Hereditary Agoraphobia and Obsessive-Compulsive Behaviour in Relatives of Patients with Gilles de la Tourette's Syndrome

1987 ◽  
Vol 151 (2) ◽  
pp. 195-199 ◽  
Author(s):  
D. E. Comings ◽  
B. G. Comings
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Panic Attacks ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genetic Subtypes ◽  
Compulsive Behaviour ◽  
Motor Tics ◽  
Vocal Tics

We present 11 pedigrees in which a propositus with Gilles de la Tourette's syndrome had first or second-degree relatives with obsessive-compulsive behaviour or agoraphobia with panic attacks, but only partially expressed the TS gene (i.e. had only motor tics or vocal tics, or neither). Of 90 females over the age of 18 presenting with TS, or with motor or vocal tics alone, nine had severe agoraphobia with panic attacks. There may be genetic subtypes of both obsessive-compulsive disorder and agoraphobia with panic attacks that are due to partial expression of the TS gene.

Mental Play in Gilles de la Tourette's Syndrome and Obsessive-Compulsive Disorder

1992 ◽  
Vol 161 (4) ◽  
pp. 542-545 ◽  
Author(s):  
D. C. Cath ◽  
B. J. M. van de Wetering ◽  
T. C. A. M. van Woerkom ◽  
C. A. L. Hoogduin ◽  
R. A. C. Roos ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Compulsive Behaviour

A new phenomenon, found only in Gilles de la Tourette (GTS) patients, and which we have called ‘mental play’, is described. It was compared with the phenomenon of counting, which occurred in both GTS and obsessive-compulsive patients. In the GTS patients both mental play and counting were best characterised as playful impulsions. In contrast to the GTS patients, the counting of the obsessive-compulsive patients was in line with their obsessive-compulsive behaviour. These findings suggest that repetitive symptoms in GTS patients, even when they share superficial similarities with obsessive-compulsive symptoms, should not be diagnosed automatically as obsessive-compulsive.

scholarly journals Motor, Behavioral and Pharmacologic Findings in Tourette's Syndrome

1987 ◽  
Vol 14 (S3) ◽  
pp. 541-546 ◽  
Author(s):  
Joseph Jankovic ◽  
Haydee Rohaidy
Keyword(s):  
Family Member ◽  
Sleep Disturbances ◽  
Age Of Onset ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Duration Of Symptoms ◽  
Female Ratio ◽  
Motor Tics ◽  
Vocal Tics

ABSTRACT:We studied 112 patients with Tourette's syndrome (TS); the male-to-female ratio was 3.8, the mean age of onset was 7.3 years, and the average duration of symptoms prior to the initial evaluation was 15.2 years. Seventy-nine percent of the patients had at least one family member with motor or vocal tics, and an additional 10 percent had a family member with marked obsessive-compulsive behavior. Simple motor tics occurred as the presenting symptom in about one-third of patients; one-third had multiple motor tics at the onset, and another third started with vocal tics. During the course of the illness all patients developed multifocal motor tics and 86 percent had vocal tics. Verbal and mental coprolalia was present in 44 percent of the patients. Copropraxia was seen in 19 percent of patients, and both coprolalia and copropraxia were more frequent among the males than expected. Attentional deficit disorder was diagnosed in 36 percent of the patients and 32 percent had obsessive-compulsive personality. Sleep disturbances were reported by 62 percent of the patients and polysomnography in 34 patients showed motor and vocal tics during all stages of sleep, sleep apnea, abnormal arousal pattern, and other sleep disturbances. Patients with mild symptoms improved with clonidine or clonazepam, but those with more advanced disorder required fluphenazine, pimozide, haloperidol or tetrabenazine.

Emergence of Symptoms of Tourette's Syndrome during Fluvoxamine Treatment of Obsessive–Compulsive Disorder

1994 ◽  
Vol 164 (6) ◽  
pp. 839-841 ◽  
Author(s):  
S. Fennig ◽  
S. Naisberg Fennig ◽  
M. Pato ◽  
A. Weitzman
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

A 14-year-old boy with obsessive–compulsive disorder (OCD) developed, under fluvoxamine treatment, acute symptoms of Tourette's syndrome (TS) with aggravation of the OCD. The TS symptoms did not respond to dopamine blockers and disappeared only after withdrawal of fluvoxamine. Readministration of fluvoxamine caused a re-emergence of the same symptoms.

Obsessive-Compulsive Disorder, Tourette's Syndrome, and Basal Ganglia Pathology on MRI

1998 ◽  
Vol 10 (1) ◽  
pp. 116-117 ◽  
Author(s):  
Philip R. Saba ◽  
Khurshed Dastur ◽  
M. Reza Raji ◽  
Matcheri S. Keshavan ◽  
M. Ammar Katerji
Keyword(s):  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Obsessive-compulsive disorder and Tourette’s syndrome

2000 ◽  
Vol 2 (2) ◽  
pp. 125-139 ◽  
Author(s):  
Randall D. Buzan ◽  
Jay H. Shore ◽  
Christopher O’Brien ◽  
Christopher Schneck
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
Sign in / Sign up

Export Citation Format

Share Document