Electroconvulsive Therapy in Parkinsonism with Affective Disorder

1988 ◽  
Vol 152 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Nutan Atre-Vaidya ◽  
V. Chowdary Jampala
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Effective Treatment ◽  
Affective Disorder ◽  
Electroconvulsive Therapy ◽  
Poor Prognosis ◽  
First Report

The authors report a patient whose Parkinson's disease and mania both responded well to electroconvulsive therapy (ECT) after failing to respond to chemotherapy. The authors review the literature and suggest that ECTis a safe and effective treatment for affective syndromes associated with Parkinsonism. The presence of dementia in these patients appears to be an indicator of poor prognosis. This paper is believed to be the first report of successful use of ECT in mania occurring together with Parkinsonism.

Effective treatment of restless legs syndrome by safinamide in Parkinson's disease patients

2018 ◽  
Vol 41 ◽  
pp. 113-114 ◽  
Author(s):  
Claudio Liguori ◽  
Nicola Biagio Mercuri ◽  
Alessandro Stefani ◽  
Mariangela Pierantozzi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Effective Treatment ◽  
Restless Legs Syndrome ◽  
Restless Legs

scholarly journals Case Studies in Neuroscience: Lack of inhibitory synaptic plasticity in the substantia nigra pars reticulata of a patient with lithium-induced tremor

2019 ◽  
Vol 122 (4) ◽  
pp. 1367-1372 ◽  
Author(s):  
Luka Milosevic ◽  
Robert F. Dallapiazza ◽  
Renato P. Munhoz ◽  
Suneil K. Kalia ◽  
Milos R. Popovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Affective Disorder ◽  
Brain Stimulation ◽  
Bipolar Affective Disorder ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Therapeutic Mechanism ◽  
Deep Brain

Tremor is a well-known side effect from many psychiatric medications, including lithium and dopamine antagonists. In patients whose psychiatric symptoms are stabilized and only respond to certain medications, deep brain stimulation may offer relief of the consequent motor complications. We report the case of an elderly male with disabling tremor related to lithium therapy for bipolar affective disorder, who was subsequently treated with deep brain stimulation. In this patient, we obtained recordings from the substantia nigra pars reticulata and performed a high-frequency stimulation protocol that robustly elicits long-term potentiation (LTP)-like changes in patients with Parkinson’s disease. We hypothesized that in this patient, who did not have Parkinson’s disease, the levels of inhibitory plasticity would be much greater. However, we found an unanticipated lack of plasticity in the patient with lithium-induced tremor, compared with two de novo control patients with Parkinson’s disease. This patient was successfully treated with deep brain stimulation in the vicinity of the ventral oral posterior nucleus, an area of the thalamus that receives inputs from the basal ganglia. We postulate that the lithium-induced blockade of LTP may bring about motor complications such as tremor while simultaneously contributing to the therapeutic mechanism for treating the symptoms of psychiatric disorders such as bipolar affective disorder. NEW & NOTEWORTHY Use of a dual-microelectrode technique enabled us to compare long-term potentiation (LTP)-like changes in a patient with lithium-induced tremor to that of patients with Parkinson’s disease. This study corroborated the findings in rodent brain slices that chronic lithium treatment may block LTP. Whereas a deficit in LTP may underlie the therapeutic mechanism for treating psychiatric disorders such as bipolar affective disorder, it may simultaneously contribute to consequent appearance of tremor.

Catatonic stupor during the course of Parkinson's disease resolved with electroconvulsive therapy

2006 ◽  
Vol 21 (1) ◽  
pp. 123-124 ◽  
Author(s):  
Kazumasa Suzuki ◽  
Shuichi Awata ◽  
Kae Nakagawa ◽  
Takehisa Takano ◽  
Hiroo Matsuoka
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Electroconvulsive Therapy

Bipolar affective disorder and Parkinson's disease: a rare, insidious and often unrecognized association

2002 ◽  
Vol 23 (0) ◽  
pp. s67-s68 ◽  
Author(s):  
A. Cannas ◽  
A. Spissu ◽  
G.L. Floris ◽  
S. Congia ◽  
M.V. Saddi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Affective Disorder ◽  
Bipolar Affective Disorder

Electroconvulsive therapy for depression in a Parkinson's disease patient with bilateral subthalamic nucleus deep brain stimulators

2005 ◽  
Vol 11 (6) ◽  
pp. 403-406 ◽  
Author(s):  
Kelvin L. Chou ◽  
Howard I. Hurtig ◽  
Jurg L. Jaggi ◽  
Gordon H. Baltuch ◽  
Rodney J. Pelchat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Electroconvulsive Therapy ◽  
Disease Patient ◽  
Deep Brain
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