The Circulatory System and Mental Disorder

1937 ◽  
Vol 83 (346) ◽  
pp. 505-508 ◽  
Author(s):  
F. L. Golla
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mental Disorder ◽  
Circulatory System ◽  
Present Moment ◽  
Therapeutic Effects ◽  
Circulatory Disturbance ◽  
The Central Nervous System

Prof. Golla, in introducing the discussion, said: I do not think there is any subject that is of greater importance at the present moment than the physiology and the pathology of the circulation of the central nervous system. I am dealing now with the physiology, with a view to putting a few facts before you which are fairly well authenticated, and pointing out how very little we know at present. I do not intend to speak of the pathological aspect, but I may remind you, in passing, of such things as the therapeutic effects of amytal and of CO2. Again, in the case of epilepsy, whatever one's ultimate view of epilepsy is, we are all agreed that circulatory disturbance plays a very large part.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

scholarly journals Delayed development of specific thyroid hormone-regulated events in transthyretin null mice

2013 ◽  
Vol 304 (1) ◽  
pp. E23-E31 ◽  
Author(s):  
Julie A. Monk ◽  
Natalie A. Sims ◽  
Katarzyna M. Dziegielewska ◽  
Roy E. Weiss ◽  
Robert G. Ramsay ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Thyroid Hormone ◽  
Bone Growth ◽  
Circulatory System ◽  
Goblet Cells ◽  
Wild Type ◽  
The Central Nervous System ◽  
Delayed Growth

Thyroid hormones (THs) are vital for normal postnatal development. Extracellular TH distributor proteins create an intravascular reservoir of THs. Transthyretin (TTR) is a TH distributor protein in the circulatory system and is the only TH distributor protein synthesized in the central nervous system. We investigated the phenotype of TTR null mice during development. Total and free 3′,5′,3,5-tetraiodo-l-thyronine (T4) and free 3′,3,5-triiodo-l-thyronine (T3) in plasma were significantly reduced in 14-day-old (P14) TTR null mice. TTR null mice also displayed a delayed suckling-to-weaning transition, decreased muscle mass, delayed growth, and retarded longitudinal bone growth. In addition, ileums from postnatal day 0 (P0) TTR null mice displayed disordered architecture and contained fewer goblet cells than wild type. Protein concentrations in cerebrospinal fluid from P0 and P14 TTR null mice were higher than in age-matched wild-type mice. In contrast to the current literature based on analyses of adult TTR null mice, our results demonstrate that TTR has an important and nonredundant role in influencing the development of several organs.

The Physiological Pathology of the Anterior Pituitary

1939 ◽  
Vol 85 (357) ◽  
pp. 619-648 ◽  
Author(s):  
Max Reiss
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mental Disorder ◽  
Anterior Pituitary ◽  
Present Knowledge ◽  
Cortical Function ◽  
The Central Nervous System ◽  
The Brain

[In the physiology of the central nervous system, the hypothalamus has of recent years obtained a position of much enhanced importance. There is reason to believe that it has a determining influence on cortical function and evidence is not wanting that some psychotic conditions are associated with hypothalmic disturbance. It may well be that many forms of mental disorder are conditioned by a lesion of the hypothalamus. This close anatomical and physiological relationship between this area of the brain and the pituitary we think, therefore, cannot be over-emphasized. Dr. Max Reiss was asked by the Research Bureau to present a review of our present knowledge of the anterior pituitary, on which he is a recognized authority.]

THE PHARMACOLOGICAL PROPERTIES OF THE INSECTICIDE DIELDRIN

1954 ◽  
Vol 32 (5) ◽  
pp. 498-503 ◽  
Author(s):  
C. W. Gowdey ◽  
A. R. Graham ◽  
J. J. Seguin ◽  
G. W. Stavraky
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circulatory System ◽  
Submaxillary Gland ◽  
Salivary Secretion ◽  
Chorda Tympani ◽  
Vagus Nerves ◽  
Reflex Excitability ◽  
The Central Nervous System ◽  
Stimulation Of

The effects of dieldrin (hexachloro-epoxy-octahydro-dimethanonaphthalene) were studied in acute experiments on cats and rabbits. When injected intravenously or intra-arterially, it caused excitation of the central nervous system, which resulted in increased reflex excitability, convulsions, bradycardia, and some vasodepression. Dieldrin potentiated the effects of acetylcholine on the central nervous system and on the circulatory system as well as on intestinal motility. These latter manifestations were abolished by section of the vagus nerves, indicating a central action. Dieldrin had no effect on salivary secretion produced either by stimulation of the chorda tympani or by injections of acetylcholine in the decentralized submaxillary gland. Thus, although dieldrin has a marked parasympathomimetic action, this effect is exerted through stimulation of central mechanisms and not peripherally.

scholarly journals The influence of occupational environment and professional factors on the risk of cardiovascular disease

Medicina ◽  
2006 ◽  
Vol 43 (2) ◽  
pp. 96 ◽  
Author(s):  
Vytautas Obelenis ◽  
Vilija Malinauskienė
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circulatory System ◽  
Electrolyte Imbalance ◽  
Vascular Lesions ◽  
Cholesterol Concentration ◽  
Long Term Effects ◽  
Arterial Blood ◽  
The Central Nervous System

The article reviews the recent scientific literature and the authors’ studies on this topic. Occupational conditions and psychological factors have been shown to play an important role in the etiopathogenesis of cardiovascular diseases. Their effect is often indirect, through damage to the central nervous, respiratory, and neuroendocrine systems. Hot climate in the workplace and intense infrared radiation cause the water and electrolyte imbalance and chronic hyperthermia and manifests as neurovegetative dystonia. The long-term effects of low temperatures condition ischemic lesions in circulatory system, trophic organ destruction. The influence of ultrahigh-frequency electromagnetic radiation on the cardiovascular system is directly related to the central nervous system and neurohumoral lesions. “Microwave disease” often manifests as polymorphic dystonia. Exposure to occupational vibration causes “white finger” syndrome or Raynaud’s phenomenon together with cerebral vascular lesions. Recent studies have confirmed that noise as a chronic stressor causes the imbalance in the central and vegetative nervous systems and changes in homeostasis. Noise increases catecholamine and cholesterol concentration in blood, has an effect on plasma lipoprotein levels, increases heart rate, arterial blood pressure, and risk of myocardial infarction. Psychophysiological changes caused by long-term stress influence constant pathological changes in the central nervous system, endocrine and cardiovascular systems. The long-term effect of psychogenic stressors is very important in the etiopathogenesis of psychosomatic diseases.

scholarly journals Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System

Antioxidants ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 46 ◽  
Author(s):  
Rafael Franco ◽  
Gemma Navarro ◽  
Eva Martínez-Pinilla
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Circulatory System ◽  
Reducing Power ◽  
Antioxidant Defense System ◽  
Age Related ◽  
The Central Nervous System ◽  
High Level

Differential antioxidant action is found upon comparison of organ/tissue systems in the human body. In erythrocytes (red blood cells), which transport oxygen and carbon dioxide through the circulatory system, the most important issue is to keep hemoglobin in a functional state that requires maintaining the haem group in ferrous (Fe2+) state. Conversion of oxidized Fe3+ back into Fe2+ in hemoglobin needs a special mechanism involving a tripeptide glutathione, glucose-6-phosphate dehydrogenase, and glucose and NADPH as suppliers of reducing power. Fava beans are probably a good resource to make the detox innate system more robust as the pro-oxidant molecules in this food likely induce the upregulation of members of such mechanisms. The central nervous system consumes more oxygen than the majority of human tissues, i.e., 20% of the body’s total oxygen consumption and, therefore, it is exposed to a high level of oxidative stress. This fact, together with the progressive age-related decline in the efficiency of the antioxidant defense system, leads to neuronal death and disease. The innate mechanism operating in the central nervous system is not well known and seems different to that of the erythrocytes. The strategies of antioxidant intervention in brain will be reviewed here.

scholarly journals Prospects for Applying Xenon Curative Properties in Pediatrics

2018 ◽  
Vol 15 (5) ◽  
pp. 390-395
Author(s):  
Tatiana S. Sabinina ◽  
Vladimir G. Bagaev ◽  
Ilia F. Alekseev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Noble Gas ◽  
The Body ◽  
Therapeutic Effects ◽  
Pediatric Practice ◽  
Therapeutic Concentration ◽  
Pain Syndromes ◽  
The Central Nervous System ◽  
The Ideal

The review discusses experimental and clinical trials on applying noble gas Xenon to treat therapeutic conditions in adults, as well as the prospects for its applying in children. Xenon therapeutic effects on the body are based on the healing properties of a noble gas. Xenon is close to the ‘ideal anesthetic’ by its anesthetic properties; but in addition, it possesses organoand neuroprotective as well as anti-stress properties which have been proved in experiment and clinically. Xenon in pediatric practice is an attractive agent because it is non-toxic, effective for the treatment of posthypoxic and traumatic impairments of the central nervous system, pain syndromes and stress conditions at its therapeutic concentration up to 30%.

scholarly journals DYSFUNCTION OF THE AUTONOMIC NERVOUS SYSTEM IN EPILEPSY

2019 ◽  
Vol 72 (1) ◽  
pp. 120-123
Author(s):  
Beata Łabuz-Roszak ◽  
Iwona Mańka-Gaca
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Ion Channels ◽  
Antiepileptic Drugs ◽  
Autonomic Dysfunction ◽  
Circulatory System ◽  
Epileptic Seizures ◽  
Autonomic Nervous ◽  
The Central Nervous System

Generalized or partial epileptic seizures may be accompanied by autonomic dysfunction. They may also take the form of self-inflicted seizures or be present during interictal period. Arrhythmias, resulting in haemodynamic disturbances in the circulatory system and prolonged hypoxia of the central nervous system, may itself provoke secondary episodes of seizure morphology. The doctor when diagnosing patients with epileptic seizures should always be aware of the potential for cardiogenic disorders. Consideration should be given to the effect of epilepsy on the structure of the autonomic nervous system, the effect of antiepileptic drugs, and the potential for mutations within the ion channels.

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