scholarly journals Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Katherine H. O. Deane ◽  
Oluseyi F. Jimoh ◽  
Priti Biswas ◽  
Alex O'Brien ◽  
Sarah Hanson ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Depression Symptoms ◽  
Depression And Anxiety ◽  
Omega 3 ◽  
Polyunsaturated Fat ◽  
Alpha Linolenic Acid ◽  
Omega 6 ◽  
3 Omega ◽  
Long Chain

BackgroundThere is strong public belief that polyunsaturated fats protect against and ameliorate depression and anxiety.AimsTo assess effects of increasing omega-3, omega-6 or total polyunsaturated fat on prevention and treatment of depression and anxiety symptoms.MethodWe searched widely (Central, Medline and EMBASE to April 2017, trial registers to September 2016, ongoing trials updated to August 2019), including trials of adults with or without depression or anxiety, randomised to increased omega-3, omega-6 or total polyunsaturated fat for ≥24 weeks, excluding multifactorial interventions. Inclusion, data extraction and risk of bias were assessed independently in duplicate, and authors contacted for further data. We used random-effects meta-analysis, sensitivity analyses, subgrouping and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) assessment.ResultsWe included 31 trials assessing effects of long-chain omega-3 (n = 41 470), one of alpha-linolenic acid (n = 4837), one of total polyunsaturated fat (n = 4997) and none of omega-6. Meta-analysis suggested that increasing long-chain omega-3 probably has little or no effect on risk of depression symptoms (risk ratio 1.01, 95% CI 0.92–1.10, I2 = 0%, median dose 0.95 g/d, duration 12 months) or anxiety symptoms (standardised mean difference 0.15, 95% CI 0.05–0.26, I2 = 0%, median dose 1.1 g/d, duration 6 months; both moderate-quality evidence). Evidence of effects on depression severity and remission in existing depression were unclear (very-low-quality evidence). Results did not differ by risk of bias, omega-3 dose, duration or nutrients replaced. Increasing alpha-linolenic acid by 2 g/d may increase risk of depression symptoms very slightly over 40 months (number needed to harm, 1000).ConclusionsLong-chain omega-3 supplementation probably has little or no effect in preventing depression or anxiety symptoms.Declaration of interestL.H. and A.A. were funded to attend the World Health Organization Nutrition Guidance Expert Advisory Group (NUGAG) Subgroup on Diet and Health meetings and present review results. The authors report no other conflicts of interest.

scholarly journals Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials

2020 ◽  
Vol 122 (8) ◽  
pp. 1260-1270 ◽  
Author(s):  
Sarah Hanson ◽  
◽  
Gabrielle Thorpe ◽  
Lauren Winstanley ◽  
Asmaa S. Abdelhamid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Omega 3 ◽  
Randomised Trials ◽  
Polyunsaturated Fat ◽  
Omega 6 ◽  
3 Omega

scholarly journals Omega-3, Omega-6, and Polyunsaturated Fat for Cognition: Systematic Review and Meta-analysis of Randomized Trials

2020 ◽  
Vol 21 (10) ◽  
pp. 1439-1450.e21 ◽  
Author(s):  
Julii S. Brainard ◽  
Oluseyi F. Jimoh ◽  
Katherine H.O. Deane ◽  
Priti Biswas ◽  
Daisy Donaldson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Omega 3 ◽  
Polyunsaturated Fat ◽  
Omega 6 ◽  
3 Omega

scholarly journals Creation of a database to assess effects of omega-3, omega-6 and total polyunsaturated fats on health: methodology for a set of systematic reviews

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e029554 ◽  
Author(s):  
Lee Hooper ◽  
Asmaa Abdelhamid ◽  
Julii Brainard ◽  
Katherine H O Deane ◽  
Fujian Song
Keyword(s):  
Health Outcomes ◽  
Systematic Reviews ◽  
Sensitivity Analyses ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Trial Duration ◽  
Omega 6 ◽  
3 Omega ◽  
Meta Analyses ◽  
Total Pufa

ObjectiveTo create a database of long-term randomised controlled trials (RCTs) comparing higher with lower omega-3, omega-6 or total polyunsaturated fatty acid (PUFA), regardless of reported outcomes, and to develop methods to assess effects of increasing omega-6, alpha-linolenic acid (ALA), long-chain omega-3 (LCn3) and total PUFA on health outcomes.DesignSystematic review search, methodology and meta-analyses.Data sourcesMedline, Embase, CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov and trials in relevant systematic reviews.Eligibility criteriaRCTs of ≥24 weeks' duration assessing effects of increasing ALA, LCn3, omega-6 or total PUFAs, regardless of outcomes reported.Data synthesisMethods included random-effects meta-analyses and sensitivity analyses. Funnel plots were examined, and subgrouping assessed effects of intervention type, replacement, baseline diabetes risk and use of diabetic medications, trial duration and dose. Quality of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsElectronic searches generated 37 810 hits, de-duplicated to 19 772 titles and abstracts. We assessed 2155 full-text papers, conference abstracts and trials registry entries independently in duplicate. Included studies were grouped into 363 RCTs comparing higher with lower omega-3, omega-6 and/or total PUFA intake of at least 6 months’ duration—the Database.Of these 363 included RCTs, 216 RCTs were included in at least one of our reviews of health outcomes, data extracted and risk of bias assessed in duplicate. Ninety five RCTs were included in the Database but not included in our current reviews. Of these 311 completed trials, 27 altered ALA intake, 221 altered LCn3 intake and 16 trials altered omega-3 intake without specifying whether ALA or LCn3. Forty one trials altered omega-6 and 59 total PUFA.The remaining 52 trials are ongoing though 13 (25%) appear to be outstanding, or constitute missing data.ConclusionsThis extensive database of trials is available to allow assessment of further health outcomes.

scholarly journals The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (3) ◽  
pp. 340 ◽  
Author(s):  
Simeng Wang ◽  
Qi Sun ◽  
Lingling Zhai ◽  
Yinglong Bai ◽  
Wei Wei ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Depression Scale ◽  
Middle School Student ◽  
Chinese Economy ◽  
Anxiety Symptoms ◽  
Depression Symptoms ◽  
Depression And Anxiety ◽  
Obese Children ◽  
Prevalence Of Depression ◽  
Scale Types

With the dramatic growth of the Chinese economy, the number of children/adolescents with being overweight/having obesity is increasing, which has a certain impact on their psychology, such as depression and anxiety symptoms. Our purpose was to conduct a meta-analysis to assess the prevalence and odds ratios of depression and anxiety symptoms among overweight/obese children/adolescents and non-overweight/obese children/adolescents in China. As of July 2018, the three most comprehensive computerized academic databases in China have been systematically screened, namely China national knowledge infrastructure (CNKI) databases, Wanfang databases and Vip databases. The same operations are performed in PubMed and Web of Science (SCIE) databases without language restrictions. Case-control studies on prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China were analyzed. Study selection and evaluation were performed independently by three authors. Unweighted prevalence, pooled random-effects estimates of odds ratio (OR), and 95% confidence intervals (CI) were all calculated. A total of 11 eligible studies involving 17,894 subjects were included. The prevalence of depression and anxiety symptoms in overweight/obese children/adolescents was significantly higher than that in non-overweight/non-obese children/adolescents (depression: 21.73% vs. 17.96%, OR = 1.46, 95% CI: 1.14, 1.87, p = 0.003; anxiety: 39.80% vs. 13.99%, OR = 1.47, 95% CI: 1.21, 1.79, p < 0.001). Subgroup analyses conducted according to scale types showed that scale types have certain significance to evaluate the relationship between depression symptoms and overweight/obesity. The OR of depression symptoms between overweight/obese children/adolescents and non-overweight/non-obese children/adolescents was greatest on the Middle School Student Mental Health Scale (MSSMHS) was 2.06 (95% CI: 1.41, 3.02, I2 = 0.00%), Center for Epidemiologic Studies Depression Scale (CES-D) was 1.03 (95% CI: 0.84, 1.25, I2 = 0.00%), and Children’s Depression Inventory (CDI) was 1.21 (95% CI: 1.02, 1.42, I2 = 0.00%). We concluded that the prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China is higher than that in the non-overweight/obese children/adolescents. The results of the study indicate that the prevalence of depression and anxiety symptoms among overweight/obese children/adolescents in Chinese medical institutions should receive more attention. Physical exercise and psychological interventions should be strengthened to prevent psychological problems. However, because of some clear limitations (no clinical interview and few studies), these results should be interpreted with caution.

scholarly journals Post-secondary Student Mental Health During COVID-19: A Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Jenney Zhu ◽  
Nicole Racine ◽  
Elisabeth Bailin Xie ◽  
Julianna Park ◽  
Julianna Watt ◽  
...  
Keyword(s):  
Mental Health ◽  
Secondary Students ◽  
Meta Analysis ◽  
Well Being ◽  
Anxiety Symptoms ◽  
Depression Symptoms ◽  
Depression And Anxiety ◽  
Post Secondary ◽  
Meta Analyses ◽  
Post Secondary Students

The COVID-19 pandemic has posed notable challenges to post-secondary students, causing concern for their psychological well-being. In the face of school closures, academic disruptions, and constraints on social gatherings, it is crucial to understand the extent to which mental health among post-secondary students has been impacted in order to inform support implementation for this population. The present meta-analysis examines the global prevalence of clinically significant depression and anxiety among post-secondary students during the COVID-19 pandemic. Several moderator analyses were also performed to examine sources of variability in depression and anxiety prevalence rates. A systematic search was conducted across six databases on May 3, 2021, yielding a total of 176 studies (1,732,456 participants) which met inclusion criteria. Random-effects meta-analyses of 126 studies assessing depression symptoms and 144 studies assessing anxiety symptoms were conducted. The pooled prevalence estimates of clinically elevated depressive and anxiety symptoms for post-secondary students during the COVID-19 pandemic was 30.6% (95% CI: 0.274, 0.340) and 28.2% (CI: 0.246, 0.321), respectively. The month of data collection and geographical region were determined to be significant moderators. However, student age, sex, type (i.e., healthcare student vs. non-healthcare student), and level of training (i.e., undergraduate, university or college generally; graduate, medical, post-doctorate, fellow, trainee), were not sources of variability in pooled rates of depression and anxiety symptoms during the pandemic. The current study indicates a call for continued access to mental health services to ensure post-secondary students receive adequate support during and after the COVID-19 pandemic.Systematic Review Registration: PROSPERO website: https://www.crd.york.ac.uk/prospero/, identifier: CRD42021253547.

Suplementação de Ácidos Graxos Poli-insaturados de cadeia longa durante a gestação e fatores associados ao desenvolvimento infantil

2021 ◽  
Vol 11 (1) ◽  
pp. e5736
Author(s):  
Tanuzy de Almeida Souza ◽  
Leila Magda Rodrigues Almeida ◽  
Cinthia Soares Lisboa
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Child Growth ◽  
Primary Role ◽  
Omega 3 ◽  
Before And After ◽  
Omega 6 ◽  
The Central Nervous System ◽  
3 Omega ◽  
Long Chain

O objetivo deste estudo é descrever os benefícios do consumo dos ácidos graxos poli-insaturados durante a gestação e fatores associados no desenvolvimento infantil. Trata-se de uma revisão bibliográfica integrativa, a partir da análise de artigos científicos indexados nas bases de dados MedLine, Scielo, Science Direct e Google acadêmico, com recorte temporal de dez anos (2010-2020). Os descritores utilizados foram: ácido graxopoli-insaturados de cadeia longa; ômega 3; ômega 6; gestante e lactente, no idioma português e inglês, com o auxílio do operador boleano “AND”. Os resultados da pesquisa, após os critérios de inclusão e exclusão, obtiveram um total de 12 artigos. Os estudos demonstraram que os ácidos graxos poli-insaturados de cadeia longa (LCPUFA), tais como os das séries ômega 3 e ômega 6, em especial ácido docosahexaenóico e ácido eicosapentaenóico são fundamentais para o crescimento e desenvolvimento infantil, e tem função primordial na formação e no funcionamento do sistema nervoso central e da retina, e melhora do peso ao nascer. Além disso, os LCPUFA atuam nas gestantes reduzindo riscos de prematuridade, possui função antiinflamatória e antioxidante, reduz o estresse oxidativo, e controla os sintomas depressivos pré e pós-gestação. Conduto, são necessários mais estudos que abordem as quantidades adequadas para o período gestacional favorável à saúde materno-infantil.AbstractThis study aims to describe the benefits of consuming polyunsaturated fatty acids during pregnancy and the associated factors in child development. This is an integrative bibliographic review, based on the analysis of scientific articles indexed in the MedLine, Scielo, Science Direct and Google academic databases, with a ten-year period (2010-2020). The descriptors used were: Long chain fatty polyunsaturated acid; Omega 3; Omega 6; pregnant woman and infant in Portuguese and English, with the assistance of the Boolean operator “AND”. The results of the research, after the inclusion and exclusion criteria, obtained a total of 12 articles. Studies have shown that long-chain polyunsaturated fatty acids (LCPUFA), such as those from the omega 3 and omega 6 series, especially docosahexaenoic acid and eicosapentaenoic acid, are essential for child growth and development, and have a primary role in the formation and in the functioning of the central nervous system and the retina and improves birth weight. In addition, in pregnant women it works by reducing the risk of prematurity. The LCPUFA have an anti-inflammatory and antioxidant function, reduce oxidative stress, and control depressive symptoms before and after pregnancy. However, further studies are needed to address the appropriate quantities for the gestational period favorable to the mother-child health.Keywords: Polyunsaturated fatty acid; Omega 3; Omega 6; Pregnant; Infant.ResumenEl objetivo de este estudio es describir los beneficios de consumir ácidos grasos poliinsaturados durante el embarazo y los factores asociados en el desarrollo infantil. Se trata de una revisión bibliográfica integradora, basada en el análisis de artículos científicos indexados en las bases de datos académicas MedLine, Scielo, Science Direct y Google, con un período de diez años (2010-2020). Los descriptores utilizados fueron: ácido graso poliinsaturado de cadena larga; omega 3; omega 6; embarazada y lactante, en portugués e inglés, con la ayuda del operador booleano “AND”. Los resultados de la investigación, luego de los criterios de inclusión y exclusión, obtuvieron un total de 12 artículos. Los estudios han demostrado que los ácidos grasos poliinsaturados de cadena larga (AGPICL), como los de las series omega 3 y omega 6, especialmente el ácido docosahexaenoico y el ácido eicosapentaenoico, son esenciales para el crecimiento y desarrollo infantil y tienen un papel principal en la formación y en el funcionamiento del sistema nervioso central y la retina, y mejora del peso al nacer. Además, los AGPICL actúan en mujeres embarazadas reduciendo el riesgo de prematurez, tienen una función antiinflamatoria y antioxidante, reducen el estrés oxidativo y controlan los síntomas depresivos antes y después del embarazo. Sin embargo, se necesitan más estudios para abordar las cantidades apropiadas para el período gestacional favorable a la salud de la madre y su hijo.Palabras Clave: Ácido graso poliinsaturado; Omega 3; Omega 6; Embarazada; Infante.

scholarly journals Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials

BMJ ◽  
2019 ◽  
pp. l4697 ◽  
Author(s):  
Tracey J Brown ◽  
Julii Brainard ◽  
Fujian Song ◽  
Xia Wang ◽  
Asmaa Abdelhamid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glucose Metabolism ◽  
Randomised Controlled Trials ◽  
Controlled Trials ◽  
Omega 3 ◽  
Omega 6 ◽  
3 Omega ◽  
Randomised Controlled ◽  
Total Pufa ◽  
Long Chain

AbstractObjectiveTo assess effects of increasing omega-3, omega-6, and total polyunsaturated fatty acids (PUFA) on diabetes diagnosis and glucose metabolism.DesignSystematic review and meta-analyses.Data sourcesMedline, Embase, Cochrane CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov, and trials in relevant systematic reviews.Eligibility criteriaRandomised controlled trials of at least 24 weeks’ duration assessing effects of increasing α-linolenic acid, long chain omega-3, omega-6, or total PUFA, which collected data on diabetes diagnoses, fasting glucose or insulin, glycated haemoglobin (HbA1c), and/or homoeostatic model assessment for insulin resistance (HOMA-IR).Data synthesisStatistical analysis included random effects meta-analyses using relative risk and mean difference, and sensitivity analyses. Funnel plots were examined and subgrouping assessed effects of intervention type, replacement, baseline risk of diabetes and use of antidiabetes drugs, trial duration, and dose. Risk of bias was assessed with the Cochrane tool and quality of evidence with GRADE.Results83 randomised controlled trials (mainly assessing effects of supplementary long chain omega-3) were included; 10 were at low summary risk of bias. Long chain omega-3 had little or no effect on likelihood of diagnosis of diabetes (relative risk 1.00, 95% confidence interval 0.85 to 1.17; 58 643 participants, 3.7% developed diabetes) or measures of glucose metabolism (HbA1c mean difference −0.02%, 95% confidence interval −0.07% to 0.04%; plasma glucose 0.04, 0.02 to 0.07, mmol/L; fasting insulin 1.02, −4.34 to 6.37, pmol/L; HOMA-IR 0.06, −0.21 to 0.33). A suggestion of negative outcomes was observed when dose of supplemental long chain omega-3 was above 4.4 g/d. Effects of α-linolenic acid, omega-6, and total PUFA on diagnosis of diabetes were unclear (as the evidence was of very low quality), but little or no effect on measures of glucose metabolism was seen, except that increasing α-linolenic acid may increase fasting insulin (by about 7%). No evidence was found that the omega-3/omega-6 ratio is important for diabetes or glucose metabolism.ConclusionsThis is the most extensive systematic review of trials to date to assess effects of polyunsaturated fats on newly diagnosed diabetes and glucose metabolism, including previously unpublished data following contact with authors. Evidence suggests that increasing omega-3, omega-6, or total PUFA has little or no effect on prevention and treatment of type 2 diabetes mellitus.Systematic review registrationPROSPERO CRD42017064110.

scholarly journals Protein synthesis and degradation in isolated muscle. Effect of ω3 and ω6 fatty acids

1987 ◽  
Vol 242 (2) ◽  
pp. 615-618 ◽  
Author(s):  
R M Palmer ◽  
K W J Wahle
Keyword(s):  
Fatty Acids ◽  
Protein Synthesis ◽  
Linolenic Acid ◽  
Essential Fatty Acids ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Omega 6 ◽  
3 Omega ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

The ability of derivatives of the essential fatty acids linoleic acid (C18:2, omega 6) and alpha-linolenic acid (C18:3, omega 3) to stimulate rates of protein synthesis and degradation was investigated in isolated intact muscles from fasted rabbits. Both omega 6 derivatives examined, arachidonic acid (C20:4, omega 6) and dihomo-gamma-linolenic acid (C20:3, omega 6), when added at concentrations up to 1 microM, stimulated the rate of protein synthesis and the release of prostaglandin F2 alpha (PGF2 alpha). Metabolites of the omega 6 series, namely eicosapentaenoic acid (C20:5, omega 3) and docosahexaenoic acid (C22:6, omega 3), were without effect on the rate of protein synthesis and resulted in a decrease in the release of PGF2 alpha. None of the fatty acids had a significant effect on the rate of protein degradation. Although insulin (100 mu units/ml) also stimulated rates of protein synthesis when added alone, none of the omega 3 or omega 6 fatty acids, when added with insulin at concentrations of 0.2 microM, potentiated the effect of the hormone.

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