Clozapine-induced nocturnal enuresis: diagnostic and treatment issues
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Aims and MethodTo report the management of three cases of clozapine-induced enuresis, by description of these cases and literature review.ResultsHeavy sedation, generalised epilepsy and diabetes mellitus induced by clozapine are some of the mechanisms that underlie the emergence of this side-effect.Clinical ImplicationsThese cases illustrate several different pathophysiological mechanisms necessitating further diagnostic investigations before adequate treatment can be started. Clozapine-induced enuresis is probably under-reported owing to the embarrassing nature of this side-effect.