scholarly journals Will the real bile acid sulfotransferase please stand up? Identification ofSult2a8as a major hepatic bile acid sulfonating enzyme in mice

2017 ◽  
Vol 58 (6) ◽  
pp. 1033-1035 ◽  
Author(s):  
Paul A. Dawson ◽  
Kenneth D. R. Setchell
Keyword(s):  
Bile Acid ◽  
Hepatic Bile ◽  
The Real

scholarly journals Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis.

1990 ◽  
Vol 31 (12) ◽  
pp. 2209-2218
Author(s):  
H Oda ◽  
H Yamashita ◽  
K Kosahara ◽  
S Kuroki ◽  
F Nakayama
Keyword(s):  
Bile Acid ◽  
Human Serum ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile

scholarly journals Prostaglandin E2promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4α/cholesterol 7α-hydroxylase pathway in mice

Hepatology ◽  
2016 ◽  
Vol 65 (3) ◽  
pp. 999-1014 ◽  
Author(s):  
Shuai Yan ◽  
Juan Tang ◽  
Yuyao Zhang ◽  
Yuanyang Wang ◽  
Shengkai Zuo ◽  
...  
Keyword(s):  
Bile Acid ◽  
Nuclear Receptor ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Hepatic Bile ◽  
Prostanoid Receptor

Hepatic bile acid handling in primary biliary cirrhosis: Effect of ursodeoxycholic acid

2000 ◽  
Vol 118 (4) ◽  
pp. A901
Author(s):  
Paolo Pazzi ◽  
Raffaella Scagliarini ◽  
Susanna Gamberini ◽  
Napoleone Prandini ◽  
Sergio Gullini ◽  
...  
Keyword(s):  
Bile Acid ◽  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Biliary Cirrhosis ◽  
Hepatic Bile

Increased hepatic bile acid production shapes the gut microbiome after cold induced brown adipose tissue activation

2018 ◽  
Vol 275 ◽  
pp. e15
Author(s):  
A. Worthmann ◽  
C. John ◽  
M.C. Rühlemann ◽  
M. Baguhl ◽  
C. Schlein ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Bile Acid ◽  
Brown Adipose Tissue ◽  
Gut Microbiome ◽  
Acid Production ◽  
Hepatic Bile ◽  
Brown Adipose

Effects of Fasting on Hepatic Bile Acid Clearance

1979 ◽  
Vol 161 (2) ◽  
pp. 123-127 ◽  
Author(s):  
L. R. Engelking ◽  
R. Gronwall
Keyword(s):  
Bile Acid ◽  
Hepatic Bile ◽  
Acid Clearance

Fasting and postprandial hepatic bile flow in unanesthetized opossums

1990 ◽  
Vol 259 (5) ◽  
pp. G745-G752 ◽  
Author(s):  
I. Takahashi ◽  
M. K. Kern ◽  
W. J. Dodds ◽  
W. J. Hogan ◽  
R. D. Layman ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Flow ◽  
Common Duct ◽  
Enterohepatic Circulation ◽  
Phase Iii ◽  
Hepatic Bile ◽  
Bipolar Electrodes ◽  
Motor Complex ◽  
The Common ◽  
The Relationship

In conscious opossums, we evaluated the relationship between hepatic bile flow and the intestinal motor function during fasting as well as after feeding. In six opossums, bipolar electrodes were implanted from the gastric antrum to the terminal ileum. After cholecystectomy, the common duct was ligated, and a catheter was tied into the proximal common duct for collecting hepatic bile. During subsequent studies, hepatic bile flow was measured, and bile was returned to the duodenum through an externalized duodenal catheter. Cyclic increases in bile flow during fasting did not show a close correlate with the duodenal migratory motor complex (MMC) cycle. Rather, bile flow showed peak values [0.11 +/- 0.02 (SE) ml/min] when phase III MMC activity reached the midileum. Hepatic bile flow correlated closely with the amount of bile acid secreted by the liver. When the bile acid pool was depleted by diverting bile from the intestine, hepatic secretion of bile fell to uniformly low values of approximately 0.04 ml/min that did not show cyclic variation. Hepatic bile flow after feeding increased to a maximal value of 0.12 +/- 0.01 ml/min at 90 min. We conclude that increases in hepatic bile flow during fasting and after meals are determined mainly by variations in intestinal motor activity that alter small bowel transit and thereby affect the enterohepatic circulation of bile acids.

Rat hepatic bile acid sulfotransferase: enzyme response to androgens and estrogens

1987 ◽  
Vol 252 (2) ◽  
pp. G276-G280
Author(s):  
R. H. Collins ◽  
L. Lack ◽  
P. G. Killenberg
Keyword(s):  
Monoclonal Antibody ◽  
Bile Acid ◽  
High Performance ◽  
Protein Concentration ◽  
Specific Activity ◽  
Antibody Activity ◽  
Hepatic Bile ◽  
Reactive Protein ◽  
Effect Of Treatment ◽  
Relative Molecular Weight

Rat liver bile sulfotransferase activity can be divided into a fraction that reacts with a monoclonal antibody (PK1B) and another fraction that does not. This work was performed to analyze the known response of hepatic bile acid sulfotransferase activity to androgens and estrogens by determining the effect of treatment on the proportion of bile acid sulfotransferase activity that possessed the epitope for PK1B monoclonal antibody. Activity in treated animals was further characterized by high-performance liquid chromatography (HPLC) analysis following purification by PK1B-immunoadsorption chromatography. The results indicate that estrogens and androgens affect the subset of enzyme activity that has the PK1B epitope more than the population that does not. HPLC demonstrates that increases and decreases in activity that follow treatment with androgens and estrogens are mirrored by the proportion of the PK1B-reactive protein that exhibits a relative molecular weight (Mr) greater than 170,000. Radial immunodiffusion assays of hepatic supernatant using a polyclonal antibody raised against PK1B-reactive bile acid sulfotransferase show that changes in specific activity that follow treatment are the result of changes in enzyme protein concentration.

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