Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism∗

1999 ◽  
Vol 174 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Kara E. Hayford ◽  
Christi A. Patten ◽  
Teresa A. Rummans ◽  
Darrell R. Schroeder ◽  
Kenneth P. Offord ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Past History ◽  
Initial Period ◽  
Smoking Abstinence ◽  
End Of Treatment ◽  
History Of ◽  
One Year ◽  
Dose Response Effect

BackgroundA past history of major depression or alcoholism has been associated with poorer smoking treatment outcomes.AimTo evaluate the efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism, and changes in depressive symptoms during smoking abstinence.MethodData were drawn from a multicentre trial of bupropion for smoking cessation. Smokers (n=615) received placebo or bupropion sustained-release at 100, 150, or 300 mg/day for six weeks after target quit date (TQD). The primary outcome was the point prevalence smoking abstinence at the end of treatment and at one year. The Beck Depression Inventory (BDI) was used to assess depressive symptoms.ResultsA significant dose – response effect of bupropion for smoking cessation was found. This was independent of history of major depression or alcoholism. Among those continuously abstinent from smoking for two weeks following TQD, an increase in BDI score was associated with a return to smoking at end of treatment.ConclusionsBupropion is efficacious for smoking cessation independently of a former history of major depression or alcoholism. Increases in depressive symptoms during an initial period of abstinence are associated with a return to smoking.

scholarly journals Neuropsychological deficits in past suicide attempters with varying levels of depression severity

2014 ◽  
Vol 44 (14) ◽  
pp. 2965-2974 ◽  
Author(s):  
J. G. Keilp ◽  
S. R. Beers ◽  
A. K. Burke ◽  
N. M. Melhem ◽  
M. A. Oquendo ◽  
...  
Keyword(s):  
Working Memory ◽  
Major Depression ◽  
Rating Scale ◽  
Suicide Attempts ◽  
Past History ◽  
Clinical State ◽  
Suicide Attempters ◽  
History Of ◽  
Attention Memory ◽  
Interference Processing

BackgroundOur previous work identified deficits in interference processing and learning/memory in past suicide attempters who were currently depressed and medication-free. In this study, we extend this work to an independent sample studied at various stages of illness and treatment (mild symptoms, on average) to determine if these deficits in past suicide attempters are evident during a less severe clinical state.MethodA total of 80 individuals with a past history of major depression and suicide attempt were compared with 81 individuals with a history of major depression and no lifetime suicide attempts on a battery of neurocognitive measures assessing attention, memory, abstract/contingent learning, working memory, language fluency and impulse control.ResultsPast attempters performed more poorly in attention, memory and working memory domains, but also in an estimate of pre-morbid intelligence. After correction for this estimate, tests that had previously distinguished past attempters – a computerized Stroop task and the Buschke Selective Reminding Test – remained significantly worse in attempters. In a secondary analysis, similar differences were found among those with the lowest levels of depression (Hamilton Depression Rating Scale score <10), suggesting that these deficits may be trait markers independent of current symptomatology.ConclusionsDeficits in interference processing and learning/memory constitute an enduring defect in information processing that may contribute to poor adaptation, other higher-order cognitive impairments and risk for suicidal behavior.

scholarly journals Direct Participation in and Indirect Exposure to the Occupy Central Movement and Depressive Symptoms: A Longitudinal Study of Hong Kong Adults

2016 ◽  
Vol 184 (9) ◽  
pp. 636-643 ◽  
Author(s):  
Michael Y. Ni ◽  
Tom K. Li ◽  
Herbert Pang ◽  
Brandford H. Y. Chan ◽  
Betty Y. Yuan ◽  
...  
Keyword(s):  
Hong Kong ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Patient Health Questionnaire ◽  
Health Questionnaire ◽  
Personal Involvement ◽  
Patient Health ◽  
Population Mental Health ◽  
History Of ◽  
Occupy Central

Abstract Despite the extensive history of social movements around the world, the evolution of population mental health before, during, and after a social movement remains sparsely documented. We sought to assess over time the prevalence of depressive symptoms during and after the Occupy Central movement in Hong Kong and to examine the associations of direct and indirect exposures to Occupy Central with depressive symptoms. We longitudinally administered interviews to 909 adults who were randomly sampled from the population-representative FAMILY Cohort at 6 time points from March 2009 to March 2015: twice each before, during, and after the Occupy Central protests. The Patient Health Questionnaire-9 was used to assess depressive symptoms and probable major depression (defined as Patient Health Questionnaire-9 score ≥10). The absolute prevalence of probable major depression increased by 7% after Occupy Central, regardless of personal involvement in the protests. Higher levels of depressive symptoms were associated with online and social media exposure to protest-related news (incidence rate ratio (IRR) = 1.28, 95% confidence interval (CI): 1.06, 1.55) and more frequent Facebook use (IRR = 1.38, 95% CI: 1.12, 1.71). Higher levels of intrafamilial sociopolitical conflict was associated with more depressive symptoms (IRR = 1.05, 95% CI: 1.01, 1.09). The Occupy Central protests resulted in substantial and sustained psychological distress in the community.

scholarly journals The Effect of Mood, Anxiety, and Alcohol Use Disorders on Smoking Cessation in Cancer Patients

2011 ◽  
Vol 25 (1) ◽  
pp. 82-96 ◽  
Author(s):  
Janice A. Blalock ◽  
Cho Lam ◽  
Jennifer A. Minnix ◽  
Maher Karam-Hage ◽  
Ellen R. Gritz ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Major Depression ◽  
Alcohol Abuse ◽  
Anxiety Disorders ◽  
Psychiatric Disorders ◽  
Cancer Patients ◽  
Mental Illnesses ◽  
End Of Treatment ◽  
Axis I ◽  
The Relationship

Smoking is highly prevalent in individuals with psychiatric disorders. The relationship between smoking and anxiety disorders has received less attention than that of depression and substance use disorders, despite the fact that anxiety disorders are the most common of mental illnesses across the globe. In this study, we investigated the relationship between psychiatric disorders, including anxiety, depression, alcohol abuse, and comorbid combinations of these primary Axis I disorders and smoking cessation, in a cohort of 1,425 cancer patients who were participating in a smoking cessation clinical program. Patients were followed prospectively and assessed for abstinence status at the end of treatment and at 6-month posttreatment. Treatment involved six to eight behavioral smoking cessation counseling sessions over a 12- to 16-week period, and up to 12 weeks of smoking cessation pharmacotherapy. We hypothesized that patients with current anxiety disorders as well as other psychiatric disorders would have lower smoking cessation rates than those with no psychiatric disorders. There were no differences in abstinence rates between patients with anxiety disorders and those with no psychiatric disorders at end of treatment or 6 months. Patients with major depression or alcohol abuse had lower cessation rates than patients with no psychiatric disorders at 6 months. Findings suggest that both major depression and alcohol abuse may adversely affect treatment outcome in cancer patients. However, these findings should be considered within the limitations of observational studies that involve comparisons between nonrandomly assigned groups.

Predictors of Depression 12 Months after Cardiac Hospitalization: The Identifying Depression as a Comorbid Condition Study

2006 ◽  
Vol 40 (11-12) ◽  
pp. 1025-1030 ◽  
Author(s):  
Geoff Schrader ◽  
Frida Cheok ◽  
Ann-Louise Hordacre ◽  
Julie Marker
Keyword(s):  
Depressive Symptoms ◽  
Emotional Health ◽  
Past History ◽  
Depression Scale ◽  
Severe Depression ◽  
Self Report ◽  
Comorbid Condition ◽  
Multinomial Regression ◽  
Mild Depression ◽  
History Of

Objective: To determine characteristics which predict depression at 12 months after cardiac hospitalization, and track the natural history of depression. Method: Depressive symptoms were monitored at baseline, 3 and 12 months in a cohort of 785 patients, using the self-report Center for Epidemiological Studies Depression Scale. Multinomial regression analyses of baseline clinical and demographic variables identified characteristics associated with depression at 12 months. Results: Three baseline variables predicted moderate to severe depression at 12 months: depression during index admission, past history of emotional health problems and current smoking. For those who were depressed during cardiac hospitalization, 51% remained depressed at both 3 and 12 months. Persistence was more evident in patients who had moderate to severe depressive symptoms when hospitalized. Mild depression was as likely to persist as to remit. Conclusions: Three clinically accessible characteristics at the time of cardiac hospitalization can assist in predicting depression at 12 months and may aid treatment decisions. Depressive symptoms persist in a substantial proportion of cardiac patients up to 12 months after hospitalization.

scholarly journals Surgical Management of Bicornual Uterine Prolapse in a Siamese Cat: A Case Report

2020 ◽  
pp. 320-323
Keyword(s):  
Surgical Management ◽  
Uterine Prolapse ◽  
Past History ◽  
Rare Condition ◽  
Operative Management ◽  
Visual Examination ◽  
Siamese Cat ◽  
History Of ◽  
One Year ◽  
Veterinary Hospital

Uterine prolapse is a rare condition in cats that can be managed by performing either an external hysterectomy or manual reduction followed by ovariohysterectomy. This article describes surgical management of bilateral uterine prolapse in a queen. A one year old female, pluriparous Siamese cat (Felis catus) with no past history of dystocia and weighing 2.8 kg was presented to Andys Veterinary hospital, Nairobi, Kenya with a protruding mass through the vulval. The queen had a history of recent queening and had delivered three kittens a week earlier. The owner noticed the protruding mass about 24 hours after the delivery of the last neonate. A few days later, the cat was not suckling the kittens well and was in appetent. As a sequel to this, two kittens died. After a week, the protruding mass had a pungent smell and the client presented the cat to the hospital. Complete bilateral uterine prolapse was diagnosed after a visual examination and palpation of the mass. The uterus was swollen, had necrotic areas and debris. Accordingly, a two staged ovariohysterectomy was opted for to manage the case. An internal ovariectomy was first done via a ventral midline celiotomy followed by an external hysterectomy. Post-operative management included pain medication and antibiotic therapy and the patient recovered well and was discharged after 2 days. The skin sutures were removed 10 days postoperatively. The cat recovered uneventfully with no further complications reported by the owner. In conclusion, this article shows that when the prolapsed uterus is swollen, damaged and necrotic, a two staged ovariohysterectomy should be the method of treatment and the outcome is good despite the duration of the condition.

scholarly journals Hydatid disease with Aspergilloma: A unique case report

2021 ◽  
Vol 91 (1) ◽  
Author(s):  
Sandeep Sharma ◽  
Parikshit Thakare ◽  
Ketaki Utpat ◽  
Unnati Desai
Keyword(s):  
Case Report ◽  
Hydatid Disease ◽  
Past History ◽  
Case Reports ◽  
Unique Case ◽  
Rare Finding ◽  
History Of ◽  
One Year

The coexisting presence of hydatid disease with aspergillus colonization is a rare finding. The 20-year-old presented with symptoms of hemoptysis with past history of tuberculosis. On further evaluation, the patient was diagnosed as a case of aspergilloma and managed conservatively. After one year of presenting with similar complaints, the patient was turned out to be hydatid disease with aspergillus colonization on the basis of clinic-radiological and bronchoscopic evaluation. Till now only a few case reports have been reported. We report a unique case report of a similar presentation.

scholarly journals Efficacy of bupropion for relapse prevention in smokers with and without a past history of major depression

2004 ◽  
Vol 19 (8) ◽  
pp. 828-834 ◽  
Author(s):  
Lisa Sanderson Cox ◽  
Christi A. Patten ◽  
Raymond S. Niaura ◽  
Paul A. Decker ◽  
Nancy Rigotti ◽  
...  
Keyword(s):  
Major Depression ◽  
Relapse Prevention ◽  
Past History ◽  
History Of
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