The Alienist Department of India

1932 ◽  
Vol 78 (321) ◽  
pp. 331-341 ◽  
Author(s):  
W. S. Jagoe Shaw
Keyword(s):  
Mental Disorders ◽  
Small Group ◽  
Mental Disease ◽  
Good Deal ◽  
Present Situation ◽  
Central Hospital ◽  
General Review ◽  
Medical Superintendent ◽  
Senior Officer ◽  
Mental Diseases

In view of the present situation in India, it seems advisable to place on record a short general review of the position of psychiatry there, and of the difficulties that have delayed improvement during the twenty years of my own experience. Having joined the Department in 1906, and having served in it since then, as Medical Superintendent, in succession, of the Punjab Asylum, Lahore, the Burma Asylum, Rangoon, and the Central Hospital for Mental Diseases, Yeravda, Poona (the last since 1912), I feel qualified to criticize it now. From 1912 until my retirement in 1926 I was the Senior Officer of the Department. By the term “Alienist Department of India” I refer to the system of asylums and mental hospitals “established” or “licensed” by the Provincial Governments for the treatment of mental disorders under the Indian Lunacy Act of 1912, and to the small group of specialists who have managed them, both before and since the coming of that Act into force. Only those institutions “established” by Government need be considered, because, as far as I am aware, no private “licensed” hospitals exist. This fact alone indicates the degree of interest that the more educated Indians take in the treatment of mental disease. The Parsis, however, have, in my experience, done a good deal to ameliorate the condition of the insane in Bombay, but this race is a small one, numbering only some 101,000.

Diet as a Factor in the Causation of Mental Disease

1916 ◽  
Vol 62 (258) ◽  
pp. 505-529
Author(s):  
Chas. Mercier
Keyword(s):  
Present State ◽  
Mental Disease ◽  
Good Deal ◽  
New Disease ◽  
Nervous Disease ◽  
General Paralysis ◽  
Dark Ages ◽  
Mental Diseases ◽  
The World ◽  
The Universe

It is just forty years since I first ventured to call in question the accepted doctrines of the causation of nervous diseases. In an article in the British and Foreign Medical and Chirurgical Review, an excellent quarterly now long defunct, I likened the imagination of physicians in this respect to the imagination of that fortunate sailor to whom was granted (nowadays we should say who was given) the fairy privilege of having three wishes fulfilled. After he had secured all the rum in the world and all the tobacco in the world by his first two wishes, he could think of nothing further to desire than “a little more rum.” So physicians, after they had attributed every known nervous disease to sexual excess and syphilis, had no explanation of a new disease to offer beyond a little more sexual excess. The only nervous diseases that were not then attributed partly or wholly to syphilis were tabes and general paralysis. Some five-and-twenty years ago, when an eminent physician was about to lecture upon the causes of insanity, I hazarded the conjecture that we should hear a good deal about masturbation, and I had no reason to repent of my prophecy. We may be pardoned a little natural exultation when we contrast the present state of ætiological doctrine with that which prevailed in those dark ages. We had then no more reason for our belief than Aristotle had for the belief that all heavy bodies tend to the centre of the universe, but now we know that the mental diseases that we used fondly to ascribe to sexual excess and syphilis are, in fact, due to repressed complexes and infantile incestuous longings. How foolish were our predecessors! How enlightened are we!

Nomenclature of Mental Diseases

1903 ◽  
Vol 49 (205) ◽  
pp. 236-245 ◽  
Author(s):  
A. R. Urquhart
Keyword(s):  
Chronic Disease ◽  
Mental Disorders ◽  
Present State ◽  
Royal College ◽  
Mental Disease ◽  
The Other ◽  
Medical Society ◽  
The Third ◽  
Mental Diseases

I have ventured to suggest that we should now consider what we are going to do about the classification of mental disorders. Lately, the Royal College of Physicians of London decided to revise the Nomenclature of Diseases, and publish another edition. The President of this College is on the Committee; as is also Dr. Savage, our colleague in London, who has taken much interest in this question. I was somewhat surprised the other day when I asked for a copy of the Nomenclature of Diseases in the Royal Medical Society of London, to find that they did not have a copy in their library—a book which is supposed to guide the profession in the statistical registration of diseases. In 1896, for the third edition, an attempt was made to reform the nomenclature of mental diseases, under the direction of Dr. Hack Tuke and Dr. Savage. In its present state it is still unsatisfactory. The classification with which we have to deal is as follows:—First, there is “idiocy (cretinism), and then mania (acute or chronic), delirious, hysterical, puerperal, epileptic, traumatic, syphilitic, gouty, from either acute or chronic disease, alcoholic, plumbic, or other poisons.” Acute is an absurd word, because we specially want to mark the duration. Acute should be rendered Recent. Then there is “melancholia (acute or chronic), delirious, hypochondriac, climacteric, puerperal, epileptic, syphilitic, acute, other diseases.” Then there is “dementia (primary or secondary), senile, climacteric, puerperal, epileptic, traumatic, syphilitic, acute, other diseases.” Then there is “mental stupor, anergic, delusional.” Then there is “general paralysis.” That is not a mental disease. Lastly, there is “delusional insanity.”

scholarly journals Parental mental illness and their offspring’s mental health in Rwanda: neuropsychiatric hospital of Rwanda

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Donat Rusengamihigo ◽  
Jean Mutabaruka ◽  
Emmanuel Biracyaza ◽  
Olga Magalakaki ◽  
Mayssa El’Husseini
Keyword(s):  
Mental Health ◽  
Mental Illness ◽  
Mental Disorders ◽  
Mental Disease ◽  
Psychological Problems ◽  
Stress Disorders ◽  
Control Group ◽  
Case Group ◽  
Depression Symptoms ◽  
Mental Diseases

Abstract Background Offspring of the parents with mental disorders are at higher risk to have the mental diseases throughout the world. This study examined the association between psychopathology of parents and the mental health of their offspring in Neuropsychiatric Hospital of Rwanda, Butare Branch. Methods A cross-sectional study made up of case and control offspring was conducted on the case group made up of 80 offspring born to parents with mental diseases and a control group of 80 offspring from parents without mental disease. Hamilton Rating Scale for Depression (HRSD, α = 0.82), Posttraumatic stress disorders scale (PTSD, α = 0.73) and the Test of Psychological Problems (TPP, α = 0.93) were used. STATISTICA version 8 was used for statistical analysis. Results Results indicated a significance difference between the two groups on depressive symptoms, psychological problems and PTSD symptomatology. The case group seemed to experience high level symptoms than the control group. Results indicated that, among the offspring born to parents with mental disease, there was a significant correlation between anxiety and depression symptoms (r = 0.71, p < .001), PTSD and eating disorder (r = 0.75, p < .001), domestic violence and PTSD (r = 0.78, p < .001), aggressive behavior and PTSD (r = 0.79, p < .001), somatoform disorders and PTSD (r = 0.98, p < .001). No significant association between the low self-esteem, depression, anxiety, mental disorders induced drug abuse and PTSD was found. Conclusion Offspring of the parents with mental disorders had higher risk to develop mental diseases than the offspring born to the parents without mental diseases. Taking into account the assessment of parents’ mental illness when taking care of the offspring’s psychological disorders is needed in the neuropsychiatric hospital.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

2020 ◽  
Vol 26 ◽  
Author(s):  
Miquel Martorell ◽  
Xavier Lucas ◽  
Pedro Alarcón-Zapata ◽  
Xavier Capó ◽  
Maria Magdalena Quetglas-Llabrés ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Small Molecules ◽  
Xanthine Oxidase ◽  
Cell Damage ◽  
Bipolar Affective Disorder ◽  
Oxidative Reaction ◽  
Mental Diseases ◽  
Potential Therapeutic Application ◽  
Increased Activity ◽  
Dietary Flavonoids

: Mental disorders comprise diverse human pathologies including depression, bipolar affective disorder, schizophrenia, and dementia that affect millions of people around the world. The causes of mental disorders are unclear but growing evidence suggests that oxidative stress and the purine/adenosine system play a key role in their development and progression. Xanthine oxidase (XO) is a flavoprotein enzyme essential for the catalysis of the oxidative hydroxylation of purines -hypoxanthine and xanthine- to generate uric acid. As a consequence of the oxidative reaction of XO, reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are produced and, further, contribute to the pathogenesis of mental disorders. Altered XO activity has been associated with free radical-mediated neurotoxicity inducing cell damage and inflammation. Diverse studies reported a direct association between an increased activity of XO and diverse mental diseases including depression or schizophrenia. Small-molecule inhibitors, such as the well-known allopurinol, and dietary flavonoids, can modulate the XO activity and subsequent ROS production. In the present work, we review the available literature on XO inhibition by small molecules and their potential therapeutic application in mental disorders. In addition, we discuss the chemistry and molecular mechanism of XO inhibitors, as well as the use of structure-based and computational methods to design specific inhibitors with the capability of modulating XO activity.

scholarly journals Examining the impact of mental disease on type 2 diabetes outcomes: results from the EpiChron Cohort

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
I Guerrero Fernández de Alba ◽  
A Gimeno-Miguel ◽  
B Poblador Plou ◽  
K Bliek Bueno ◽  
J Carmona Pirez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Substance Abuse ◽  
Early Detection ◽  
Health Outcomes ◽  
Emergency Room ◽  
Mental Disease ◽  
Emergency Room Visits ◽  
Mental Diseases ◽  
The Impact

Abstract Background Type 2 diabetes mellitus (T2D) is often accompanied by other chronic diseases, including mental diseases (MD). This work aimed at studying MD prevalence in T2D patients and analyse its impact on T2D health outcomes. Methods Retrospective, observational study of individuals of the EpiChron Cohort aged 18 and over with prevalent T2D at baseline (2011) in Aragón, Spain (n = 63,365). Participants were categorized by the existence or absence of MD, defined as the presence of depression, anxiety, schizophrenia or substance abuse. MD prevalence was calculated, and a logistic regression model was performed to analyse the likelihood of the four studied health outcomes (4-year all-cause mortality, all-cause hospitalization, T2D-hospitalization, and emergency room visits) based on the presence of each type of MD, after adjusting by age, sex and number of comorbidities. Results Mental diseases were observed in 19% of T2D patients, with depression being the most frequent condition, especially in women (20.7% vs. 7.57%). Mortality risk was significantly higher in patients with MD (odds ratio -OR- 1.24; 95% confidence interval -CI- 1.16-1.31), especially in those with substance abuse (OR 2.18; 95% CI 1.84-2.57) and schizophrenia (OR 1.82; 95% CI 1.50-2.21). The presence of MD also increased the risk of T2D-hospitalization (OR 1.51; 95% CI 1.18-1.93), emergency room visits (OR 1.26; 95% CI 1.21-1.32) and all-cause hospitalization (OR 1.16; 95% CI 1.10-1.23). Conclusions The high prevalence of MD among T2D patients, and its association with health outcomes, underscores the importance of providing integrated, person-centred care and early detection of comorbid mental diseases in T2D patients to improve disease management and health outcomes. Key messages Comprehensive care of T2D should include specific strategies for prevention, early detection, and management of comorbidities, especially mental disorders, in order to reduce their impact on health. Substance abuse was the mental disease with the highest risk of T2D-hospitalization, emergency room visits and all-cause hospitalization.

Mental Diseases in Peking Between 1933 and 1943

1960 ◽  
Vol 106 (442) ◽  
pp. 274-280 ◽  
Author(s):  
Liang-Wei Chu ◽  
Mei-Chen Liu
Keyword(s):  
Mental Disorders ◽  
Relative Frequency ◽  
Medical Profession ◽  
Chinese Patients ◽  
Mental Diseases

This report is based on a survey of 1,716 Chinese patients admitted to the Peking Municipal Psychopathic Hospital during the years 1933–1943. It is mainly concerned with a statistical presentation of the relative frequency of the various mental disorders and with certain other data which may be of interest to psychiatrists and other members of the medical profession.

Сellular and Molecular Mechanisms of Proinflammatory Monocytes Participation in the Pathogenesis of Mental Disorders. Part 3

Psychiatry ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 125-134
Author(s):  
E. F. Vasilyeva ◽  
O. S. Brusov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mental Disorders ◽  
Molecular Mechanisms ◽  
Microglial Cells ◽  
Inflammatory Reactions ◽  
Mental Diseases ◽  
The Central Nervous System ◽  
The Brain

Background: at present, the important role of the monocyte-macrophage link of immunity in the pathogenesis of mental diseases has been determined. In the first and second parts of our review, the cellular and molecular mechanisms of activation of monocytes/macrophages, which secreting proinflammatory CD16 receptors, cytokines, chemokines and receptors to them, in the development of systemic immune inflammation in the pathogenesis of somatic diseases and mental disorders, including schizophrenia, bipolar affective disorder (BAD) and depression were analyzed. The association of high levels of proinflammatory activity of monocytes/macrophages in patients with mental disorders with somatic comorbidity, including immune system diseases, is shown. It is known that proinflammatory monocytes of peripheral blood, as a result of violation of the integrity of the hematoencephalic barrier can migrate to the central nervous system and activate the resident brain cells — microglia, causing its activation. Activation of microglia can lead to the development of neuroinammation and neurodegenerative processes in the brain and, as a result, to cognitive disorders. The aim of review: to analyze the results of the main scientific studies concerning the role of cellular and molecular mechanisms of peripheral blood monocytes interaction with microglial cells and platelets in the development of neuroinflammation in the pathogenesis of mental disorders, including Alzheimer’s disease (AD). Material and methods: keywords “mental disorders, AD, proinflammatory monocytes, microglia, neuroinflammation, cytokines, chemokines, cell adhesion molecules, platelets, microvesicles” were used to search for articles of domestic and foreign authors published over the past 30 years in the databases PubMed, eLibrary, Science Direct and EMBASE. Conclusion: this review analyzes the results of studies which show that monocytes/macrophages and microglia have similar gene expression profiles in schizophrenia, BAD, depression, and AD and also perform similar functions: phagocytosis and inflammatory responses. Monocytes recruited to the central nervous system stimulate the increased production of proinflammatory cytokines IL-1, IL-6, tumor necrosis factor alpha (TNF-α), chemokines, for example, MCP-1 (Monocyte chemotactic protein-1) by microglial cells. This promotes the recruitment of microglial cells to the sites of neuronal damage, and also enhances the formation of the brain protein beta-amyloid (Aβ). The results of modern studies are presented, indicating that platelets are involved in systemic inflammatory reactions, where they interact with monocytes to form monocyte-platelet aggregates (MTA), which induce the activation of monocytes with a pro inflammatory phenotype. In the last decade, it has been established that activated platelets and other cells of the immune system, including monocytes, detached microvesicles (MV) from the membrane. It has been shown that MV are involved as messengers in the transport of biologically active lipids, cytokines, complement, and other molecules that can cause exacerbation of systemic inflammatory reactions. The presented review allows us to expand our knowledge about the cellular and molecular aspects of the interaction of monocytes/macrophages with microglial cells and platelets in the development of neuroinflammation and cognitive decline in the pathogenesis of mental diseases and in AD, and also helps in the search for specific biomarkers of the clinical severity of mental disorder in patients and the prospects for their response to treatment.

Sir James Crichton Browne, 1840-1938

1939 ◽  
Vol 2 (7) ◽  
pp. 519-521
Keyword(s):  
Mental Disorders ◽  
Royal Society ◽  
Mental Hospital ◽  
Charles Darwin ◽  
High Standard ◽  
Standard Of Care ◽  
The West ◽  
Mental Hospitals ◽  
Medical Superintendent ◽  
Care And Treatment

On 31 January 1938, Sir James Crichton-Browne died a few months after his 97th birthday. In him the Royal Society lost its oldest Fellow, both in age and in membership, for he was elected Fellow in 1883, Charles Darwin being one of his proposers. His father, Dr W. A. F. Browne, who was the first Medical Superintendent of the Crichton Royal Mental Hospital at Dumfries, was largely responsible for the high standard of care and treatment of the insane for which this institution has since been famous ; later he became Commissioner in Lunacy in Scotland. It was therefore not surprising that after qualifying in medicine in Edinburgh University at the age of 22, his son decided to devote himself to the study of mental disorders. After serving in junior posts in various county Mental Hospitals he was appointed in 1866 Medical Superintendent of the West Riding Asylum, at Wakefield, a post he held until 1875. It was here his most valuable researches and pioneering work was done.

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