scholarly journals An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans

2013 ◽  
Vol 55 (2) ◽  
pp. 319-328 ◽  
Author(s):  
Anthony Oxley ◽  
Philip Berry ◽  
Gordon A. Taylor ◽  
Joseph Cowell ◽  
Michael J. Hall ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Vitamin A ◽  
Isotope Dilution ◽  
Stable Isotope Dilution ◽  
Vitamin A Status ◽  
Β Carotene

scholarly journals An LC-MS/MS method for stable isotope dilution studies of γ-carotene bioefficacy and vitamin A status in humans

2013 ◽  
Vol 72 (OCE4) ◽  
Author(s):  
Anthony Oxley ◽  
Philip Berry ◽  
Joseph Cowell ◽  
Michael Hall ◽  
John Hesketh ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Vitamin A ◽  
Isotope Dilution ◽  
Stable Isotope Dilution ◽  
Vitamin A Status

scholarly journals Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans

2005 ◽  
Vol 8 (6) ◽  
pp. 596-607 ◽  
Author(s):  
Harold C Furr ◽  
Michael H Green ◽  
Marjorie Haskell ◽  
Najat Mokhtar ◽  
Penelope Nestel ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Vitamin A ◽  
Isotope Dilution ◽  
Vitamin A Deficiency ◽  
Public Health Problem ◽  
Provitamin A ◽  
Global Public Health ◽  
Nutritional Values ◽  
Stable Isotope Dilution ◽  
Vitamin A Status

AbstractVitamin A deficiency is a major global public health problem. Among the variety of techniques that are available for assessing human vitamin A status, evaluating the provitamin A nutritional values of foodstuffs and estimating human vitamin A requirements, isotope dilution provides the most accurate estimates. Although the relative expense of isotope dilution restricts its applications, it has an important function as the standard of reference for other techniques. Mathematical modelling plays an indispensable role in the interpretation of isotope dilution data. This review summarises recent applications of stable isotope methodology to determine human vitamin A status, estimate human vitamin A requirements, and calculate the bioconversion and bioefficacy of food carotenoids.

scholarly journals Carotene-rich plant foods ingested with minimal dietary fat enhance the total-body vitamin A pool size in Filipino schoolchildren as assessed by stable-isotope-dilution methodology

2007 ◽  
Vol 85 (4) ◽  
pp. 1041-1049 ◽  
Author(s):  
Judy D Ribaya-Mercado ◽  
Cherry C Maramag ◽  
Lorena W Tengco ◽  
Gregory G Dolnikowski ◽  
Jeffrey B Blumberg ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Vitamin A ◽  
Isotope Dilution ◽  
Dietary Fat ◽  
Pool Size ◽  
Plant Foods ◽  
Stable Isotope Dilution ◽  
Total Body

Vitamin A Value of Plant Food Provitamin A - Evaluated by the Stable Isotope Technologies

2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 25-29 ◽  
Author(s):  
Guangwen Tang
Keyword(s):  
Stable Isotope ◽  
Vitamin A ◽  
Provitamin A ◽  
Animal Origin ◽  
Plant Food ◽  
Plant Foods ◽  
A Value ◽  
Provitamin A Carotenoids ◽  
Β Carotene

Humans need vitamin A and obtain essential vitamin A by conversion of plant foods rich in provitamin A and/or absorption of preformed vitamin A from foods of animal origin. The determination of the vitamin A value of plant foods rich in provitamin A is important but has challenges. The aim of this paper is to review the progress over last 80 years following the discovery on the conversion of β-carotene to vitamin A and the various techniques including stable isotope technologies that have been developed to determine vitamin A values of plant provitamin A (mainly β-carotene). These include applications from using radioactive β-carotene and vitamin A, depletion-repletion with vitamin A and β-carotene, and measuring postprandial chylomicron fractions after feeding a β-carotene rich diet, to using stable isotopes as tracers to follow the absorption and conversion of plant food provitamin A carotenoids (mainly β-carotene) in humans. These approaches have greatly promoted our understanding of the absorption and conversion of β-carotene to vitamin A. Stable isotope labeled plant foods are useful for determining the overall bioavailability of provitamin A carotenoids from specific foods. Locally obtained plant foods can provide vitamin A and prevent deficiency of vitamin A, a remaining worldwide concern.

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