The Scottish First Episode Schizophrenia Study V. One-year Follow-up

1988 ◽  
Vol 152 (4) ◽  
pp. 470-476 ◽  
Author(s):  
Robin G. McCreadie ◽  
David H. Wiles ◽  
Stewart M. Grant ◽  
John W. Moore ◽  
George T. Crocket ◽  
...  
Keyword(s):  
Block Design ◽  
Community Sample ◽  
First Episode ◽  
Psychometric Assessment ◽  
Schizophrenic Patients ◽  
One Year ◽  
First Episode Schizophrenia ◽  
Flupenthixol Decanoate ◽  
First Admission

Of 49 schizophrenic patients followed up 12 months after their first admission to hospital, only about 45% had experienced no relapse and had no schizophrenic symptoms; a poorer outcome was more often found in Feighner positive than Feighner negative schizophrenic patients. The patients' overall level of unemployment had more than doubled to 51%. In patients whose acute episodes responded to treatment, pimozide taken once weekly as maintenance therapy was as effective as intramuscular flupenthixol decanoate, but tardive dyskinesia appeared in two patients receiving weekly pimozide; the repeat psychometric assessment at 12 months found modest improvements, i.e. no evidence of intellectual decline, in Matrices, Block Design, and Digit Copying tests. Forty per cent of relatives still showed significant psychological distress, which correlated with patients' schizophrenic symptoms, and the relatives' social functioning remained poorer than that of a normal community sample.

The Scottish First Episode Schizophrenia Study

1992 ◽  
Vol 161 (4) ◽  
pp. 496-500 ◽  
Author(s):  
Robin G. McCreadie ◽  
David H. Wiles ◽  
Martin G. Livingston ◽  
James A. G. Watt ◽  
J. G. Greene ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Drug Therapy ◽  
Psychological Stress ◽  
Antipsychotic Drug ◽  
First Episode ◽  
Poor Outcome ◽  
Schizophrenic Patients ◽  
First Episode Schizophrenia ◽  
First Admission

Forty-four schizophrenic patients were followed up for five years after their first admission to hospital for a first episode of illness. Thirteen (30%) of 43 patients had not relapsed; 28 of the 30 patients who did relapse did so within the first 42 months. The relapses occurred despite antipsychotic drug therapy. Also, 24% of patients had at least one course of ECT. Only 19% of the patients at five years were in open employment; unemployment was strongly associated with relapse. Eighteen per cent had neither relapses nor schizophrenic symptoms at follow-up. Poor outcome at five years was associated with greater psychological distress among relatives at first admission. At five years 43% of relatives continued to show case level psychological stress.

Gray matter morphology and the level of functioning in one-year follow-up of first-episode schizophrenia patients

2009 ◽  
Vol 33 (8) ◽  
pp. 1438-1446 ◽  
Author(s):  
Tomas Kasparek ◽  
Radovan Prikryl ◽  
Daniel Schwarz ◽  
Hana Kucerova ◽  
Radek Marecek ◽  
...  
Keyword(s):  
Gray Matter ◽  
First Episode ◽  
Level Of Functioning ◽  
One Year ◽  
First Episode Schizophrenia

Executive function as predictors of persistent thought disorder in first-episode schizophrenia: A one-year follow-up study

2014 ◽  
Vol 159 (2-3) ◽  
pp. 465-470 ◽  
Author(s):  
Jia-Qi Xu ◽  
Christy Lai-Ming Hui ◽  
Julia Longenecker ◽  
Edwin Ho-Ming Lee ◽  
Wing-Chung Chang ◽  
...  
Keyword(s):  
Executive Function ◽  
Thought Disorder ◽  
First Episode ◽  
Follow Up Study ◽  
One Year ◽  
First Episode Schizophrenia

Depression in people with first-episode schizophrenia

1998 ◽  
Vol 172 (S33) ◽  
pp. 90-92 ◽  
Author(s):  
Donald Addington ◽  
Jean Addington ◽  
Scott Patten
Keyword(s):  
Acute Phase ◽  
Depression Scale ◽  
First Episode ◽  
First Year ◽  
Multiple Episode ◽  
Treatment Of Depression ◽  
One Year ◽  
First Episode Schizophrenia ◽  
First Episode Of Schizophrenia

Background Depression has been described in people presenting with first-episode schizophrenia, a group at high relative risk of suicide.Method This was a longitudinal cohort study of 113 people during an acute relapse and 13 having a first episode. Follow-up occurred at three months and at one year. This report compares level of depression in the first episode and in the relapsing group. Levels of depression were assessed using the Calgary Depression Scale for Schizophrenia (CDSS).Results The median CDSS score was statistically significantly higher in the first-episode group both during the acute phase and at three month follow-up. At one year the first-episode group continued to have higher levels of depression than the multiple episode group.Conclusions For people with a first episode of schizophrenia, depression is a major problem during the initial acute phase and during the first year of illness. In light of the high risk of suicide in this population, recognition and treatment of depression requires greater attention.

Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia

2007 ◽  
Vol 22 (8) ◽  
pp. 499-504 ◽  
Author(s):  
Radovan Prikryl ◽  
Eva Ceskova ◽  
Tomas Kasparek ◽  
Hana Kucerova
Keyword(s):  
Temporal Stability ◽  
First Episode ◽  
Index Hospitalization ◽  
Neurological Soft Signs ◽  
Course Of Illness ◽  
Psychiatric Status ◽  
Syndrome Scale ◽  
Schizophrenic Patients ◽  
First Episode Schizophrenia

AbstractObjectivesTo examine the relationship between the severity of neurological soft signs at onset and at the 1-year follow-up of patients with schizophrenia, and to investigate temporal stability of neurological soft signs within 1 year from the onset of the first episode schizophrenia.MethodsThe study included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a 1-year follow-up. The patients were divided into remitters and non-remitters according to their psychiatric status assessed at the 1-year follow-up, using the Positive and Negative Syndrome Scale (PANSS).ResultsA trend for a lower score for the NES item “others” in late remitters versus non-remitters at baseline was found during index hospitalization. At the 1-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within 1 year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within 1 year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score.ConclusionThese findings in a population of patients with first episode schizophrenia are in accord with the findings of previous studies which found an association between neurological soft signs, treatment response and outcome. This association may characterize a subgroup of patients with a poor course of illness and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.

Poster #M204 OUTCOMES OF PATIENTS WITH FIRST-EPISODE SCHIZOPHRENIA AT ONE-YEAR FOLLOW-UP: FINDINGS FROM THE NATIONAL MENTAL HEALTH REGISTRY IN MALAYSIA

2014 ◽  
Vol 153 ◽  
pp. S264
Author(s):  
Kok Yoon Chee ◽  
Norsiatul Azma Muhammad Dain ◽  
Salina Abdul Aziz ◽  
Sharifah Suziah Syed Mokhtar ◽  
Mazni Mat Junus ◽  
...  
Keyword(s):  
Mental Health ◽  
First Episode ◽  
National Mental Health ◽  
One Year ◽  
Health Registry ◽  
First Episode Schizophrenia
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