Prevalence of Familiality, Obstetric Complications, and Structural Brain Damage in Schizophrenic Patients

1988 ◽  
Vol 153 (2) ◽  
pp. 191-197 ◽  
Author(s):  
V. L. Nimgaonkar ◽  
S. Wessely ◽  
R. M. Murray
Keyword(s):  
Family History ◽  
Brain Damage ◽  
Obstetric Complications ◽  
Ventricular Enlargement ◽  
Clinical Variables ◽  
Structural Brain Damage ◽  
Schizophrenic Patients ◽  
History Of ◽  
Structural Brain

Schizophrenic in-patients with and without a family history were identified prospectively. The two groups did not differ with respect to clinical variables, ventricular enlargement, prevalence of cortical sulcal widening, or a history of obstetric complications, even when a variety of definitions of familiality were used.

Schizophrenics with a family history of bipolar disorder. Possible involvement of obstetric complications

1993 ◽  
Vol 8 (4) ◽  
pp. 223-226
Author(s):  
H Verdoux ◽  
M Bourgeois
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Case Reports ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of ◽  
The Continuum

SummaryThe case reports of two DSM III-R schizophrenic patients with a family history of bipolar disorder are presented. The two patients had a history of severe obstetric complications (OCs). These cases are discussed in the light of neurodevelopmental theories of schizophrenia and in the continuum view of psychosis.

scholarly journals Prolonged Methamphetamine-Induced Psychosis: Difference With Schizophrenia

2019 ◽  
Author(s):  
Hamid Reza Ahmadkhaniha ◽  
Kaveh Alavi ◽  
Fatemeh Hadi
Keyword(s):  
Family History ◽  
Obstetric Complications ◽  
Medical Sciences ◽  
Neurological Soft Signs ◽  
Demographic Questionnaire ◽  
Significant Difference ◽  
Other Substances ◽  
Schizophrenic Patients ◽  
History Of ◽  
Close Relatives

The main objective of the present study was to compare the distribution of underlying factors such as neurological soft signs, obstetric complications, and family history of psychiatric disorders between two groups of schizophrenic patients and patients with prolonged methamphetamine-induced psychosis. In a case-control study, 30 patients with prolonged methamphetamine-induced psychosis and 30 patients with schizophrenia were selected. Data were collected through a demographic questionnaire, the Buchanan and Heinrichs’ Neurological Evaluation Scale (NES), the Lewis-Murray’s Obstetric Complications Scale (LMOCS), and the Weissman’s Family History Screen (FHS). Mean scores of the neurological soft signs (±SD) in the two groups of schizophrenic patients and patients with prolonged methamphetamine-induced psychosis were 15.7±8.7 and 11.7±6.2, respectively (P=0.040), and a significant difference was observed in the sensory integration between the two groups (P=0.022). Obstetric complications revealed similar distributions in the two groups. Patients with prolonged methamphetamine-induced psychosis reported higher prevalence of alcohol and other substances use disorders (P=0.003 and P=0.001, respectively) in their close relatives; however, the distributions of other disorders were not statistically different between the two groups’ close relatives. Similarities and differences in certain aspects were observed between the two groups, suggesting susceptibility for psychosis in patients with prolonged methamphetamine-induced psychosis; yet we found diversities that distinguish the two disorders. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(4):235-243

The Nithsdale Schizophrenia Surveys X: Obstetric Complications, Family History and Abnormal Movements

1992 ◽  
Vol 160 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Robin G. McCreadie ◽  
David J. Hall ◽  
Ian J. Berry ◽  
Lesley J. Robertson ◽  
James I. Ewing ◽  
...  
Keyword(s):  
Family History ◽  
Tardive Dyskinesia ◽  
Psychiatric Illness ◽  
Obstetric Complications ◽  
Degree Relative ◽  
Drug Induced ◽  
Abnormal Movements ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
History Of

Obstetric histories of 54 schizophrenic patients and 114 siblings were obtained from their mothers and scored using the Obstetric Complications Scale. There was no statistically significant difference in the proportion of schizophrenic patients (35%) and siblings (29%) who had at least one definite obstetric complication. There was no evidence that schizophrenic patients with a history of obstetric complications were less likely to have a first-degree relative with a history of psychiatric illness leading to in-patient care. Schizophrenic patients with a history of obstetric complications were more likely to have drug-induced Parkinsonism. There was a trend for tardive dyskinesia to be more common in those schizophrenic patients with no obstetric complications but a family history of schizophrenia.

Obstetric complications in patients with schizophrenia and their unaffected siblings

2005 ◽  
Vol 20 (1) ◽  
pp. 28-34 ◽  
Author(s):  
M. Walshe ◽  
C. McDonald ◽  
M. Taylor ◽  
J. Zhao ◽  
P. Sham ◽  
...  
Keyword(s):  
Risk Factor ◽  
Family History ◽  
Genetic Susceptibility ◽  
Environmental Risk ◽  
Obstetric Complications ◽  
Control Group ◽  
Environmental Risk Factor ◽  
Schizophrenic Patients ◽  
History Of ◽  
Elevated Rate

AbstractObjectiveWe sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia.MethodsThe presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group.ResultsOCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings.ConclusionOur data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes.

scholarly journals The Nithsdale Schizophrenia Surveys

1994 ◽  
Vol 165 (3) ◽  
pp. 340-346 ◽  
Author(s):  
R. G. Mccreadie ◽  
M. A. Connolly ◽  
D. J. Williamson ◽  
R. W. B. Athawes ◽  
D. Tilak-Singh
Keyword(s):  
Family History ◽  
Personality Traits ◽  
Social Adjustment ◽  
Obstetric Complications ◽  
Childhood And Adolescence ◽  
Schizotypal Personality ◽  
Clinical Correlates ◽  
Syndrome Scale ◽  
Schizophrenic Patients ◽  
History Of

BackgroundThe aim was to examine in a population of schizophrenic patients the clinical correlates of ‘neurodevelopmental’ schizophrenia and their relationship to putative aetiological factors.MethodPremorbid social adjustment, premorbid schizoid and schizotypal personality traits, and the obstetric history of 40 schizophrenic patients and their 102 sibs were assessed through interviews with their mothers. Patients' premorbid level of intelligence was assessed by the National Adult Reading Test and current symptoms by the Positive and Negative Syndrome Scale and the Subjective Deficit Syndrome Scale.ResultsPatients had more schizoid and schizotypal traits than their sibs. They showed a deterioration in social adjustment between childhood and adolescence; sibs' social adjustment improved. There were statistically significant associations between current negative schizophrenic symptoms, premorbid deterioration in social adjustment, and schizoid and schizotypal personality traits, and between an early age of onset of illness and the same premorbid assessments. There was no evidence that patients with a family history of severe mental illness leading to hospitalisation, or a history of definite obstetric complications, had poorer premorbid functioning or more severe current symptoms.ConclusionsWe have confirmed clinical correlates of ‘neurodevelopmental’ schizophrenia but found no association between these and obstetric complications or a family history of severe mental disorder.

History of obstetric complications, family history, and CT scan findings in schizophrenic patients

1990 ◽  
Vol 3 (5-6) ◽  
pp. 311-314 ◽  
Author(s):  
Ravinder Reddy ◽  
Sukdeb Mukherjee ◽  
David B. Schnur ◽  
James Chin ◽  
Gustav Degreef
Keyword(s):  
Family History ◽  
Ct Scan ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of

Family History and Cerebral Ventricular Enlargement in Schizophrenia

1989 ◽  
Vol 154 (5) ◽  
pp. 629-634 ◽  
Author(s):  
Michael J. Owen ◽  
Shôn W. Lewis ◽  
Robin M. Murray
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Positive Family History ◽  
Ventricular Enlargement ◽  
Ventricular Size ◽  
Degree Relative ◽  
Distinct Subgroup ◽  
Schizophrenic Patients ◽  
History Of ◽  
Normal Controls

Ventricular size was measured from CT scans in 48 patients meeting RDC for schizophrenia who had a first-degree relative with a history of treatment for major psychiatric disorder, in 48 age- and sex-matched schizophrenic patients with no such history in first- or second-degree relatives, and in 48 matched, healthy controls. There was no difference in ventricular size between those with and without a positive family history, although both groups showed ventricular enlargement with respect to normal controls. Ventricular enlargement was demonstrated in the subgroup of 23 patients with a family history of schizophrenia, but not in the subgroup of 18 patients with a family history of affective disorder. These observations provide further evidence that schizophrenics with a family history of affective disorder may constitute an aetiologically distinct subgroup.

Family history and obstetric complications in deficit and non-deficit schizophrenia: preliminary results

1998 ◽  
Vol 13 (5) ◽  
pp. 270-272 ◽  
Author(s):  
S Dollfus ◽  
S Germain-Robin ◽  
B Chabot ◽  
P Brazo ◽  
P Delamillieure ◽  
...  
Keyword(s):  
Family History ◽  
Environmental Factors ◽  
Obstetric Complications ◽  
Preliminary Results ◽  
Deficit Schizophrenia ◽  
Schizophrenic Patients ◽  
History Of

SummaryThe aim of this study was to test that deficit (D) schizophrenic patients as defined by Carpenter et al had a higher prevalence of family history of schizophrenia but less obstetric complications than non-deficit (ND) patients. A lower rate of obstetric complications but an excess of schizophrenic and a higher rate of alcoholism family antecedents in 18 D patients compared to 23 ND patients were found. These results could suggest that there is a different weight of genetic and early environmental factors in D and ND patients.

Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

1988 ◽  
Vol 18 (3) ◽  
pp. 583-592 ◽  
Author(s):  
V. L. Nimgaonkar ◽  
S. Wessely ◽  
L. E. Tune ◽  
R. M. Murray
Keyword(s):  
Family History ◽  
Prospective Study ◽  
Age Of Onset ◽  
Obstetric Complications ◽  
Early Age ◽  
Ventricular Enlargement ◽  
Familial Predisposition ◽  
History Of ◽  
A Prospective Study ◽  
Antipsychotic Drug Treatment

SynopsisA prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.

scholarly journals Injury protection strategies for H63D syndrome patients suffering from cataplexy

2021 ◽  
Author(s):  
Jacob S Adams ◽  
David Seideman ◽  
Riku Honda ◽  
Lucas Smith ◽  
Carolina Diamandis
Keyword(s):  
Brain Damage ◽  
Surrogate Marker ◽  
Significant Incidence ◽  
Protection Strategies ◽  
Structural Brain Damage ◽  
Injury Protection ◽  
Structural Brain

Abstract Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cataplexy from injury.

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