scholarly journals Significant concordance of genetic variation that increases both the risk for obsessive–compulsive disorder and the volumes of the nucleus accumbens and putamen

2018 ◽  
Vol 213 (1) ◽  
pp. 430-436 ◽  
Author(s):  
Derrek P. Hibar ◽  
Joshua W. Cheung ◽  
Sarah E. Medland ◽  
Mary S. Mufford ◽  
Neda Jahanshad ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Obsessive Compulsive ◽  
Brain Volumes ◽  
Compulsive Disorder ◽  
Subcortical Brain ◽  
Risk Variants ◽  
Genome Wide ◽  
The Relationship

BackgroundMany studies have identified changes in the brain associated with obsessive–compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures.MethodUsing single nucleotide polymorphism effect concordance analysis, we measured genetic overlap between the first genome-wide association study (GWAS) of OCD (1465 participants with OCD, 5557 controls) and recent GWASs of eight subcortical brain volumes (13 171 participants).ResultsWe found evidence of significant positive concordance between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes. When conditioning OCD risk variants on brain volume, variants influencing putamen, amygdala and thalamus volumes were associated with risk for OCD.ConclusionsThese results are consistent with current OCD neurocircuitry models. Further evidence will clarify the relationship between putamen volume and OCD risk, and the roles of the detected variants in this disorder.Declaration of interestThe authors have declared that no competing interests exist.

scholarly journals Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

2014 ◽  
Vol 20 (3) ◽  
pp. 337-344 ◽  
Author(s):  
M Mattheisen ◽  
J F Samuels ◽  
Y Wang ◽  
B D Greenberg ◽  
A J Fyer ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Genome-wide association study of obsessive-compulsive disorder

2012 ◽  
Vol 18 (7) ◽  
pp. 788-798 ◽  
Author(s):  
S E Stewart ◽  
◽  
D Yu ◽  
J M Scharf ◽  
B M Neale ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Erratum: Genome-wide association study of obsessive-compulsive disorder

2013 ◽  
Vol 18 (7) ◽  
pp. 843-843
Author(s):  
S E Stewart ◽  
◽  
D Yu ◽  
J M Scharf ◽  
B M Neale ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders

2021 ◽  
Author(s):  
William R Reay ◽  
Dylan J Kiltschewskij ◽  
Michael P Geaghan ◽  
Joshua R Atkins ◽  
Vaughan J Carr ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Causal Effect ◽  
Study Data ◽  
Obsessive Compulsive ◽  
Biochemical Traits ◽  
Compulsive Disorder ◽  
Reactive Protein ◽  
Genome Wide ◽  
The Relationship

There is a long-standing interest in exploring the relationship between blood-based biomarkers of biological exposures and psychiatric disorders, despite their causal role being difficult to resolve in observational studies. In this study, we leverage genome-wide association study data for a large panel of heritable biochemical traits measured from serum to refine our understanding of causal effect in biochemical-psychiatric trait parings. In accordance with expectation we observed widespread evidence of positive and negative genetic correlation between psychiatric disorders and biochemical traits. We then implemented causal inference to distinguish causation from correlation and found strong evidence that C-reactive protein (CRP) exerts a causal effect on psychiatric disorders, along with other putatively causal relationships involving urate and glucose. Strikingly, these analyses suggested CRP has a protective effect on three disorders including anorexia nervosa, obsessive-compulsive disorder, and schizophrenia, whilst being a risk factor for major depressive disorder. Multivariable models that conditioned CRP effects on interleukin-6 signalling and body mass index suggested that CRP-schizophrenia relationship was not likely mediated by those factors. Collectively, these data suggest that there are shared pathways that influence both biochemical traits and psychiatric illness, including factors such as CRP that are likely to constitute a causal effect and could be targets for therapeutic intervention and precision medicine.

The Price of Love: An Investigation into the Relationship between Romantic Love and the Expression of Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2021 ◽  
pp. 1-33
Author(s):  
James McLauchlan ◽  
Emma M. Thompson ◽  
Ygor A. Ferrão ◽  
Euripedes C. Miguel ◽  
Lucy Albertella ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Romantic Love ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Relationship

scholarly journals The Mediating Role of Alexithymia in the Relationship of Coping Strategies and Personality Traits With Obsessive-Compulsive Disorder

2021 ◽  
Vol 27 (1) ◽  
pp. 62-81
Author(s):  
Masoud Bagheri ◽  
◽  
Kazem Nematollah Zadeh Mahani ◽  
Maryam Pour Amrollahi ◽  
◽  
...  
Keyword(s):  
Personality Traits ◽  
Coping Strategies ◽  
Obsessive Compulsive Disorder ◽  
Psychological Health ◽  
Obsessive Compulsive ◽  
Positive Correlation ◽  
Compulsive Disorder ◽  
Mediating Role ◽  
The Relationship

Aims: Obsessive-Compulsive Disorder (OCD) is one of the severe psychological health problems imposing considerable social and economic costs on society. OCD debilitating symptoms can disrupt interpersonal relations, job performance, and life quality. The purpose of this study is to investigate the mediating role of alexithymia in the relationship between coping strategies and personality traits with OCD. Methods & Materials: This is a descriptive correlational study. The study population consists of all people with OCD referred to psychiatric clinics in Kerman City, Iran, during 2018-2019. Of this population, 200 patients were selected using a convenience sampling method. Research instruments included the ways of coping questionnaire, NEO five-factor personality inventory, Toronto alexithymia scale, and Maudsley obsessive-compulsive test. The obtained data were analyzed using the Pearson correlation test and simultaneous and hierarchical regression in SPSS v. 23. Findings: Personality traits had a negative significant correlation with alexithymia (r=0.523, P<0.000) and OCD (r=0.253, P<0.000). Alexithymia had a significant positive correlation with OCD (r=0.272, P<0.000). There was no correlation between problem-focused coping and alexithymia (r=-0.045, P<0.531). There was a positive correlation between emotion-focused coping and OCD (r=0.198, P<0.000). The fit indices indicated a good fit of the proposed model (P<0.005). Conclusion: Alexithymia, as a mediator of the relationship between coping styles and personality traits with OCD, plays an essential role in improving the psychological health of people with OCD.

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