scholarly journals Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition?

2012 ◽  
Vol 54 (2) ◽  
pp. 307-309 ◽  
Author(s):  
Silje Skrede ◽  
Vidar Martin Steen ◽  
Johan Fernø
Keyword(s):  
Lipid Biosynthesis ◽  
Biosynthesis Activation

scholarly journals The Acetate Pathway Supports Flavonoid and Lipid Biosynthesis in Arabidopsis

2019 ◽  
Vol 182 (2) ◽  
pp. 857-869 ◽  
Author(s):  
Leonardo Perez de Souza ◽  
Karolina Garbowicz ◽  
Yariv Brotman ◽  
Takayuki Tohge ◽  
Alisdair R Fernie
Keyword(s):  
Lipid Biosynthesis

scholarly journals A novel pathway for lipid biosynthesis: the direct acylation of glycerol

2001 ◽  
Vol 42 (12) ◽  
pp. 1979-1986
Author(s):  
Douglas P. Lee ◽  
Andrew S. Deonarine ◽  
Martin Kienetz ◽  
Quansheng Zhu ◽  
Monika Skrzypczak ◽  
...  
Keyword(s):  
Lipid Biosynthesis ◽  
Direct Acylation

scholarly journals Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in Aspergillus nidulans

2021 ◽  
Vol 7 (7) ◽  
pp. 514
Author(s):  
Mariangela Dionysopoulou ◽  
George Diallinas
Keyword(s):  
Plasma Membrane ◽  
Subcellular Localization ◽  
Aspergillus Nidulans ◽  
Membrane Lipids ◽  
Membrane Lipid ◽  
Lipid Biosynthesis ◽  
Transport Kinetics ◽  
Negative Effect ◽  
And Function

Recent biochemical and biophysical evidence have established that membrane lipids, namely phospholipids, sphingolipids and sterols, are critical for the function of eukaryotic plasma membrane transporters. Here, we study the effect of selected membrane lipid biosynthesis mutations and of the ergosterol-related antifungal itraconazole on the subcellular localization, stability and transport kinetics of two well-studied purine transporters, UapA and AzgA, in Aspergillus nidulans. We show that genetic reduction in biosynthesis of ergosterol, sphingolipids or phosphoinositides arrest A. nidulans growth after germling formation, but solely blocks in early steps of ergosterol (Erg11) or sphingolipid (BasA) synthesis have a negative effect on plasma membrane (PM) localization and stability of transporters before growth arrest. Surprisingly, the fraction of UapA or AzgA that reaches the PM in lipid biosynthesis mutants is shown to conserve normal apparent transport kinetics. We further show that turnover of UapA, which is the transporter mostly sensitive to membrane lipid content modification, occurs during its trafficking and by enhanced endocytosis, and is partly dependent on autophagy and Hect-type HulARsp5 ubiquitination. Our results point out that the role of specific membrane lipids on transporter biogenesis and function in vivo is complex, combinatorial and transporter-dependent.

scholarly journals Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

2020 ◽  
Vol 122 (6) ◽  
pp. 895-903 ◽  
Author(s):  
Mounia Beloueche-Babari ◽  
Teresa Casals Galobart ◽  
Teresa Delgado-Goni ◽  
Slawomir Wantuch ◽  
Harold G. Parkes ◽  
...  
Keyword(s):  
Immune Cell ◽  
Lipid Biosynthesis ◽  
Monocarboxylate Transporter ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Monocarboxylate Transporter 1

Interrelationships between xenobiotic metabolism and lipid biosynthesis

1983 ◽  
Vol 32 (11) ◽  
pp. 1667-1672 ◽  
Author(s):  
John Caldwell ◽  
Mary Varwell Marsh
Keyword(s):  
Xenobiotic Metabolism ◽  
Lipid Biosynthesis
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