scholarly journals Measuring cognitive deterioration in Alzheimer's disease

1997 ◽  
Vol 170 (6) ◽  
pp. 580-580 ◽  
Author(s):  
G. R. J. Swanwick ◽  
M. J. Rowan ◽  
R. F. Coen ◽  
B. A. Lawlor ◽  
D. Coakley
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deterioration

The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer's disease patients

2012 ◽  
Vol 198 (2) ◽  
pp. 263-268 ◽  
Author(s):  
Gianfranco Spalletta ◽  
Carlo Caltagirone ◽  
Paolo Girardi ◽  
Walter Gianni ◽  
Anna Rosa Casini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Major Depression ◽  
Cognitive Deterioration ◽  
Newly Diagnosed

Disease progression model for cognitive deterioration from Alzheimer's Disease Neuroimaging Initiative database

2010 ◽  
Vol 7 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Kaori Ito ◽  
Brian Corrigan ◽  
Qinying Zhao ◽  
Jonathan French ◽  
Raymond Miller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Cognitive Deterioration ◽  
Progression Model ◽  
Disease Progression Model

Ambulatory Blood Pressure Characteristics of Patients with Alzheimer’s Disease: A Multicenter Study from China

2021 ◽  
Vol 83 (3) ◽  
pp. 1333-1339
Author(s):  
Hualong Wang ◽  
Ying Xu ◽  
Rujing Ren ◽  
Feng Yao ◽  
Mei Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Multicenter Study ◽  
Systolic Hypertension ◽  
Cognitive Deterioration ◽  
Ambulatory Bp Monitoring ◽  
Severe Stage ◽  
Reverse Dipping

Background: Previous studies revealed that abnormal blood pressure (BP) plays an important role in the pathogenesis of Alzheimer’s disease (AD). However, little is known about the ambulatory BP characteristics of AD in the mild or severe stage. Objective: We explored the ambulatory BP characteristics of AD in the mild or severe stage. Methods: In the present study, 106 AD patients (42.5%male, average age 81.6 years) were enrolled from three centers in China. Clinal BP measurements at the supine and standing positions, neurological evaluations, and the 24 h ambulatory BP monitoring were performed. Results: In the 106 AD patients, 49.2%, 36.8%, and 70%of patients had 24 h, daytime, and nighttime systolic hypertension, respectively, while 19.8%, 29.2%, and 5.7%had 24 h, daytime, and nighttime diastolic hypotension. The prevalence of the reduced and reverse dipping pattern was 34.0%and 48.1%for systolic BP and 32.1%and 45.3%for diastolic BP, respectively. The daytime diastolic BP was significantly correlated with cognitive performance. After adjustment for age, sex, and body mass index, only daytime diastolic BP was associated with remarkable cognitive deterioration (p≤0.008). Further, AD patients in the severe stage had significantly lower levels of the 24 h, daytime, and nighttime diastolic BP, compared with those in the mild stage. Conclusion: In general, AD patients were featured with high nighttime systolic BP, low daytime diastolic BP, and abnormal circadian BP rhythm of reduced and reverse dipping. The diastolic BP, especially daytime diastolic BP, was adversely correlated with the cognitive deterioration in AD.

Disinhibition, Apathy, Indifference, Fatigability, Complaining, and Negativism

1997 ◽  
Vol 8 (S3) ◽  
pp. 403-408 ◽  
Author(s):  
Joy Webster ◽  
George T. Grossberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Homes ◽  
Behavioral Problems ◽  
Sleep Disturbances ◽  
Cognitive Deterioration ◽  
Mood Changes ◽  
Wide Range ◽  
Sexual Disturbances

A wide range of neuropsychiatric disturbances, which include noncognitive behavioral problems and mood changes, can accompany the unrelenting cognitive deterioration seen in patients with Alzheimer's disease. Aggression, agitation, paranoia, hallucinations, sleep disturbances, or depression occur in more than 50% of patients with Alzheimer's disease, both those living in the community and those cared for in nursing homes. Disinhibition, apathy, indifference, fatigability, complaining, and negativism, as well as incontinence, changes in appetite, and sexual disturbances, also occur in patients with dementia.

P1-346: Acceleration of brain atrophy rates with advancing cognitive deterioration from normal aging to MCI to Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S223-S223 ◽  
Author(s):  
Norbert Schuff ◽  
Philip Insel ◽  
Gloria Chiang ◽  
Diana Truran ◽  
Anthony Gamst ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Normal Aging ◽  
Cognitive Deterioration

The picture-naming task in the analysis of cognitive deterioration in Alzheimer's disease

Aphasiology ◽  
2005 ◽  
Vol 19 (6) ◽  
pp. 545-557 ◽  
Author(s):  
Fernando Cuetos ◽  
María Gonzalez-Nosti ◽  
Carmen Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Picture Naming ◽  
Naming Task ◽  
Cognitive Deterioration
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