scholarly journals Prediction of electroconvulsive therapy response and remission in major depression: meta-analysis

2018 ◽  
Vol 212 (2) ◽  
pp. 71-80 ◽  
Author(s):  
Linda van Diermen ◽  
Seline van den Ameele ◽  
Astrid M. Kamperman ◽  
Bernard C.G. Sabbe ◽  
Tom Vermeulen ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Meta Analysis ◽  
Therapy Response ◽  
Depression Severity ◽  
Clinical Predictors ◽  
Treatment Protocols ◽  
Prisma Statement ◽  
Severity Of Depression ◽  
Psychotic Features

BackgroundElectroconvulsive therapy (ECT) is considered to be the most effective treatment in severe major depression. The identification of reliable predictors of ECT response could contribute to a more targeted patient selection and consequently increased ECT response rates.AimsTo investigate the predictive value of age, depression severity, psychotic and melancholic features for ECT response and remission in major depression.MethodA meta-analysis was conducted according to the PRISMA statement. A literature search identified recent studies that reported on at least one of the potential predictors.ResultsOf the 2193 articles screened, 34 have been included for meta-analysis. Presence of psychotic features is a predictor of ECT remission (odds ratio (OR) = 1.47, P = 0.001) and response (OR = 1.69, P < 0.001), as is older age (standardised mean difference (SMD) = 0.26 for remission and 0.35 for response (P < 0.001)). The severity of depression predicts response (SMD = 0.19, P = 0.001), but not remission. Data on melancholic symptoms were inconclusive.ConclusionsECT is particularly effective in patients with depression with psychotic features and in elderly people with depression. More research on both biological and clinical predictors is needed to further evaluate the position of ECT in treatment protocols for major depression.Declaration of interestNone.

scholarly journals Prediction of Electroconvulsive Therapy Response and Remission in Major Depression: Meta-analysis – CORRIGENDUM

2018 ◽  
Vol 212 (5) ◽  
pp. 322-322 ◽  
Author(s):  
Linda van Diermen ◽  
Seline van den Ameele ◽  
Astrid M. Kamperman ◽  
Bernard C.G. Sabbe ◽  
Tom Vermeulen ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Meta Analysis ◽  
Therapy Response

SummaryThis notice describes a correction to the above mentioned paper.

COMT val158met influence on electroconvulsive therapy response in major depression

2009 ◽  
Vol 9999B ◽  
pp. n/a-n/a ◽  
Author(s):  
Katharina Domschke ◽  
Maxim Zavorotnyy ◽  
Julia Diemer ◽  
Sarina Nitsche ◽  
Christa Hohoff ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Therapy Response ◽  
Comt Val158met

scholarly journals Adolescent depression, adult mental health and psychosocial outcomes at 30 and 35 years

2016 ◽  
Vol 46 (7) ◽  
pp. 1401-1412 ◽  
Author(s):  
G. F. H. McLeod ◽  
L. J. Horwood ◽  
D. M. Fergusson
Keyword(s):  
Mental Health ◽  
Major Depression ◽  
Partner Violence ◽  
Functional Outcomes ◽  
Adolescent Depression ◽  
Unplanned Pregnancy ◽  
Equation Modeling ◽  
Limited Information ◽  
Depression Severity ◽  
Severity Of Depression

BackgroundThere is limited information on long-term outcomes of adolescent depression. This study examines the associations between severity of depression in adolescence and a broad array of adult functional outcomes.MethodData were gathered as part of the Christchurch Health and Development Study, a 35-year longitudinal study of a birth cohort of 1265 children born in Christchurch, New Zealand in 1977. Severity of depression at age 14–16 years was classified into three levels according to DSM symptom criteria for major depression (no depression/sub-threshold symptoms/major depression). This classification was related to adult functional outcomes assessed at ages 30 and 35 years using a generalized estimating equation modeling approach. Outcome measures spanned domains of mental disorder, education/economic circumstances, family circumstances and partner relationships.ResultsThere were modest but statistically significant bivariate associations between adolescent depression severity and most outcomes. After covariate adjustment there remained weak but significant (p < 0.05) associations with rates of major depression, anxiety disorder, illicit substance abuse/dependence, any mental health problem and intimate partner violence (IPV) victimization. Estimates of attributable risk for these outcomes ranged from 3.8% to 7.8%. For two outcomes there were significant (p < 0.006) gender interactions such that depression severity was significantly related to increased rates of unplanned pregnancy and IPV victimization for females but not for males.ConclusionsThe findings reinforce the importance of the individual/family context in which adolescent depression occurs. When contextual factors and probable maturational effects are taken into account the direct effects of adolescent depression on functioning in mature adulthood appear to be very modest.

Electroconvulsive Therapy and Depression with Psychotic Symptoms: a Case Report

2011 ◽  
Vol 26 (S2) ◽  
pp. 1136-1136
Author(s):  
A. Castillo ◽  
M. Lloret ◽  
M. Harto ◽  
A. Tatay ◽  
C. Almonacid ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Bipolar Affective Disorder ◽  
Manic Episode ◽  
Antipsychotic Agents ◽  
Pharmacological Therapy ◽  
Psychotic Symptoms ◽  
Antipsychotic Treatment ◽  
Psychotic Features ◽  
Depressive Episodes

IntroductionPsychotic symptoms in depression are indicators of severity and poor prognosis. It usually requires psychopharmacotherapy with antidepressants and antipsychotic agents and it may even require electroconvulsive therapy (ECT).Aims, methodologyTo review the indications of ECT in major depression through the study of a clinical case of a patient admitted in an indoor psychiatric unit.ResultsA 64-year-old woman diagnosed as bipolar affective disorder 20 years ago. Her first manic episode required hospitalization. Afterwards, she remained clinically stable for 18 years with pharmacotherapy with lithium. Lately she was admitted due to a major depressive episode with psychotic features (injury delusions, ruin and catastrophe). Antidepressant and antipsychotic treatment was added, improving her symptoms. However, she had to be readmitted two months later with severe psychotic symptoms that did not improve with pharmacological treatment. ECT was added to her treatment. She improved after a few sessions. During the last years, she has presented depressive episodes with psychotic symptoms at least once a year, and all of them have required ECT.ConclusionsECT is an alternative to pharmacological therapy in depression with psychotic symptoms in patients with no response to drugs. According to studies and clinical practice, ETC has been effective as we see in this case. Therefore, ECT is a technique to consider in major depression, not only in patients who do not respond to drug therapy but also in those who do not tolerate psychopharmacological, who suffer from severe or psychotic symptoms, suicide thoughts or those, psychomotor agitation or stupor.

scholarly journals Relapse Following Successful Electroconvulsive Therapy for Major Depression: A Meta-Analysis

2013 ◽  
Vol 38 (12) ◽  
pp. 2467-2474 ◽  
Author(s):  
Ana Jelovac ◽  
Erik Kolshus ◽  
Declan M McLoughlin
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Meta Analysis
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