Evolution, Expression, and Sensation, Cell Life and Pathology. By John Cleland, M.D., F.R.S.

1882 ◽  
Vol 28 (123) ◽  
pp. 397-404
Keyword(s):  
John Cleland ◽  
Cell Life

Mechanoregulation of Aortic Valvular Interstitial Cell Life and Death

2015 ◽  
Vol 25 (1-2) ◽  
pp. 3-16 ◽  
Author(s):  
Heather A. Cirka ◽  
Mehmet H. Kural ◽  
Kristen L. Billiar
Keyword(s):  
Interstitial Cell ◽  
Life And Death ◽  
Cell Life

scholarly journals Harnessing Extracellular Matrix Biology for Tumor Drug Delivery

2021 ◽  
Vol 11 (2) ◽  
pp. 88
Author(s):  
Nithya Subrahmanyam ◽  
Hamidreza Ghandehari
Keyword(s):  
Drug Delivery ◽  
Extracellular Matrix ◽  
Cancer Progression ◽  
Active Role ◽  
Reciprocal Relationship ◽  
Design Parameters ◽  
Cancer Etiology ◽  
Cell Life ◽  
Tumor Drug Delivery ◽  
Signaling Interactions

The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and other components. It is also highly involved in cancer progression. Because of its role in cancer etiology, the ECM holds opportunities for cancer therapy on several fronts. There are targets in the tumor-associated ECM at the level of signaling molecules, enzyme expression, protein structure, receptor interactions, and others. In particular, the ECM is implicated in invasiveness of tumors through its signaling interactions with cells. By capitalizing on the biology of the tumor microenvironment and the opportunities it presents for intervention, the ECM has been investigated as a therapeutic target, to facilitate drug delivery, and as a prognostic or diagnostic marker for tumor progression and therapeutic intervention. This review summarizes the tumor ECM biology as it relates to drug delivery with emphasis on design parameters targeting the ECM.

Sign in / Sign up

Export Citation Format

Share Document