scholarly journals Benzodiazepines and disinhibition: a review

2002 ◽  
Vol 26 (12) ◽  
pp. 460-462 ◽  
Author(s):  
Carol Paton
Keyword(s):  
At Risk ◽  
Neurological Disorders ◽  
Impulse Control ◽  
Antipsychotic Drugs ◽  
Significant Risk ◽  
Clinical Implications ◽  
Control Problems ◽  
Medline Search ◽  
Behavioural Disinhibition ◽  
High Degree

AIMS AND METHODSTo describe and attempt to quantify the incidence of disinhibitory reactions to benzodiazepines and to identify those at risk. Medline search, 1966–January 2002.ResultsThe overall incidence of disinhibitory reactions is small, but those with impulse control problems, neurological disorders, learning disabilities, the under 18s and the over 65s are at significant risk.Clinical ImplicationsIt is important to be aware of the ability of benzodiazepines to cause behavioural disinhibition and to maintain a high degree of vigilance when these drugs are administered to patients known to be at risk. In patients who have experienced behavioural disinhibition with benzodiazepines, antipsychotic drugs should be used to modify behaviour in any future emergencies.

scholarly journals 460. Point-of-Care, In-Home SARS-CoV-2 IgG Antibody Testing to Assess Seroprevalence in At-Risk Health Care Workers

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S297-S297
Author(s):  
Eric G Meissner ◽  
Christine Litwin ◽  
Tricia Crocker ◽  
Elizabeth Mack ◽  
Lauren Card
Keyword(s):  
Health Care ◽  
At Risk ◽  
Health Care Workers ◽  
Medical Center ◽  
Point Of Care ◽  
Academic Medical Center ◽  
Significant Risk ◽  
Documented Infection ◽  
Inconclusive Result ◽  
Care Workers

Abstract Background Health care workers are at significant risk for infection with the novel coronavirus SARS-CoV-2. Methods We utilized a point-of-care, lateral flow SARS-CoV-2 IgG immunoassay (RayBiotech) to conduct a seroprevalence study in a cohort of at-risk health care workers (n=339) and normal-risk controls (n=100) employed at an academic medical center. To minimize exposure risk while conducting the study, consents were performed electronically, tests were mailed and then self-administered at home using finger stick blood, and subjects uploaded a picture of the test result while answering an electronic questionnaire. We also validated the assay using de-identified serum samples from patients with PCR-proven SARS-CoV-2 infection. Results Between April 14th and May 6th 2020, 439 subjects were enrolled. Subjects were 68% female, 93% white, and most were physicians (38%) and nurses (27%). In addition, 37% had at least 1 respiratory symptom in the prior month, 34% had cared for a patient with known SARS-CoV-2 infection, 57% and 23% were worried about exposure at work or in the community, respectively, and 5 reported prior documented SARS-CoV-2 infection. On initial testing, 3 subjects had a positive IgG test, 336 had a negative test, and 87 had an inconclusive result. Of those with an inconclusive result who conducted a repeat test (85%), 96% had a negative result. All 3 positive IgG tests were in subjects reporting prior documented infection. Laboratory validation showed that of those with PCR-proven infection more than 13 days prior, 23/30 were IgG positive (76% sensitivity), whereas 1/26 with a negative prior PCR test were seropositive (95% specificity). Repeat longitudinal serologic testing every 30 days for up to 4 times is currently in progress. Conclusion We conducted a contact-free study in the setting of a pandemic to assess SARS-CoV-2 seroprevalence in an at-risk group of health care workers. The only subjects found to be IgG positive were those with prior documented infection, even though a substantial proportion of subjects reported significant potential occupational or community exposure and symptoms that were potentially compatible with SARS-COV-2 infection. Disclosures All Authors: No reported disclosures

scholarly journals Childhood Reports of Food Neglect and Impulse Control Problems and Violence in Adulthood

2016 ◽  
Vol 13 (4) ◽  
pp. 389 ◽  
Author(s):  
Michael Vaughn ◽  
Christopher Salas-Wright ◽  
Sandra Naeger ◽  
Jin Huang ◽  
Alex Piquero
Keyword(s):  
Impulse Control ◽  
Control Problems

scholarly journals Variation between services in polypharmacy and combined high dose of antipsychotic drugs prescribed for in-patients

2002 ◽  
Vol 26 (11) ◽  
pp. 418-420 ◽  
Author(s):  
Maria Harrington ◽  
Paul Lelliott ◽  
Carol Paton ◽  
Maria Konsolaki ◽  
Tom Sensky ◽  
...  
Keyword(s):  
Mental Health ◽  
Clinical Practice ◽  
Antipsychotic Drugs ◽  
Service Level ◽  
Case Mix ◽  
Clinical Implications ◽  
High Dose ◽  
Prescribing Practice ◽  
Acute Psychiatric Wards ◽  
High Doses

Aims and MethodA 1-day census provided an opportunity to examine the variation between 44 mental health services in the frequency of prescribing high doses and polypharmacy of antipsychotic drugs to in-patients on acute psychiatric wards.ResultsThe proportion of patients prescribed a high dose ranged 0–50% and simultaneous use of more than one antipsychotic drug ranged 12–71%. A number of case-mix variables explained 26% and 40%, respectively, of the variance between services on these two indicators of prescribing practice.Clinical ImplicationsServices with high rates of prescription of high dose or polypharmacy might consider a review of clinical practice and of service-level factors that might affect prescribing.

Overlapping dimensional phenotypes of impulsivity and compulsivity explain co-occurrence of addictive and related behaviors

CNS Spectrums ◽  
2018 ◽  
Vol 24 (04) ◽  
pp. 426-440 ◽  
Author(s):  
Jeggan Tiego ◽  
Sanne Oostermeijer ◽  
Luisa Prochazkova ◽  
Linden Parkes ◽  
Andrew Dawson ◽  
...  
Keyword(s):  
Impulse Control ◽  
Structural Equation ◽  
Bifactor Model ◽  
Self Report ◽  
Equation Modeling ◽  
Control Problems ◽  
Addictive Behaviors ◽  
Obsessive Beliefs ◽  
Obsessive Compulsive ◽  
Amazon's Mechanical Turk

ObjectiveImpulsivity and compulsivity have been implicated as important transdiagnostic dimensional phenotypes with potential relevance to addiction. We aimed to develop a model that conceptualizes these constructs as overlapping dimensional phenotypes and test whether different components of this model explain the co-occurrence of addictive and related behaviors.MethodsA large sample of adults (N = 487) was recruited through Amazon’s Mechanical Turk and completed self-report questionnaires measuring impulsivity, intolerance of uncertainty, obsessive beliefs, and the severity of 6 addictive and related behaviors. Hierarchical clustering was used to organize addictive behaviors into homogenous groups reflecting their co-occurrence. Structural equation modeling was used to evaluate fit of the hypothesized bifactor model of impulsivity and compulsivity and determine the proportion of variance explained in the co-occurrence of addictive and related behaviors by each component of the model.ResultsAddictive and related behaviors clustered into 2 distinct groups: Impulse-Control Problems, consisting of harmful alcohol use, pathological gambling, and compulsive buying, and Obsessive-Compulsive-Related Problems, consisting of obsessive-compulsive symptoms, binge eating, and internet addiction. The hypothesized bifactor model of impulsivity and compulsivity provided the best empirical fit, with 3 uncorrelated factors corresponding to a general Disinhibition dimension, and specific Impulsivity and Compulsivity dimensions. These dimensional phenotypes uniquely and additively explained 39.9% and 68.7% of the total variance in Impulse-Control Problems and Obsessive-Compulsive-Related Problems.ConclusionA model of impulsivity and compulsivity that represents these constructs as overlapping dimensional phenotypes has important implications for understanding addictive and related behaviors in terms of shared etiology, comorbidity, and potential transdiagnostic treatments.

scholarly journals Multiple sequence types responsible for healthcare-associated Acinetobacter baumannii dissemination in a single centre in Egypt

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Leena Al-Hassan ◽  
Mai M. Zafer ◽  
Hadir El-Mahallawy
Keyword(s):  
Acinetobacter Baumannii ◽  
Migratory Birds ◽  
Significant Risk ◽  
Carbapenem Resistance ◽  
Healthcare Setting ◽  
Multiple Sequence ◽  
Appropriate Treatment ◽  
Healthcare Associated ◽  
High Degree ◽  
Sequence Types

Abstract Background Acinetobacter baumannii is an increasingly worrying organism in the healthcare setting, due to its multidrug resistance and persistence. Prolonged hospitalisation, immunocompromised patients and excessive antibiotic exposure all contribute to increasing the risk of A. baumannii infections, which makes cancer patients a significant risk group. This study aims to investigate the dissemination of A. baumannii at the National Cancer Institute (NCI) in Cairo – Egypt. Methods All bacterial isolates were typed using Multi-locus Sequence Typing (MLST) to characterise the epidemiology of isolates. The intrinsic OXA-51-like, and the acquired carbapanemases OXA-23, − 24/40, − 58, NDM, IMP, and VIM were also amplified and sequenced to genetically identify mechanisms of carbapenem resistance. Results MLST results show a high degree of multi-clonal dissemination, with 18 different Sequence Types (STs) identified, including 5 novel. The majority of isolates belonged to International Clone (IC) 2, and carbapenem resistance was detected in 93% of isolates and mediated by blaOXA-23, blaOXA-58, blaNDM-1 and blaVIM-1. We also report the presence of a resistant ST732 (OXA-378) which has been previously identified in migratory birds. Conclusions Multiple highly resistant clones were identified in a Cancer hospital in Cairo. It is vital that clinicians and healthcare workers are aware of the population of A. baumannii present in order to have appropriate treatment and infection control practices.

scholarly journals Brief Communication: Newly developing rift in Larsen C Ice Shelf presents significant risk to stability

2015 ◽  
Vol 9 (3) ◽  
pp. 1223-1227 ◽  
Author(s):  
D. Jansen ◽  
A. J. Luckman ◽  
A. Cook ◽  
S. Bevan ◽  
B. Kulessa ◽  
...  
Keyword(s):  
At Risk ◽  
Numerical Model ◽  
Significant Risk ◽  
Suture Zone ◽  
Ice Shelf ◽  
Minimum Area ◽  
Shelf Stability ◽  
Near Future

Abstract. An established rift in the Larsen C Ice Shelf, formerly constrained by a suture zone containing marine ice, grew rapidly during 2014 and is likely in the near future to generate the largest calving event since the 1980s and result in a new minimum area for the ice shelf. Here we investigate the recent development of the rift, quantify the projected calving event and, using a numerical model, assess its likely impact on ice shelf stability. We find that the ice front is at risk of becoming unstable when the anticipated calving event occurs.

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