Amitriptyline: Comparison of Three Different Dosage Schedules in Neurotic Depression

1979 ◽  
Vol 135 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Domenico De Maio ◽  
Alessandro Levi-Minzi
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Lower Incidence ◽  
Depression Scale ◽  
The Third ◽  
Depressed Patients ◽  
Self Rating

SummaryThree groups of neurotic depressed patients were treated with amitriptyline, one group receiving the customary three daily doses, another a single dose in the morning, and the third a single dose at night. All three groups showed significant decrements of total scores on the Hamilton Scale for Depression and the Zung Self-Rating Depression Scale without significant differences. Patients taking the drug at night showed a lower incidence of side effects.

A Further Look at the Popoff Index of Depression

1978 ◽  
Vol 42 (1) ◽  
pp. 309-310 ◽  
Author(s):  
Robert J. Rhodes
Keyword(s):  
Factor Analysis ◽  
Depression Scale ◽  
Depressed Patients ◽  
Self Rating

A factor analysis of the Index of Depression and MMPI data from 20 male and 20 female depressed patients suggests that the Index is a useful self-rating measure of depression and that its Covert Depression scale makes a necessary contribution.

scholarly journals Triclabendazole in the treatment of human fascioliasis: a community-based study

1990 ◽  
Vol 5 (5) ◽  
pp. 888-894
Author(s):  
H. El Morshedy ◽  
A. Farghaly ◽  
S. Sharaf ◽  
L. Abou Basha ◽  
R. Barakat
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Community Based ◽  
The Third ◽  
Human Fascioliasis

The efficacy of triclabendazole in the treatment of chronic Fasciola infection was assessed. A total of 134 asymptomatic cases of established Fasciola infection were treated: 68 individuals received a single dose of 10 mg/kg and 66 individuals received 2 doses of 10 mg/kg on 2 consecutive days. Cure was assessed 5 weeks after treatment and 79.4% of the first group and 93.9% of the second group were cured. The drug was well tolerated; no serious side-effects were noted. One patient developed biochemical cholestasis the third day after treatment, but her enzyme profiles returned to normal after 2 months. We conclude triclabendazole is a safe and potent fasciolicidic drug

scholarly journals HYPERTENSION CONTROL AND DEPRESSION A STUDY IN SSPM MEDICAL COLLEGE & LIFETIME HOSPITAL PADAVE SINDHUDURG

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Sheetal Ratankumar Gatagat
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Antihypertensive Therapy ◽  
Depression Scale ◽  
Clinical Severity ◽  
Mean Blood Pressure ◽  
Adequate Treatment ◽  
Hypertensive Patients ◽  
Depressed Patients ◽  
Self Rating

Introduction:  Hypertension is a major public health issue worldwide, affecting millions of patients. Although control rates have improved during the past few years, the actual rate is still unacceptably low, and control rates in more vulnerable populations, like people living with diabetes mellitus, are even lower. Optimal BP control could prevent a high percentage of coronary heart disease events, and early BP control significantly reduces the risk of stroke and cardiovascular events Depression is usually not detected at primary levels, and patients do not typically receive adequate treatment, which may not only affect their quality of life, but may also interfere with the treatment and prognosis of other chronic diseases such as ischemic heart disease and stroke.  Material and Methods: 46 hypertensive patients undergoing antihypertensive therapy for longer than six months were included in the study. After a 5 min of rest period, measurement of BP was recorded in triplicate at 3 min intervals between measurements. Adherence to antihypertensive therapy was monitored. All patients completed the Zung Self-rating Depression Scale survey; depression was diagnosed if the patient scored >50 points (the maximum possible score using this scale was 80). The Zung Self-rating Depression Scale is said to be a sensitive measure of clinical severity in depressed patients. Results: Out of 46 patients there were 22 (47.8%) female and 24(52.2%) male. Patients who were depressed were 20 (43.5%) of which 8(40%) were male and 12 (60%) were female. Of the total 20 depressed patients 1 male having controlled hypertension while 19 (80%) were in the group of uncontrolled diabetes. In controlled hypertension group only 1 mild depression patient was observed while in uncontrolled group of the 19 patients 10 (50%) were having mild, 8 (40%) were having moderate and 1 (20%) were having severe depression according the Zung Self-rating Depression Scale. Mean blood pressure in depressed controlled BP group was 128/73 mmHg while in depressed uncontrolled group was 149/90 mmHg. Mean blood pressure in normal controlled BP group was 121/75mmHg while in depressed uncontrolled group was 146/95 mmHg. There was a significant correlation observed between depression and systolic and diastolic blood pressure value (P<0.001). Conclusion: Depression is common in patients having uncontrolled hypertension and screening of depression in hypertensive patients is simple and effective tool to control the hypertension. Keywords: Hypertension, Depression, controlled, uncontrolled.

scholarly journals HYPERTENSION CONTROL AND DEPRESSION A STUDY IN DATTA MEGHE MEDICAL COLLEGE AND SHALINITAI MEGHE HOSPITAL & RESEARCH CENTRE.

2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Mahendra Sawarkar ◽  
Mukund Ganeriwal ◽  
Shriram Kane
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Antihypertensive Therapy ◽  
Depression Scale ◽  
Clinical Severity ◽  
Mean Blood Pressure ◽  
Research Centre ◽  
Hypertensive Patients ◽  
Depressed Patients ◽  
Self Rating

Introduction:  Hypertension is a major public health issue worldwide, affecting millions of patients. Although control rates have improved during the past few years, the actual rate is still unacceptably low, and control rates in more vulnerable populations, like people living with diabetes mellitus, are even lower. Optimal BP control could prevent a high percentage of coronary heart disease events, and early BP control significantly reduces the risk of stroke and cardiovascular events Depression is usually not detected at primary levels, and patients do not typically receive adequate treatment, which may not only affect their quality of life, but may also interfere with the treatment and prognosis of other chronic diseases such as ischemic heart disease and stroke.  Material and Methods: 46 hypertensive patients undergoing antihypertensive therapy for longer than six months were included in the study. After a 5 min of rest period, measurement of BP was recorded in triplicate at 3 min intervals between measurements. Adherence to antihypertensive therapy was monitored. All patients completed the Zung Self-rating Depression Scale survey; depression was diagnosed if the patient scored >50 points (the maximum possible score using this scale was 80). The Zung Self-rating Depression Scale is said to be a sensitive measure of clinical severity in depressed patients. Results: Out of 46 patients there were 22 (47.8%) female and 24(52.2%) male. Patients who were depressed were 20 (43.5%) of which 8(40%) were male and 12 (60%) were female. Of the total 20 depressed patients 1 male having controlled hypertension while 19 (80%) were in the group of uncontrolled diabetes. In controlled hypertension group only 1 mild depression patient was observed while in uncontrolled group of the 19 patients 10 (50%) were having mild, 8 (40%) were having moderate and 1 (20%) were having severe depression according the Zung Self-rating Depression Scale. Mean blood pressure in depressed controlled BP group was 128/73 mmHg while in depressed uncontrolled group was 149/90 mmHg. Mean blood pressure in normal controlled BP group was 121/75mmHg while in depressed uncontrolled group was 146/95 mmHg. There was a significant correlation observed between depression and systolic and diastolic blood pressure value (P<0.001). Conclusion: Depression is common in patients having uncontrolled hypertension and screening of depression in hypertensive patients is simple and effective tool to control the hypertension. Keywords: Hypertension, depression, controlled, uncontrolled.

scholarly journals Comparison of Prevalence and Risk Factors of PTSS Between Chinese Patients With Depression and Non-depressed Controls During COVID-19 Outbreak

2022 ◽  
Vol 12 ◽  
Author(s):  
Min Peng ◽  
Xinran Song ◽  
Luyu Liu ◽  
Weifeng Zhao ◽  
Pingmei Lai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Traumatic Event ◽  
Linear Regression Analysis ◽  
Depression Scale ◽  
Psychological Status ◽  
Chinese Patients ◽  
Depressed Patients ◽  
Self Rating ◽  
Depressed Group ◽  
The Impact

Background: COVID-19 pandemic is a traumatic event all over the world, and may lead to post-traumatic stress symptom (PTSS) in different population who are under the threat of novel corona virus. Therefore, the aim of our study was to compare the prevalence and risk factors of PTSS between Chinese patients with depression and non-depressed controls during the COVID-19 outbreak.Methods: 437 depressed patients and 2,940 non-depressed controls were enrolled in this cross-sectional study between February 14 and May 9, 2020.The Impact of Events Scale-Revised (IES-R), Zung Self-Rating Depression Scale (SDS), Zung Self-Rating Anxiety Scale (SAS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the psychological status of all the participants.Results: The prevalence of PTSS (IES-R ≥ 33) in depressed patients (45.08%) was higher than that in non-depressed controls (5.31%). Patients with depression were 16 times more likely to suffer from PTSS than those without depression. Correlation analyses showed that the IES-R total score was positively correlated with SDS, SAS, and PSQI scores in both depressed and non-depressed groups (Bonferroni corrected all p &lt; 0.001). Multiple linear regression analysis showed that SAS score, and PSQI score were independently associated with IES-R total score in both depression and non-depression groups. In depressed patients, education level and duration of media exposure to COVID-19 were positively associated with PTSS, while in the non-depressed group, subjects who were married, in the 31–50 year group or with higher SDS score were more likely to develop PTSS.Conclusions: These results indicate that the prevalence rate of PTSS in patients with depression is very higher than that in subjects without depression. PTSS are associated with a number of socio-demographic and clinical variables.

Plasma nortriptyline and clinical response–a study using changing plasma levels

1977 ◽  
Vol 7 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Graham D. Burrows ◽  
Kay P. Maguire ◽  
Bruce A. Scoggins ◽  
James Stevenson ◽  
Brian Davies
Keyword(s):  
Clinical Response ◽  
Plasma Levels ◽  
Depression Scale ◽  
Hamilton Depression Scale ◽  
The Third ◽  
Depressed Patients ◽  
Significant Relationships ◽  
Severity Of Depression

SynopsisIn a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured by the Hamilton Depression Scale, showed no significant relationships. The implications of the study are discussed.

A Comparison of the Therapeutic and Cardiovascular Effects of a Single Nightly Dose of Prothiaden (Dothiepin, Dosulepin) and Lentizol (Sustained-Release Amitriptyline) in Depressed Elderly Patients

1981 ◽  
Vol 9 (2) ◽  
pp. 108-112 ◽  
Author(s):  
A U Khan
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Sustained Release ◽  
Rating Scale ◽  
Depression Scale ◽  
Comparative Trial ◽  
Check List ◽  
Night Time ◽  
Self Rating ◽  
Symptom Check List

This was a single-blind 4-week parallel group comparative trial in fifty depressed patients. Twenty-five patients received 50 mg of Lentizol, a sustained-release form of amitriptyline, and twenty-five received 75 mg of Prothiaden. Both groups took their drugs as a single night-time dose. Patient response was measured on a symptom check-list which was completed by the doctor and a self-rating depression scale. Tolerance was assessed by recording volunteered and observed side-effects and also by taking the pulse, blood pressure and an electrocardiogram before treatment and after 2 and 4 weeks. A statistically better response was seen with Prothiaden at each follow-up assessment (1, 2 and 4 weeks) compared to Lentizol as measured by both the symptom check-list and the self-rating scale. Less side-effects were also seen with Prothiaden. Minor changes were seen in the ECG records of two patients on Prothiaden and three on Lentizol. These changes were not associated with any clinical change in the patients' cardiovascular state. No consistent changes of any clinical significance were seen in the pulse and blood pressure recordings.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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