FMT fecal samples. Taxonomic bacterial composition of fecal samples from FMT recipients showed rapid change and became similar to the donor after the procedure. Pre-FMT fecal samples contained high concentrations of primary bile acids and bile salts, while secondary bile acids were nearly undetectable. In contrast, post-FMT fecal samples contained mostly secondary bile acids, as did non-CDI donor samples. Therefore, our analysis showed that FMT resulted in normalization of fecal bacterial community structure and metabolic composition. Importantly, metabolism of bile salts and primary bile acids to secondary bile acids is disrupted in patients with recurrent CDI, and FMT corrects this abnormality. Since individual bile salts and bile acids have pro-germinant and inhibitory activities, the changes suggest that correction of bile acid metabolism is likely a major mechanism by which FMT results in a cure and prevents recurrence of CDI.

scholarly journals Somatostatin Reduces Bile Secretion and Loss of Bile Constituents in Patients with External Biliary Drainage

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 229-233 ◽  
Author(s):  
Helene Bryde Andersen ◽  
Ljiljana Petronijevic ◽  
Birgitte Giese ◽  
Thorkild Mygind ◽  
Flemming Burcharth
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Composition ◽  
Biliary Drainage ◽  
High Performance ◽  
Potent Inhibitor ◽  
Bile Secretion ◽  
External Biliary Drainage ◽  
Bile Acid Secretion ◽  
Somatostatin 14

The effect of 24-hours continuous somatostatin 14 infusion on the volume of the bile secretion and on the bile composition were studied in seven patients with malignant biliary obstruction who had transhepatic external biliary drainage.The bile acid composition was measured with high performance liquid chromatography (HPLC). Somatostatin infusion significantly reduced the daily bile loss from median 473 ml to 140 ml (41 percent, p=0.01) with a concomitant significant reduction in the daily molar loss of cholesterol, triglyceride, Na+, K+, CI−, Ca++ and Mg++. The loss of chloride and sodium was reduced with median 50 mmol/day each (p=0.01). The relative concentrations of the measured bile constituents did not change significantly, except for bile acids (p=0.02): the concentration of glycochenodeoxycholic acid increased significantly (p=0.04). The molar loss of taurocholic acid decreased significantly (p=0.035), so the increased concentration of glycochenodeoxycholic acid resulted only in a marginally significant reduction in the total molar loss of bile acids (p=0.051).Somatostatin is a potent inhibitor of bile secretion. The peptide may be used in severely bile depleted patients for reducing their serious electrolyte and acidity problems. Analysis of bile acid composition by HPLC is well suited for further investigations of the regulatory mechanisms of bile acid secretion.

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