Endocrinopathies and Psychoses

1936 ◽  
Vol 82 (341) ◽  
pp. 773-784 ◽  
Author(s):  
James H. Hutton ◽  
D. L. Steinberg

The problem of the relationship of the endocrine system to personality and its disorders has long been an intriguing one. The literature abounds with the views of the psychiatrist, physiologist, pathologist and endocrinologist, and still there remains a multitude of challenging questions unanswered. The ætiology of personality disorders, that of the psychoses, and the true function of the endocrines and their working mechanism have never been satisfactorily determined. To establish scientifically any ætiological factor in medicine one must make a definite diagnosis of the entity, identify the ætiological factor, the specific pathological picture, and the influence of specific therapy.

2010 ◽  
Vol 108 (1-2) ◽  
pp. 141-145 ◽  
Author(s):  
Attila J. Pulay ◽  
Frederick S. Stinson ◽  
W. June Ruan ◽  
Sharon M. Smith ◽  
Roger P. Pickering ◽  
...  

Psychotherapy ◽  
2009 ◽  
Vol 46 (2) ◽  
pp. 233-248 ◽  
Author(s):  
J. Christopher Muran ◽  
Jeremy D. Safran ◽  
Bernard S. Gorman ◽  
Lisa Wallner Samstag ◽  
Catherine Eubanks-Carter ◽  
...  

Author(s):  
Paul S. Links ◽  
Jamal Y. Ansari ◽  
Fatima Fazalullasha ◽  
Ravi Shah

The purpose of this review is (a) to study and systematically review the recent literature examining the co-occurrence and relationships between Axis I psychiatric disorders and Axis II personality disorders (PDs), specifically the five originally proposed for DSM- 5, and (b) to consider the clinical utility of the current Axis I and II approach in DSM-IV-TR. Community surveys or prospective cohort studies were reviewed as a priority. Our review indicates that the associations between clinical disorders and PDs clearly varied within each disorder and across the five PDs. Our understanding has advanced, particularly related to the clinical utility of comorbidity; however, it seems premature to conclude that comorbidity is best conceptualized by having all disorders in a single category or by deleting disorders so that comorbidity no longer occurs. Our review suggests some priorities for future research into comorbidity such as including PDs in future multivariate comorbidity models.


1989 ◽  
Vol 25 (7) ◽  
pp. A84-A85 ◽  
Author(s):  
Gerald Nestadt ◽  
Alan J. Romanoski ◽  
C.Hendricks Brown ◽  
William W. Eaton ◽  
Marshall F. Folstein ◽  
...  

2009 ◽  
Vol 39 (12) ◽  
pp. 2025-2042 ◽  
Author(s):  
W. T. Carpenter ◽  
J. R. Bustillo ◽  
G. K. Thaker ◽  
J. van Os ◽  
R. F. Krueger ◽  
...  

BackgroundIn an effort to group mental disorders on the basis of etiology, five clusters have been proposed. Here we consider the validity of the cluster comprising selected psychotic and related disorders.MethodA group of diagnostic entities classified under schizophrenia and other psychotic disorders in DSM-IV-TR were assigned to this cluster and the bordering disorders, bipolar (BD) and schizotypal personality disorders (SPD), were included. We then reviewed the literature in relation to 11 validating criteria proposed by the DSM-V Task Force Study Group.ResultsRelevant comparisons on the 11 spectrum criteria are rare for the included disorders except for schizophrenia and the two border conditions, BD and SPD. The core psychosis group is congruent at the level of shared psychotic psychopathology and response to antipsychotic medication. BD and SPD are exceptions in that psychosis is not typical in BD-II disorder and frank psychosis is excluded in SPD. There is modest similarity between schizophrenia and BD relating to risk factors, neural substrates, cognition and endophenotypes, but key differences are noted. There is greater support for a spectrum relationship of SPD and schizophrenia. Antecedent temperament, an important validator for other groupings, has received little empirical study in the various psychotic disorders.ConclusionsThe DSM-IV-TR grouping of psychotic disorders is supported by tradition and shared psychopathology, but few data exist across these diagnoses relating to the 11 spectrum criteria. The case for including BD is modest, and the relationship of BD to other mood disorders is addressed elsewhere. Evidence is stronger for inclusion of SPD, but the relationship with other personality disorders along the 11 criteria is not addressed and the absence of psychosis presents a conceptual problem. There are no data along the 11 spectrum criteria that are decisive for a cluster based on etiology, and inclusion of BD and SPD is questionable.


2009 ◽  
Vol 123 (5) ◽  
pp. 477-481 ◽  
Author(s):  
A K Arya ◽  
H L Beer ◽  
J Benton ◽  
I Lewis-Jones ◽  
A C Swift

AbstractBackground and methods:Young's syndrome describes a combination of male infertility, azoospermia, bronchiectasis and sinusitis. Although Young's syndrome is a well accepted disorder within the realms of infertility medicine, it is also accepted as being a potential cause of sino-nasal disease which is rarely seen by otolaryngologists. However, the significance of the sinus component within this triad is not fully understood. To gain further insight into the relationship of sinusitis with Young's syndrome, we reviewed all of the currently available published literature.Results:Within the reviewed literature, the diagnosis of sinusitis in Young's syndrome was crude and poorly defined; there was little emphasis on sinus disease in most publications.Conclusions:The prevalence of Young's syndrome is reported to be declining, and the level of evidence regarding sinus disease within this syndrome is limited to case series only. There is, in fact, little evidence to support Young's syndrome being a significant aetiological factor for sinus disease, nor indeed to support the existence of Young's syndrome as an entity in its own right. The only documented aetiological factor is mercury exposure in childhood, an event that is seldom currently encountered; this would support our theory of the extinction of the condition. As an incidental finding, we found that the term Young's syndrome refers to two different medical conditions.


1997 ◽  
Vol 200 (5) ◽  
pp. 869-881 ◽  
Author(s):  
J Ewer ◽  
S C Gammie ◽  
J W Truman

A successful ecdysis in insects requires the precise coordination of behaviour with the developmental changes that occur late in a moult. This coordination involves two sets of endocrine cells: the peripherally located Inka cells, which release ecdysis triggering hormone (ETH), and the centrally located neurosecretory neurones, the VM neurones, which release eclosion hormone (EH). These two sets of endocrine cells mutually excite one another: EH acts on the Inka cells to cause the release of ETH. ETH, in turn, acts on the VM neurones to cause the release of EH. This positive-feedback relationship allows the Inka cells and the VM neurones to be the peripheral and central halves, respectively, of a decision-making circuit. Once conditions for both halves have been satisfied, their reciprocal excitation results in a massive EH/ETH surge in the blood as well as a release of EH within the central nervous system. This phasic signal then causes the tonic activation of a distributed network of peptidergic neurones that contain crustacean cardioactive peptide. The relationship of the latter cells to the subsequent maintenance of the ecdysis motor programme is discussed.


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