Commentary on: Randomised, double-blind, placebo-controlled trial of fluoxetine and graded exercise for chronic fatigue syndrome†

1998 ◽  
Vol 172 (6) ◽  
pp. 491-492 ◽  
Author(s):  
Alicia Deale ◽  
Trudie Chalder ◽  
Simon Wessely
Keyword(s):  
Randomised Controlled Trial ◽  
Chronic Fatigue Syndrome ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Fatigue Syndrome ◽  
Graded Exercise ◽  
Randomised Controlled

A variety of treatments for chronic fatigue syndrome (CFS) have been proposed but few have been systematically evaluated. The publication of this well-designed, double-blind, randomised controlled trial is therefore a welcome contribution to the literature.

scholarly journals Results of the feasibility phase of the managed activity graded exercise in teenagers and pre-adolescents (MAGENTA) randomised controlled trial of treatments for chronic fatigue syndrome/myalgic encephalomyelitis

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Amberly Brigden ◽  
Lucy Beasant ◽  
Daisy Gaunt ◽  
William Hollingworth ◽  
Nicola Mills ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Chronic Fatigue Syndrome ◽  
Young People ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Graded Exercise ◽  
Activity Management ◽  
Randomised Controlled

Abstract Background Chronic fatigue syndrome (CFS) also known as myalgic encephalomyelitis (ME) is relatively common in young people and causes significant disability. Graded exercise therapy (GET) and activity management are recommended by the National Institute for Health and Care Excellence (NICE) despite a limited evidence-base for either treatment in paediatric CFS/ME. This paper reports on feasibility and acceptability measures from the feasibility phase of the ongoing MAGENTA randomised controlled trial (RCT) investigating GET versus activity management for young people with CFS/ME. Methods Setting: Three specialist secondary care National Health Service (NHS) Paediatric CFS/ME services (Bath, Cambridge and Newcastle). Participants: Young people aged 8–17 years with a diagnosis of mild to moderate CFS/ME. Young people were excluded if they were severely affected, referred to cognitive behavioural therapy (CBT) at initial assessment or unable to attend clinical sessions. Interventions: GET and activity management delivered by physiotherapists, occupational therapists, nurses and psychologists. Families and clinicians decided the number (typically 8–12) and frequency of appointments (typically every 2–6 weeks). Outcome Measures: Recruitment and follow-up statistics. We used integrated qualitative methodology to explore the feasibility and acceptability of the trial processes and the interventions. Results 80/161 (49.7%) of eligible young people were recruited at two sites between September 2015 and August 2016, indicating recruitment to the trial was feasible. Most recruitment (78/80; 97.5%) took place at one centre. Recruitment consultations, online consent and interventions were acceptable, with less than 10% in each arm discontinuing trial treatment. Response rate to the primary outcome (the SF36-PFS at 6 months) was 91.4%. Recruitment, treatment and data collection were not feasible at one centre. The site was withdrawn from the study. In response to data collected, we optimised trial processes including using Skype for recruitment discussions; adapting recruiter training to improve recruitment discussions; amending the accelerometer information leaflets; shortening the resource use questionnaires; and offering interventions via Skype. These amendments have been incorporated into the full trial protocol. Conclusions Conducting an RCT investigating GET versus activity management is feasible and acceptable for young people with CFS/ME. Trial registration ISRCTN23962803 10.1186/ISRCTN23962803, date of registration: 03 September 2015

Randomised controlled trial of graded exercise in chronic fatigue syndrome

2004 ◽  
Vol 180 (9) ◽  
pp. 444-448 ◽  
Author(s):  
Karen E Wallman ◽  
Alan R Morton ◽  
Carmel Goodman ◽  
Robert Grove ◽  
Andrew M Guilfoyle
Keyword(s):  
Randomised Controlled Trial ◽  
Chronic Fatigue Syndrome ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Graded Exercise ◽  
Randomised Controlled

Immunologic and psychologic therapy for patients with chronic fatigue syndrome: A double-blind, placebo-controlled trial

1993 ◽  
Vol 94 (2) ◽  
pp. 197-203 ◽  
Author(s):  
Andrew R. Lloyd ◽  
Ian Hickie ◽  
Alan Brockman ◽  
Catherine Hickie ◽  
Andrew Wilson ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Fatigue Syndrome

A Randomized, Double-Blind, Placebo-Controlled Trial of Moclobemide in Patients With Chronic Fatigue Syndrome

2000 ◽  
Vol 61 (9) ◽  
pp. 643-648 ◽  
Author(s):  
Ian B. Hickie ◽  
Andrew J. Wilson ◽  
J. Murray Wright ◽  
Barbara K. Bennett ◽  
Denis Wakefield ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Controlled Trial ◽  
Chronic Fatigue ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Fatigue Syndrome
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