scholarly journals A repeat audit of the Cognitive Analytic Therapy Clinic at Guy's Hospital

1997 ◽  
Vol 21 (3) ◽  
pp. 165-168 ◽  
Author(s):  
Mark Dunn ◽  
Katya Golynkina ◽  
Anthony Ryle ◽  
J. P. Watson
Keyword(s):  
Drop Out ◽  
Drop Out Rate ◽  
Training And Supervision ◽  
Analytic Therapy ◽  
Cognitive Analytic Therapy ◽  
Therapy Clinic

A repeat audit of referrals to the CAT Clinic of Guy's Hospital is reported. Changes in training and supervision of therapists instituted since earlier audits are believed to have contributed to a lower drop-out rate and a higher attendance for follow-up. Mean score reductions on three questionnaires are significant and consistent in the three cohorts. Some characteristics of samples of patients who dropped out and failed to attend for follow up are described.

scholarly journals Interruzione del trattamento nei pazienti con schizofrenia che ricevono olanzapina o aripiprazolo: metanalisi degli studi clinici controllati

2005 ◽  
Vol 6 (1) ◽  
pp. 69-76
Author(s):  
Benedetta Santarlasci ◽  
Giovanni Biricolti ◽  
Cecilia Orsi
Keyword(s):  
Treatment Group ◽  
Literature Search ◽  
Drop Out ◽  
Inclusion Criteria ◽  
Antipsychotic Therapy ◽  
Therapy Discontinuation ◽  
Randomized Controlled ◽  
Drop Out Rate ◽  
Number Of Patients

BACKGROUND: In schizophrenia the drop-out rate can be used as proxy of effectiveness. The drop-out evaluation is also important considering the relevant economic impact for NHS of an antipsychotic therapy discontinuation in terms of patient hospitalization and other related healthcare resources consumption. OBJECTIVE: To analyze the differences in the rates of drop-out from clinical trials between olanzapine and aripiprazole. METHODS: Literature search was based on MEDLINE, on Iowa-IDIS and Drugdex databases (1966-Dec 2004). Analysis included 12 randomized controlled trials (3.778 patients), 8 for olanzapine (2.559 patients) and 4 for aripiprazole (1.219 patients). RCT inclusion criteria were: a) Patients affected by schizophrenia; b) Randomized assignment to olanzapine or aripiprazole treatment group; c) Number of patients included in the treatment group higher than 100; d) Drop-out frequency evaluation between 4th and 26th weeks of follow-up. RESULTS: The rate of treatment discontinuation was greater for aripiprazole than for olanzapine (42,2% vs. 31,6% respectively). The comparison between drop-out percentages is statistically significant (p

Life After Capo

1983 ◽  
Vol 3 (3_suppl) ◽  
pp. 51-53
Author(s):  
Clair C. Williams
Keyword(s):  
Peritoneal Dialysis ◽  
Treatment Options ◽  
Drop Out ◽  
Advanced Age ◽  
Dialysis Modality ◽  
Short History ◽  
Drop Out Rate ◽  
Stage Renal Disease ◽  
End Stage

Of 508 patients trained for CAPD during the first five years, 115 (22.6%) were transferred to an alternative dialysis modality. Of these 87% were transferred to centre dialysis programs, equally divided between hemodialysis and intermittent peritoneal dialysis. Advanced age favoured transfer to intermittent peritoneal dialysis and failure due to peritonitis, transfer to hemodialysis. Three year survival after transfer from CAPD was 38%. The presence of diabetes and advanced age adversely affected survival after transfer. Dialysis modality and peritonitis as the cause of CAPD failure did not affect survival. Other treatment options are available to patients who fail CAPD. A relatively high drop-out is therefore acceptable and preferable to continuing CAPD in patients encountering complications which might ultimately influence their survival. Since its introduction in Toronto in 1977, continuous ambulatory peritoneal dialysis (CAPD) has achieved increasing prominence in the management of end-stage renal disease. Throughout its comparatively short history, one of the major criticisms of this technique has been the relatively high drop-out rate. This report provides a follow-up of patients transferred from CAPD to alternative dialysis modalities.

Oesophageal Probe Evaluation in Radiofrequency Ablation of Atrial Fibrillation (OPERA): results from a prospective randomized trial

EP Europace ◽  
2020 ◽  
Vol 22 (10) ◽  
pp. 1487-1494 ◽  
Author(s):  
Katharina Schoene ◽  
Arash Arya ◽  
Friederike Grashoff ◽  
Helge Knopp ◽  
Alexander Weber ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Radiofrequency Ablation ◽  
Energy Levels ◽  
Randomized Study ◽  
Posterior Wall ◽  
Drop Out ◽  
Peak Temperature ◽  
Drop Out Rate ◽  
Higher Power

Abstract Aims The aim of the study was to determine the incidence of oesophageal lesions after radiofrequency ablation (RFA) of atrial fibrillation (AF) with or without the use of oesophageal temperature probes. Methods and results Two hundred patients were prospectively randomized into two groups: the OPERA+ group underwent RFA using oesophageal probes (SensiTherm™); the OPERA− group received RFA using fixed energy levels of 25 W at the posterior wall without an oesophageal probe. All patients underwent post-interventional endoscopy and Holter-electrocardiogram after 6 months. (Clinical.Trials.gov: NCT03246594). One hundred patients were randomized in OPERA+ and 100 patients in OPERA−. The drop-out rate was 10%. In total, 18/180 (10%) patients developed endoscopically diagnosed oesophageal lesions (EDEL). There was no difference between the groups with 10/90 (11%) EDEL in OPERA+ vs. 8/90 (9%) in OPERA− (P = 0.62). Despite the higher power delivered at the posterior wall in OPERA+ [28 ± 4 vs. 25 ± 2 W (P = 0.001)], the average EDEL size was equal [5.7 ± 2.6 vs. 4.5 ± 1.7 mm (P = 0.38)]. The peak temperature did not correlate with EDEL size. During follow-up, no patient died. Only one patient in OPERA− required a specific therapy for treatment of the lesion. Cumulative AF recurrence after 6 (3–13) months was 28/87 (32%) vs. 34/88 (39%), P = 0.541. Conclusion This first randomized study demonstrates that intraoesophageal temperature monitoring using the SensiTherm™ probe does not affect the probability of developing EDEL. The peak temperature measured by the thermoprobe seems not to correlate with the incidence of EDEL. Empiric energy reduction at the posterior wall did not affect the efficacy of the procedure.

Psychosomatic Inpatient Treatment Achieves in the Medium Term Sustainable Clinical Improvement as well as a Reduction in Utilization of Medical Services-Results of a one-year follow-up

2017 ◽  
Vol 41 (S1) ◽  
pp. s784-s784
Author(s):  
J. Valdes-Stauber ◽  
S. Merath ◽  
S. Krämer
Keyword(s):  
Drop Out ◽  
Medical Services ◽  
Medium Term ◽  
Post Discharge ◽  
Doctor Visits ◽  
Drop Out Rate ◽  
One Year ◽  
Hospital Days

BackgroundThe research on sustainability of effectiveness of inpatient psychosomatic treatment is necessary for epidemiological and economic reasons as well as towards their legitimacy.Objectives and aimsTo investigate whether the achieved clinical improvement by the inpatient treatment continues one year after discharge and whether the utilization of medical services display a significant reduction post-discharge compared to the year before admission.MethodsNaturalistic 1 year follow-up study of a cohort (n = 122). Three measuring time points: T1 (discharge), T2 (6 months after discharge; drop-out rate about 33%), T3 (12 months after discharge; drop-out rate about 49%). Assessment by means of standardized tests of changes in clinical variables, self-efficacy, quality of life, and personality between discharge and one year after discharge. Utilization variables (hospital days, days of incapacity, medication and doctor visits) were compared with ranges in the year before admission.ResultsImprovements at discharge in general functionality, psychological and somatic stress, depressiveness, bitterness level, quality of life and self-efficacy remain one year after discharge sustainably. Furthermore, hospital days, days of incapacity, number of doctor visits and of prescribed drugs decreased significantly in comparison with the year prior to admission.ConclusionsInpatient psychotherapy is effective not only in short-term but also in medium-term. One year after discharge clinically improvement at discharge time-point remains stable and the utilization of medical services decreased significantly. Longer periods of observation, identification of risk groups and of resilient prognostic factors, as well as ensuring post-discharge care are necessary in order to prevent relapses and to made early interventions.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Re-Examining the Role of Interscholastic Sport Participation in Education

2004 ◽  
Vol 94 (3_suppl) ◽  
pp. 1447-1454 ◽  
Author(s):  
Zenong Yin ◽  
Justin B. Moore
Keyword(s):  
Locus Of Control ◽  
Sport Participation ◽  
Sports Participation ◽  
Drop Out ◽  
Self Concept ◽  
Cognitive Test ◽  
Interscholastic Sport ◽  
Drop Out Rate

The purpose of the present study was to examine the relationships of interscholastic sports participation with locus of control, self-concept, cognitive test scores, and school dropout in adolescents via a secondary analysis of National Educational Longitudinal Study 1988 (NELS:88). Subjects were 1,883 students who completed all measurements in 8th grade (1988), at Follow-up 1 (10th, 1990), and Follow-up 2 (12th, 1992). Scales utilized to measure locus of control, self-concept, and cognitive ability were developed by the National Center for Educational Statistics. Dropout was assessed through school records and contact with participants. At baseline and Follow-up 1, students self-reporting sport participation displayed higher self-concept and locus of control; however, these differences were no longer observed at Follow-up 2. Drop-out rate for boys at Follow-up 2 was significantly lower for students reporting interscholastic sport participation at baseline or at Follow-up 1. Similarly, drop-out rate for girls at Follow-up 2 was significantly lower for students reporting interscholastic sport participation at baseline or at Follow-up 1. These findings support the presumed positive role of sport participation for adolescents in American schools.

On the Value of Nonremovable Reminders for Behavior Modification

2011 ◽  
Vol 35 (6) ◽  
pp. 511-530 ◽  
Author(s):  
Gilly Koritzky ◽  
Eldad Yechiam
Keyword(s):  
Behavior Modification ◽  
Target Population ◽  
Drop Out ◽  
Behavioral Modification ◽  
Nail Biting ◽  
Drop Out Rate ◽  
Modification Method ◽  
Modification Technique ◽  
Novel Behavior

The authors examined the effectiveness of a novel behavior modification method for dysfunctional and impulsive habits, based on nonremovable reminders (NrRs). NrRs were implemented by having participants wear nonremovable wristbands designated to constantly remind them of their resolution to quit the targeted habit (nail-biting). Participants were 80 nail-biters who resolved to quit. The NrR approach was contrasted with an aversion-based behavioral modification technique. Recovery was assessed after 3 and 6 weeks of treatment and in a 5-month follow-up. The NrR method was associated with lower drop-out rate and was as successful as the aversion-based method altogether. When considering only non-dropouts, the aversion-based method was more effective. This suggests that the use of constantly present reminders broadens the target population that can benefit from reminders in the course of behavior modification.

Agoraphobia: An Outreach Treatment Programme

2012 ◽  
Vol 41 (3) ◽  
pp. 359-364 ◽  
Author(s):  
Alison Croft ◽  
Ann Hackmann
Keyword(s):  
Effective Treatment ◽  
Drop Out ◽  
Effect Sizes ◽  
Treatment Programme ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Drop Out Rate ◽  
Training And Supervision ◽  
Psychology Service

Background: Agoraphobia is disabling and clients find it hard to access effective treatment. Aims: This paper describes the development of an inexpensive service, delivered by trained volunteers in or near the client's own home. Method: We describe the development of the service, including selection, training and supervision. Outcomes were evaluated over 5 years, and compared with those available from the local psychology service. Results: Effect sizes on all measures were high. Benchmarking indicated that results on comparable measures were not significantly different from the local psychology service. As in many previous studies drop-out rate was fairly high. Conclusions: This model worked well, and was inexpensive and effective. Further research on long term outcome and methods of enhancing engagement is needed.

Fresh Symptom Emergence After Intensive Behaviour Therapy

1976 ◽  
Vol 129 (4) ◽  
pp. 378-383 ◽  
Author(s):  
R. Julian Hafner
Keyword(s):  
Symptomatic Treatment ◽  
Drop Out ◽  
Treatment Programme ◽  
Behaviour Therapy ◽  
Personal Adjustment ◽  
Drop Out Rate ◽  
Wide Range ◽  
One Year

SummaryThe outcome of a standard four-day intensive symptomatic treatment programme with 39 agoraphobics is examined in relation to the incidence of fresh symptom emergence. Twenty-six patients suffered fresh symptom emergence during follow-up, and there was a significant association of fresh symptom emergence with poorer outcome at one-year follow-up. About 18 per cent of patients were adversely affected by the treatment programme, as judged on a wide range of symptoms and measures of inter- and intra-personal adjustment. Sixteen individually treated patients are then compared with the 39 group-treated patients and differences in drop-out rate are discussed.

A New Methodology of Assessing Adult Attachment: Exploring its Validity and Clinical Relevance

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
A. Sochos ◽  
S. Smith ◽  
H. Davies ◽  
V. Heidel
Keyword(s):  
Clinical Relevance ◽  
Interpersonal Problems ◽  
Brief Symptom Inventory ◽  
Inventory Of Interpersonal Problems ◽  
Attachment Research ◽  
Analytic Therapy ◽  
Attachment Dimensions ◽  
Cognitive Analytic Therapy ◽  
Preliminary Support

Aims:Attachment research has provided useful concepts towards an interpersonal approach to psychopathology. Although it suggests that psychological processes are defined by three relational dichotomies (self vs. other, relatedness vs. autonomy, and dependent vs. dependent-on positions), it has not yet assessed separately and simultaneously the eight components generated by the intersection of these dichotomies (e.g. self requesting relatedness, self providing relatedness etc). The aim of the present research was to investigate the validity and potential clinical usefulness of such a neglected approach.Methods:In Study 1, thirty Cognitive Analytic Therapy outpatients at Guy's Hospital, London, were interviewed before treatment on their couple relationships and filled out the Brief Symptom Inventory (BSI) and Inventory of Interpersonal Problems (IIP). A content-analytic method was applied to the transcripts. In Study 2, a new attachment questionnaire was completed by 400 undergraduates, along with the BSI and IIP.Results:In Study 1, at a six-month follow-up, BSI scores were predicted by the Self Requests Autonomy [R Sq = .29, F(1,23) = 10.84, p = .003] and the Other Provides Closeness [R Sq = .23, F(1,23) = 9.72, p=.001] attachment dimensions, while IIP scores were predicted by Self Provides Support [R Sq = .11, F(1,23) = 7.87, p=.003]. In Study 2, factor analysis yielded eight components matching the theoretical expectations and correlating with BSI and IIP scores (rs ranging from .18 to.41).Conclusions:The present findings provide some preliminary support for the validity and potential clinical relevance of the method.

A multicenter, phase II study of trastuzumab plus capecitabine and oxaliplatin (XELOX) as first-line chemotherapy for HER2-positive advanced gastric cancer: Update results of efficacy and toxicity.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 102-102 ◽  
Author(s):  
Jifang Gong ◽  
Tianshu Liu ◽  
Qingxia Fan ◽  
Li Bai ◽  
Feng Bi ◽  
...  
Keyword(s):  
Treatment Options ◽  
Drop Out ◽  
Chinese Patients ◽  
Her2 Positive ◽  
Stage Design ◽  
Drop Out Rate ◽  
Hand Foot Syndrome ◽  
Grade 3 ◽  
Clinical Trial Information

102 Background: The ToGA study showed trastuzumab plus chemotherapy prolonged OS in patients with HER2-positive AGC. Result of REAL2 study suggested that oxaliplatin may be as effective as cisplatin but more tolerable. To further improve treatment options, we initiated a study to evaluate the efficacy and safety of trastuzumab plus XELOX in Chinese patients with HER2-positive AGC. Methods: Simon two-stage design with primary endpoint of best confirmed response rate by RECIST 1.0 was applied. The sample size is calculated to be 46, assuming H0=40%, H1=60%, a=0.05, b =0.2. Considering 10% drop-out rate, the total number of subjects was planned to be 51. Patients with previously untreated, HER2-positive (IHC2+/Dual SISH positive, or IHC 3+), histologically confirmed adenocarcinoma of the stomach or gastro-esophageal junction were eligible. Trastuzumab was administered at a loading dose of 8 mg/kg followed by 6 mg/kg infusion every 3 weeks (q3w). Oxaliplatin was administrated as a 130mg/m2 infusion, q3w, up to 6 cycles. Capecitabine was given orally with 2000mg/m2d, d1-14, q3w. Trastuzumab and capecitabine were continued until disease progression or intolerable toxicity. The NCI-CTCAE version 4.0 is used to evaluate safety profiles. Results: 72 patients (362 patients at 13 centers were screened) were HER2 positive, of which 51 patients were enrolled. The majority of patients were HER2 IHC 3+ (38/51). Response was evaluated in 46 patients, one patient achieved CR and thirty-three patients achieved PR. Till June 2013, 29 patients progressed, 14 cases died, showing PFS of 312 days (95%CI:211-360). The most common AEs that are higher than grade 3 were thrombocytopenia (21.6%), neutropenia (13.7%), anemia (7.84%), leucopenia (3.92%), nausea/vomiting (3.92%), hand-foot syndrome (3.92%). 6 patients possess LVEF decrease by ≥10% and one patient discontinued trastuzumab infusion. Conclusions: The addition of trastuzumab to XELOX was well tolerated and the results demonstrated encouraging efficacy. Survival benefit of this regimen needs further follow-up of patients to be concluded. Clinical trial information: NCT01364493.

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