Torulosis of the Central Nervous System

1943 ◽  
Vol 89 (374) ◽  
pp. 42-51 ◽  
Author(s):  
Donald Blair
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Rare Disease ◽  
Mental Hospital ◽  
The United States ◽  
Observation Unit ◽  
The Third ◽  
The World ◽  
The Central Nervous System

In March, 1939. there was admitted under my care at the St. Pancras Hospital Mental Observation Unit a case of torulosis of the nervous system. This is a very rare disease in this country and the present case is only the third recorded in British medical history (Greenfieldet al., 1938; Smith and Crawford, 1930), and the first one to have come under mental hospital supervision. Although such a rarity here, torulosis is more common in the United States, and cases have been reported from nearly every part of the world.

Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015

2019 ◽  
Vol 143 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Haley Gittleman ◽  
Gino Cioffi ◽  
Toni Vecchione-Koval ◽  
Quinn T. Ostrom ◽  
Carol Kruchko ◽  
...  
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
The United States ◽  
Descriptive Epidemiology ◽  
The Central Nervous System

scholarly journals Scientific production on the effects of COVID-19 on the central nervous system: a systematic review

2021 ◽  
Author(s):  
Eluan Joel Rodrigues da Silva ◽  
Cristiano de Bem Torquato de Souza ◽  
Raphael Henrique Chappuis ◽  
Sarah Evelyn Silva Fernandes ◽  
Kleber Fernando Pereira
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Latin American ◽  
Caribbean Literature ◽  
Scientific Production ◽  
System A ◽  
The World ◽  
The Central Nervous System ◽  
Number Of Publications

Background: The presence of COVID-19 in the world has brought changes to our society. The research groups around the world started an analysis of how the SARS-CoV-2 virus interacts pathophysiologically with biological systems. Objectives: Quantify, based on the literature, the scientific production by Institution and country of origin, which related the damage of COVID-19 in the Central Nervous System (CNS). Design and setting: We conducted a literature review. It was use the databases of PubMed, LILACS (Latin American and Caribbean Literature on Health Sciences), SciElo and The Lancet. Results: 91 articles were included. The Institutions with the most publications were: University of California (United States), All India Institute Of Medical Sciences (India) and Qingdao University (China), with May 2020 being the period with the most publications. The most frequent symptoms caused by COVID-19 in the CNS were: Anosmia, Headache, Vomiting, Nausea and Hyposmia. Conclusions: United States, India and China were the countries with an expressive, even small, number of publications relating the effects of COVID-19 on the CNS. The largest number of publications in May 2020 shows that studies were rapidly developed shortly after the disease was raised to the level of a pandemic in March of the same year. The symptomatic effects of the disease show the primary involvement of the respiratory system with effects on the CNS.

scholarly journals The use of 4-Demethyl-4-cholesteryloxypenclomedine [DM-CHOC-PEN] as Therapy in Adolescent and Young Adult (AYA) Subjects with Advanced Malignancies Involving the Central Nervous System (CNS)

2021 ◽  
pp. 31-33
Author(s):  
Morgan LR ◽  
Weiner RS ◽  
Ware ML ◽  
Bhandari M ◽  
Mahmood T ◽  
...  
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Young Adults ◽  
Young Adult ◽  
The United States ◽  
Adolescents And Young Adults ◽  
Adolescent And Young Adult ◽  
Advanced Malignancies ◽  
The Central Nervous System

In 2020 about 89,000 adolescents and young adults (AYA) (ages 15 to 39) were estimated to be diagnosed with cancer in the United States, 23,890 had CNS and spinal nervous system(SNS) involvement—accounting for one twentieth or five percent of the number cancer diagnoses in the United States. The estimated deaths for this group was18,020 deaths in 2020 (1).

THALIDOMIDE AND PHOCOMELIA

PEDIATRICS ◽  
1962 ◽  
Vol 30 (4) ◽  
pp. 654-659
Author(s):  
Helen B. Taussig
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Structural Formula ◽  
The United States ◽  
Fatal Poisoning ◽  
Pharmaceutical Firms ◽  
Trade Name ◽  
The Central Nervous System ◽  
Synthetic Drug

THALIDOMIDE [alpha (N-phthalimido) glutarimide] is a synthetic drug with the structural formula shown in Figure 1. Thalidomide was invented by the firm of Chemie Grünenthal as a sedative, but when tested on animals was found to be ineffective. Chemie Grünenthal was, however, so certain that thalidomide must have some quieting effect on the central nervous system that it was then tested on man for its effect on epilepsy, and promptly reported to be useless as an anti-convulsant but an excellent sedative. By 1957, thalidomide, marketed under the trade-name of Contergan, was widely used as a sedative and for mental patients. It was considered "safe" to keep in the home because an overdose caused a sound sleep but never produced fatal poisoning. Thalidomide was added to other preparations for conditions where sedation would be beneficial, such as headaches (Algosedive, which is aspirin, phenacetin, and thalidomine), migraine, cough, asthma, gastrointestinal disturbances, grippe, arthralgia, and arthritis. A preparation with a small amount of thalidomide was sold as a tranquilizer. The rights to market the drug were sold to a number of foreign pharmaceutical firms, and the drug was exported to many other countries. Thus, to my certain knowledge, more than a dozen preparations have been placed on the market in a minimum of 16 countries, excluding the United States, where it was distributed to over 1,000 physicians for investigation. Table I gives a list of these drugs which the author has been able to check. Evidence is steadily accumulating which indicates that both the number of preparations and the number of countries is far in excess of the above figures.

Epidemiology and Pathophysiology of Epilepsy

2021 ◽  
pp. 719-721
Author(s):  
David B. Burkholder
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
The United States ◽  
System P ◽  
Neurologic Disorders ◽  
Symptomatic Seizures ◽  
The Central Nervous System ◽  
Active Epilepsy ◽  
Acute Symptomatic Seizures

About 10% of people in the United States have 1 seizure in their lifetime; less than 4% have recurrent seizures or epilepsy. Currently, more than 3.4 million people in the United States have active epilepsy, making it one of the most common neurologic disorders. Seizures can develop at any age, but the most common times are during childhood and after age 60 years. The greatest incidence is in elderly patients. Acute symptomatic seizures (also called provoked seizures or reactive seizures) result from new and active insults to the central nervous system.

Educational Entrepreneurs in Tamil Nadu - A Profile

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Siluvai Raja
Keyword(s):  
Higher Education ◽  
United States ◽  
World Bank ◽  
Education System ◽  
Tamil Nadu ◽  
The United States ◽  
Educational Institutions ◽  
Higher Education System ◽  
The Third ◽  
The World

Education has been considered as an indispensable asset of every individual, community and nation today. Indias higher education system is the third largest in the world, after China and the United States (World Bank). Tamil Nadu occupies the first place in terms of possession of higher educational institutions in the private sector in the country with over 46 percent(27) universities, 94 percent(464) professional colleges and 65 percent(383) arts and science colleges(2011). Studies to understand the profile of the entrepreneurs providing higher education either in India or Tamil Nadu were hardly available. This paper attempts to map the demographic profile of the entrepreneurs providing higher education in Arts and Science colleges in Tamil Nadu through an empirical analysis, carried out among 25 entrepreneurs spread across the state. This paper presents a summary of major inferences of the analysis.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

scholarly journals 55 Malignant primary brain and other central nervous system tumours diagnosed in the Canadian population from 2009 to 2013

2018 ◽  
Vol 45 (S3) ◽  
pp. S16-S17
Author(s):  
EV Walker ◽  
F Davis ◽  
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumour ◽  
Age Distribution ◽  
Paediatric Population ◽  
The United States ◽  
Incidence Rates ◽  
Canadian Population ◽  
Cns Tumours

The Canadian Brain Tumour Registry (CBTR) project was established in 2016 with the aim of enhancing infrastructure for surveillance and clinical research to improve health outcomes for brain tumour patients in Canada. We present a national surveillance report on malignant primary brain and central nervous system (CNS) tumours diagnosed in the Canadian population from 2009-2013. Patients were identified through the Canadian Cancer Registry (CCR); an administrative dataset that includes cancer incidence data from all provinces/territories in Canada. Cancer diagnoses are coded using the ICD-O3 system. Tumour types were classified by site and histology using The Central Brain Tumour Registry of the United States definitions. Incidence rates (IR) and 95% confidence intervals (CI) were calculated per 100,000 person-years and standardized to the 2011 census population age-distribution. Overall, 12,115 malignant brain and CNS tumours were diagnosed in the Canadian population from 2009-2013 (IR:8.43;95%CI:8.28,8.58). Of these, 6,845 were diagnosed in males (IR:9.72;95%CI:9.49,9.95) and 5,270 in females (IR:7.20;95%CI:7.00,7.39). The most common histology overall was glioblastoma (IR:4.06;95%CI:3.95,4.16). Among those aged 0-19 years, 1,130 malignant brain and CNS tumours were diagnosed from 2009-2013 (IR:3.36;95%CI:3.16,3.56). Of these, 625 were diagnosed in males (IR:3.32;95%CI:3.34,3.92) and 505 in females (IR:3.08;95%CI:2.81,3.36). The most common histology among the paediatric population was pilocytic astrocytoma (IR:0.73;95%CI:0.64,0.83). The presentation will include: IRs for other histologies, the geographic distribution of cases and a comparison between Canada and the United States.

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