scholarly journals The Danish National Schizophrenia Project: prospective, comparative longitudinal treatment study of first-episode psychosis

2005 ◽  
Vol 186 (5) ◽  
pp. 394-399 ◽  
Author(s):  
Bent Rosenbaum ◽  
Kristian Valbak ◽  
Susanne Harder ◽  
Per Knudsen ◽  
Anne Køster ◽  
...  
Keyword(s):  
Psychodynamic Psychotherapy ◽  
First Episode Psychosis ◽  
Integrated Treatment ◽  
First Episode ◽  
Treatment As Usual ◽  
Episode Psychosis ◽  
Educational Treatment ◽  
Prospective Longitudinal ◽  
Drug And Alcohol ◽  
Longitudinal Treatment

BackgroundFirst-episode psychosis intervention may improve the course and outcome of schizophrenic disorders.AimsTo describe the Danish National Schizophrenia Project and to measure the outcome of two different forms of intervention after 1 year, compared with standard treatment.MethodA prospective, longitudinal, multicentre investigation included 562 patients, consecutively referred over a 2-year period, with a first episode of psychosis. Patients were allocated to supportive psychodynamic psychotherapy as a supplement to treatment as usual, an integrated, assertive, psychosocial and educational treatment programme or treatment as usual.ResultsThere was a non-significant tendency towards greater improvement in social functioning in the integrated treatment group and the supportive psychodynamic psychotherapy group compared with the treatment as usual group. Significance was reached for some measures when the confounding effect of drug and alcohol misuse was included.ConclusionsIntegrated treatment and supportive psychodynamic psychotherapy in addition to treatment as usual may improve outcome after 1 year of treatment for people with first-episode psychosis, compared with treatment as usual alone.

scholarly journals OPUS study: Suicidal behaviour, suicidal ideation and hopelessness among patients with first-episode psychosis

2002 ◽  
Vol 181 (S43) ◽  
pp. s98-s106 ◽  
Author(s):  
M. Nordentoft ◽  
P. Jeppesen ◽  
M. Abel ◽  
P. Kassow ◽  
L. Petersen ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behaviour ◽  
Female Gender ◽  
First Episode Psychosis ◽  
Integrated Treatment ◽  
High Risk Group ◽  
First Episode ◽  
Treatment As Usual ◽  
Episode Psychosis

BackgroundPatients with first-episode psychosis comprise a high-risk group in terms of suicide.AimsTo identify predictive factors for suicidal behaviour and to examine the effect of integrated treatment on suicidal behaviour and hopelessness.MethodA total of 341 patients with a first-episode schizophrenia-spectrum disorder were randomised to integrated treatment or treatment as usual.ResultsDuring the 1-year follow-up period, 11% attempted suicide. This was associated with female gender, hopelessness, hallucinations and suicide attempt reported at baseline, with the two latter variables being the only significant ones in the final multivariate model. The integrated treatment reduced hopelessness.ConclusionsHallucinations and suicide attempt before inclusion in the study were the most significant predictors of suicide attempt in the follow-up period.

Supportive Psychodynamic Psychotherapy versus Treatment as Usual for First-Episode Psychosis: Two-Year Outcome

Psychiatry ◽  
2012 ◽  
Vol 75 (4) ◽  
pp. 331-341 ◽  
Author(s):  
Bent Rosenbaum ◽  
Susanne Harder ◽  
Per Knudsen ◽  
Anne Køster ◽  
Anne Lindhardt ◽  
...  
Keyword(s):  
Psychodynamic Psychotherapy ◽  
First Episode Psychosis ◽  
First Episode ◽  
Treatment As Usual ◽  
Episode Psychosis ◽  
Versus Treatment

The efficacy of an integrated treatment in comparison with treatment as usual in a group of youths with first-episode psychosis

2012 ◽  
Vol 60 (5) ◽  
pp. S284-S285 ◽  
Author(s):  
Z. Shahrivar ◽  
J. Alaghband-Rad ◽  
J. Mahmoudi Gharaie ◽  
A. Seddigh ◽  
N. Salesian ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
Integrated Treatment ◽  
First Episode ◽  
Treatment As Usual ◽  
Episode Psychosis

Integrated treatment ameliorates negative symptoms in first episode psychosis—results from the Danish OPUS trial

2005 ◽  
Vol 79 (1) ◽  
pp. 95-105 ◽  
Author(s):  
A. Thorup ◽  
L. Petersen ◽  
P. Jeppesen ◽  
J. Øhlenschlæger ◽  
T. Christensen ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
Integrated Treatment ◽  
First Episode ◽  
Episode Psychosis

scholarly journals S107. RANDOMIZED CONTROL TRIAL OF A MOBILE APP-BASED INTERVENTION FOR ADOLESCENTS WITH FIRST-EPISODE PSYCHOSIS: THE THINK APP

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S75-S75
Author(s):  
Ana Calvo ◽  
Teresa Sanchez-Gutierrez ◽  
Sara Barbeito ◽  
Maria Mayoral ◽  
Miguel Moreno ◽  
...  
Keyword(s):  
New Technologies ◽  
Psychiatric Treatment ◽  
Psychological Intervention ◽  
Intervention Group ◽  
First Episode Psychosis ◽  
Mobile App ◽  
First Episode ◽  
Control Group ◽  
Treatment As Usual ◽  
Episode Psychosis

Abstract Background Technological advances in psychiatric treatment is relatively recent. Previous studies have shown an improvement, in the access to treatment, for patients with first-episode psychosis (FEP). This new therapeutic approach may provide patients with personalized, flexible, and evidence-based interventions in their communities and even in their own homes. The aim of this study is to develop and test the effectiveness of a mobile app–based intervention to improve community functioning in adolescents with FEP. Methods We designed a single-blind randomized clinical trial (RCT) to study the effectiveness of a mobile app–based intervention for adolescents with FEP aged 14–19 years recruited from Gregorio Marañón Hospital, Madrid, Spain. Patients were randomly assigned to an intervention group, which received treatment as usual plus five modules of a psychological intervention through the mobile app (psychoeducation, recognition of symptoms and prevention of relapses, problem solving, mindfulness, and contact wall), or to a control group (standard care). Results The effectiveness of the intervention were assessed by means of an extensive battery of clinical tests at baseline and at 3 months of follow-up. The primary outcome was reduction in psychotic and depressive symptoms; secondary outcomes comprise adherence, awareness, use of drugs, and quality of life. Also, will report the usefulness, user experience (UX) and security perceived by adolescents with a PEP: frequency of application use, average time of use, quantitative use, etc. Discussion To our knowledge, this is the first randomized online treatment for adolescent with early psychosis comparison with treatment as usual. The main novelty of our approach is the integration of new technologies with traditional psychoeducation, cognitive behavioral therapy techniques, mindfulness and social skills development.

scholarly journals Longitudinal treatment outcome of African American and Caucasian patients with first episode psychosis

2011 ◽  
Vol 4 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Huijun Li ◽  
Shaun M. Eack ◽  
Debra M. Montrose ◽  
Jean M. Miewald ◽  
Matcheri Keshavan
Keyword(s):  
African American ◽  
Treatment Outcome ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Caucasian Patients ◽  
Longitudinal Treatment

scholarly journals Differentiating the Effect of Medication and Illness on Brain Volume Reductions in First-Episode Psychosis: A Longitudinal, Randomized, Triple-blind, Placebo-controlled MRI study

2020 ◽  
Author(s):  
Sidhant Chopra ◽  
Alex Fornito ◽  
Shona M. Francey ◽  
Brian O’Donoghue ◽  
Vanessa Cropley ◽  
...  
Keyword(s):  
Atypical Antipsychotics ◽  
Psychotic Disorders ◽  
Brain Volume ◽  
First Episode Psychosis ◽  
First Episode ◽  
Control Group ◽  
Grey Matter Volume ◽  
Significant Group ◽  
Episode Psychosis ◽  
Prospective Longitudinal

AbstractBackgroundPsychotic disorders are associated with reductions in brain volume, but the timing and causes of these reductions remain unclear. In particular, the effects of antipsychotic medication and illness have been difficult to disentangle due to a lack of prospective, longitudinal, randomized placebo-controlled designs.MethodsWe conducted a triple-blind randomised placebo-controlled trial where 62 antipsychotic naïve patients with first episode psychosis (FEP) received either an atypical antipsychotic or a placebo pill over a treatment period of 6 months. Both FEP groups received intensive psychosocial therapy. A healthy control group (n=27) was also recruited. Structural MRI scans were obtained at baseline, 3-months and 12-months. Our primary aim was to differentiate illness-related brain volume changes from medication-related changes within the first 3 months of treatment. We secondarily investigated long-term effects at the 12-month timepoint.OutcomeFrom baseline to 3 months, we observed a significant group × time interaction in the pallidum, such that patients receiving atypical antipsychotics showed increased volume, patients on placebo showed decreased volume, and healthy controls showed no change. In patients, a greater increase in pallidal grey matter volume over 3 months was associated with a greater reduction in symptom severity, consistent with a neuroprotective effect of atypical antipsychotics. We additionally found preliminary evidence for illness-related volume reductions in prefrontal cortices at 12 months and putative antipsychotic-related neurotoxicity in cerebellum at both 3-months and 12-months.InterpretationOur findings indicate that psychotic illness and antipsychotic exposure exert distinct and spatially distributed effects on brain volume. Our results align with prior work in suggesting that the therapeutic efficacy of antipsychotics may be primarily mediated through their effects on the basal ganglia.Trial registrationACTRN12607000608460.

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