scholarly journals Use of fluoxetine in patients with diabetes mellitus

1995 ◽  
Vol 19 (9) ◽  
pp. 553-554
Author(s):  
Gill Salmon
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Side Effects ◽  
Pharmaceutical Companies ◽  
Important Group ◽  
Patients With Diabetes

Although pharmaceutical companies report side effects that may occur with use of their medications, little data on specific groups of patients that may be at risk of particular side effects is available (Katz et al, 1991). Patients with diabetes mellitus form an important group for psychiatrists since the occurrence of depression is relatively common with this group and guidance on its treatment is lacking.

The At-Risk Foot Concerns Not Only Patients with Diabetes Mellitus

Gerontology ◽  
2008 ◽  
Vol 54 (6) ◽  
pp. 349-353 ◽  
Author(s):  
Zoltan Pataky ◽  
François R. Herrmann ◽  
Delphine Regat ◽  
Hubert Vuagnat
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Patients With Diabetes

P189 Diabetes may confer protection from giant cell arteritis: results from a large inception cohort

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Luke Spray ◽  
Gary Reynolds ◽  
Jonathon Heaney ◽  
Karolyn Houghton ◽  
Ben Hargreaves ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Side Effects ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Protective Factor ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
High Dose ◽  
Co Morbidity

Abstract Background Giant cell arteritis (GCA) is the commonest large-vessel vasculitis. Until recently high dose corticosteroids had been the mainstay of treatment. Significant concern about steroid related co-morbidities have driven interest in developing new treatment strategies, and the potential to reduce costs associated with managing these complications was pivotal in securing funding for tocilizumab. Despite this little is known about the at-risk population, comprising both those diagnosed with GCA and those suspected of GCA, as both groups undergo the same steroid exposure. We therefore sought to determine if patients referred to our GCA fast track pathway (GCA-FTP) were more or less at risk than the general age matched population of developing corticosteroid related side effects. Methods Data from 356 consecutively referred patients to our GCA-FTP between January 1st 2017 and December 31st 2018 were reviewed. Co-morbidity data is routinely collected as part of our GCA-FTP rolling audit. We determined the frequency of pre-existing co-morbidities most often associated with steroid related side effects and compared these with published background prevalence estimates for a similar age group in the UK. Results In general rates of co-morbidities were lower than published estimates in over-70s, as we did not actively pursue their identification beyond what was readily available at referral (Table 1). Interestingly, however, whilst the prevalence of diabetes mellitus in our cohort (n = 356) was comparable to that in the general population (23.6%), it was significantly lower in those diagnosed with GCA (n = 83) at 11% (p = 0.0017). Despite this difference, background rates of cardiovascular and peripheral vascular disease were similar in each group. Conclusion In our cohort, diabetes mellitus seems to be a protective factor against the development of GCA. Similar results were reported in 2015 from a meta-analysis of inception cohorts involving 903 patients with GCA and 1064 controls. The interaction between diabetes and the onset of GCA merits further investigation. Disclosures L. Spray None. G. Reynolds None. J. Heaney None. K. Houghton None. B. Hargreaves None. B. Thompson None. A. Lorenzi None.

scholarly journals METHOD OF TREATMENT AND MAINTENANCE THERAPY OF PROSTHETIC STOMATITIS IN PATIENT WITH DIABETES MELLITUS

2021 ◽  
pp. 82-86
Author(s):  
V.M. Dvornyk ◽  
L.B. Yerys ◽  
O.I. Teslenko ◽  
G.M. Kuz ◽  
I.Yu. Litovchenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Maintenance Therapy ◽  
Oral Mucosa ◽  
Tissue Regeneration ◽  
Systemic Therapy ◽  
Supportive Therapy ◽  
Diabetic Patients ◽  
Dental Practice ◽  
Patients With Diabetes

Relevance. Adaptation to prostheses and their further wearing is often associated with traumatic injuries of the oral mucosa. Mechanical traumas of the oral mucosa with removable laminar dentures, toxic effects of plastic components, the allergic effects of the prosthesis on the oral mucosa and the prosthesis wearer's body as a whole, as well as a stress factor considerably contribute to the occurrence of prosthetic stomatitis. Most often, a removable laminar denture acts as a combined stimulus. The manifestations of diabetic microangiopathies in the oral mucosa enhance the severity of prosthetic stomatitis in individuals with diabetes mellitus. The clinical picture of prosthetic stomatitis also depends on the size and condition of denture supporting area, for instance, atrophy of the edentulous jaws, conditions for anatomical retention of dentures. Therefore, the treatment of stomatitis in patients who wear removable laminar dentures is still a challenging problem in orthopaedic and therapeutic dentistry. Purpose and objective: to investigate available treatment approaches and maintenance therapy for managing prosthetic stomatitis in patients with diabetes mellitus who wear removable acrylic laminar dentures; to offer our newly developed treatment and maintenance therapy of prosthetic stomatitis in diabetic patients. Material and methods. The existing approaches and methods of treatment and maintenance therapy for prosthetic stomatitis in patients with diabetes mellitus were thoroughly investigated with clear focus on their advantages and disadvantages. The available methods to manage the complications caused by laminar denture wearing in patients with diabetes mellitus include topical remedies and oral hygiene products. The treatment of prosthetic stomatitis in patients who wear dentures is often reported as ineffective. Therefore, at present, it is relevant to search for new methods of treating prosthetic stomatitis under diabetes mellitus with the use of agents that boost the body antioxidant protection, stimulate tissue regeneration and epithelialisation. Results. The method we have developed for the treatment of prosthetic stomatitis in individuals with diabetes mellitus includes the application of 2% Thiotriazolin ointment for local treatment, and Thiotriazolin preparation for systemic therapy. Thiotriazoline is a domestic drug of polytropic action. It has membrane-stabilizing, antioxidant and reparative properties. Thiotriazoline stimulates tissue regeneration and epithelialisation processes, somewhat reduces the intensity of the inflammatory process. In dental practice, 2% Thiotriazolin ointment is recommended to treat ulcerative lesions of the oral mucosa and periodontal tissues. Our treatment method includes the following steps: after the denture adjustment and sanitation of the oral cavity done, patients are prescribed to apply 2% Thiotriazolin ointment onto the denture supporting areas, which are the most often traumatized, in particularly, onto the maxillary tubercles, along the transitional fold, in the sublingual, retromolar and retroalveolar spaces, daily for 7-10 days. The patients are also recommended to apply 2% Thiotriazolin ointment onto the inner surface of the prosthesis base. For systemic therapy, “Thiotriazolin” is prescribed to be taken by mouth in a dosage of 1 tablet of 100 mg per day for 30 day course. Supportive therapy involves Quvertin, while Lizak tablets are used for local prophylaxis. Following the oral sanitation, patients are prescribed to Lizak tablets (should be held in the mouth until dissolved slowly) 3-4 times a day for 5-7 day course. As part of a comprehensive supportive therapy, patients are prescribed Quvertin tablets, 1 tablet twice a day 30 minutes before meals (chew the tablet) for 30 day course. Conclusion. The proposed method of the therapy of prosthetic stomatitis in people with diabetes mellitus is quite easy to use, causes no side effects, produces a positive effect on the clinical course of the conditions, and enabled to achieve a stable remission after the disease, and, thus, can be recommended for implementing into dental practice. The described maintenance therapy for diabetic patients with prosthetic stomatitis is clinically effective, has no side effects, and can increase the periods of remission after the disease. This combination therapy can be recommended as an effective treatment option in therapeutic and orthopaedic dentistry.

scholarly journals The Incidence of Antihypertensive Drug-induced Side Effects in Patients with Diabetes Mellitus Type 2 and Hypertension

2014 ◽  
Vol 68 (6) ◽  
pp. 372 ◽  
Author(s):  
Svjetlana LogaZec ◽  
Mensura Asceric ◽  
Natasa LogaAndrijic ◽  
Berina Kapetanovic ◽  
Enver Zerem
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Antihypertensive Drug ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Drug Induced ◽  
Patients With Diabetes

scholarly journals Flavonoid Pada Buah Jengkol (Pithecellobium Lobatum Benth) Sebagai Terapi Alternatif Diabetes Melitus Tipe 2

2020 ◽  
Vol 2 (2) ◽  
pp. 375-382
Author(s):  
Denny Andika Kurniawan
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Vitamin B12 ◽  
Pancreatic Beta Cell ◽  
The United States ◽  
Protective Agent ◽  
High Prevalence ◽  
The World ◽  
Patients With Diabetes ◽  
Diabetes Melitus

Obat antidiabetes oral banyak memberikan efek samping yang tidak diinginkan, salah satunya obat golongan sulfonilurea yang memiliki efek samping hipoglikemik dan toksisitas hematologik,  obat biguanid memiliki efek samping yaitu gangguan pencernaan, asidosis laktat dan menurunnya absorpsi vitamin B12 sedangkan obat akarbose memiliki efek samping  flatulens, diare dan nyeri abdomen. Diabetes Mellitus  adalah salah satu penyakit tidak menular dengan pravelensi yang tinggi di dunia, Indonesia menempati urutan keempat jumlah penderita diabetes terbesar di dunia setelah India, Cina dan Amerika Serikat. Oleh karena itu, banyaknya efek samping yang terdapat dalam obat – obatan Diabetes Melitus serta fakta bahwa Diabetes Melitus memiliki prevalensi yang tinggi khususnya di Indonesia, para ahli mengembangkan sistem pengobatan tradisional untuk terapi Diabetes mellitus yang relatif aman. Salah satu terapi tradisional yang banyak digunakan oleh masyarakat di Indonesia adalah terapi herbal. Saat ini lebih dari 400 jenis tanaman telah digunakan sebagai pengobatan alternatif. Salah satu tanaman herbal yang berkhasiat sebagai antidiabetik tersebut adalah jengkol (Pithecellobium  jiringa). Jengkol dapat dimanfaatkan sebagai bahan obat-obatan dan diketahui secara tradisional dapat mencegah diabetes serta dapat menurunkan gula darah pada penderita diabetes mellitus. Kandungan senyawa kimia aktif pada biji, kulit batang, dan daun jengkol adalah alkaloid, steroid or triterpenoid, glikosida, saponin, flavonoid, dan tannin.Dari beberapa kandungan yang terdapat pada buah jengkol, Flavonoid adalah yang digunakan sebagai agen antidiabetes dengan cara menjadi agen protektif sel beta pankreas serta dapat meningkatkan sensitivitas insulin.  Abstract: Oral antidiabetic drugs many side effects that are not desired, one of the drugs known as sulfonylureas that have side effects hypoglycemic and toxicity hematologic, drug biguanide have side effects, namely indigestion, lactic acidosis and decreased absorption of vitamin B12, while the drug acarbose have side effects flatulence, diarrhea and abdominal pain. Diabetes Mellitus is one of the non-infect diseases with high prevalence in the world, Indonesia is the fourth-largest number of diabetics in the world after India, China and the United States. Therefore, the many side effects of the drug contained in Diabetes Mellitus, and the fact that Diabetes Mellitus has a high prevalence, especially in Indonesia, experts developed a system of traditional medicine for the treatment of diabetes mellitus is relatively safe. One of the traditional therapy that is widely used by people in Indonesia is herbal therapy. Currently, more than 400 species of plants have been used as an alternative treatment. One of the herbs that are useful as antidiabetic djengkol (Pithecellobium jiringa). Djengkol can be used as a medicine and known traditionally to prevent diabetes and can lower blood sugar in patients with diabetes mellitus. The content of the active chemical compounds in the seeds, bark, and leaves jengkol are alkaloids, steroids or triterpenoids, glycosides, saponins, flavonoids, and tannins. From some of the content contained in fruit jengkol, Flavonoids are used as antidiabetic agents to adopt a pancreatic beta cell protective agent and can improve insulin sensitivity.

scholarly journals Aminoglycosides and Kidney Function

2007 ◽  
Vol 26 (4) ◽  
pp. 294-299
Author(s):  
Momčilo Stanić ◽  
Radoslav Mitić ◽  
Milan Jakovljević
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Health Center ◽  
Kidney Function ◽  
Therapeutic Range ◽  
Kinetic Method ◽  
Patients With Diabetes ◽  
Different Doses

Aminoglycosides and Kidney FunctionThe aminoglycosides are bactericide antibiotics with predominant effecting on the Gramm-negative bacteries, then staphylococci and mycobacteria with a small therapeutic range and with expressive ototoxic, nephrotoxic and with rare neurotoxic side effects. In this work the value of creatinine are investigated in serum of patients who are hospitalized in Internal department of the Health Center in Kosovska Mitrovica, before, in the course of and after therapy with the aminoglycosides antibiotics were given in different doses. The creatinine was determined by kinetic method (Jaffe). The significant increasing of creatinine values in serum was recorded with the groups of patients who have got gentamicine 2x120 mg i.m., gentamicine 2x120 mg in combination with furosemide, the gentamicine 2x120 mg with the patients with diabetes mellitus, gentamicine 2x120 mg in the course of 14 days until with the groups who have been getting gentamicine 1x120 mg, gentamicine 2x80 mg and amikacine 2x500 mg were not recorded the significant increased values of creatinine. The determination of creatinine for the sake of the following degree damage of kidney function in the course therapy of the aminoglycosides was very important.

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Sign in / Sign up

Export Citation Format

Share Document