Platelet and Plasma Amine Oxidase Activity in Alcoholic Individuals

1978 ◽  
Vol 132 (6) ◽  
pp. 548-554 ◽  
Author(s):  
Leslie F. Major ◽  
Dennis L. Murphy
Keyword(s):  
Oxidase Activity ◽  
Amine Oxidase ◽  
Hospital Treatment ◽  
Control Group ◽  
Platelet Mao ◽  
Plasma Amine Oxidase ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Military Control ◽  
Amine Oxidase Activity

SummaryPlatelet and plasma amine oxidase activity was determined in a group of 99 healthy male (active duty military) alcoholics referred for hospital treatment who had been abstinent from alcohol for 2–10 days, and compared with that of a control military group. Platelet MAO activity was slightly but significantly lower in the alcoholic group. Both groups were significantly lower in MAO activity compared to a group of 42 non-military controls. In the alcoholic group there was no correlation between platelet MAO and severity or chronicity of drinking, nor was there evidence of iron deficiency to account for the lowered MAO activity. When the alcoholic and military control groups were split at the median, the first degree relatives of both the ‘low’ MAO alcoholics and the ‘low’ MAO military controls had a higher incidence of alcoholism than did the relatives of both ‘high’ MAO subgroups. No personal or family history data of alcohol-related problems were available on the non-military control group.

Kinetics and Thermolability of Platelet Monoamine Oxidase in Cluster Headache and Migraine

Cephalalgia ◽  
1984 ◽  
Vol 4 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Elisabet Waldenlind ◽  
Jan Sääf ◽  
Karl Ekbom ◽  
Svante Ross ◽  
Lars-Olof Wahlund ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Cluster Headache ◽  
Control Group ◽  
Enzyme Properties ◽  
Headache Disorders ◽  
Platelet Mao ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Platelet Monoamine Oxidase ◽  
C 30

Platelet monoamine oxidase activity (MAO) from 33 cluster headache patients (17 males, 16 females) and 34 migraine patients (16 males, 18 females) was assayed. The kinetic constants (apparent V max and apparent K m ) and the thermolability, measured as the ratio of the platelet MAO activity after and before heat treatment (+52°C, 30 min), were determined. The MAO activity and V max values were significantly lower in cluster headache than in migraine and in both headache disorders compared to a control group (62 males, 66 females). When comparing all groups, K m was not significantly different except for migraine females, who had lower K m values compared to control females. Thermolability was significantly higher in cluster headache than in migraine and in both headache disorders compared to the control group. Smokers of five cigarettes or more per day had significantly lower Vmax values but similar K m and thermolability values compared to those smoking less or nothing. The findings of low maximal velocities and high thermolability of platelet MAO in cluster headache and migraine are suggested to represent constitutionally different enzyme properties.

Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo

1968 ◽  
Vol 17 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Donald S. Robinson ◽  
Walter Lovenberg ◽  
Harry Keiser ◽  
Albert Sjoerdsma
Keyword(s):  
Human Blood ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Blood Platelet ◽  
Human Blood Platelet ◽  
Plasma Amine Oxidase ◽  
Amine Oxidase Activity

Low Platelet Monoamine Oxidase Activity in Sensation-Seeking Bullfighters

CNS Spectrums ◽  
1999 ◽  
Vol 4 (12) ◽  
pp. 21-24 ◽  
Author(s):  
José Luis Carrasco ◽  
Jerónimo Sáiz-Ruiz ◽  
Marina Díaz-Marsá ◽  
Jesús César ◽  
Juan José López-Ibor
Keyword(s):  
Monoamine Oxidase ◽  
Sensation Seeking ◽  
Behavioral Pattern ◽  
Control Group ◽  
Platelet Mao ◽  
Isotopic Methods ◽  
Healthy Control ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Platelet Monoamine Oxidase

AbstractIn this study, we attempt to demonstrate an association between low platelet monoamine oxidase (MAO) activity, as assessed by isotopic methods, and the stable behavioral pattern of sensation- and risk-seeking of professional bull-fighters. Sixteen professional bullfighters were studied and compared with a control group of 46 healthy control subjects who did not engage in risky jobs or activities. The group of bullfighters had significantly reduced platelet MAO activity compared with the control group (P<0.05). Bullfighters were shown to be significantly more extroverted and sensation-seeking than controls on various temperament scales. A predisposition to engage in risky activities (eg, bullfighting) and sensation-seeking could be partly conditioned by the presence of biological components of personality manifested by a significantly decreased platelet MAO activity.

scholarly journals Studies on the active site of pig plasma amine oxidase

1989 ◽  
Vol 264 (3) ◽  
pp. 663-669 ◽  
Author(s):  
D Collison ◽  
P F Knowles ◽  
F E Mabbs ◽  
F X Rius ◽  
I Singh ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Active Site ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Spectral Characteristics ◽  
Pyrroloquinoline Quinone ◽  
Amine Oxidases ◽  
Assay Procedure ◽  
Plasma Amine Oxidase ◽  
Amine Oxidase Activity

Amine oxidase from pig plasma (PPAO) has two bound Cu2+ ions and at least one pyrroloquinoline quinone (PQQ) moiety as cofactors. It is shown that recovery of activity by copper-depleted PPAO is linear with respect to added Cu2+ ions. Recovery of e.s.r. and optical spectral characteristics of active-site copper parallel the recovery of catalytic activity. These results are consistent with both Cu2+ ions contributing to catalysis. Further e.s.r. studies indicate that the two copper sites in PPAO, unlike those in amine oxidases from other sources, are chemically distinct. These comparative studies establish that non-identity of the Cu2+ ions in PPAO is not a requirement for amine oxidase activity. It is shown through the use of a new assay procedure that there are two molecules of PQQ bound per molecule of protein in PPAO; only the more reactive of these PQQ moieties is required for activity.

Genetic analysis of plasma amine oxidase activity in schizophrenia

1985 ◽  
Vol 15 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Miron Baron ◽  
Neil Risch ◽  
Morton Levitt ◽  
Rhoda Gruen
Keyword(s):  
Genetic Analysis ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Plasma Amine Oxidase ◽  
Amine Oxidase Activity

scholarly journals Inhibition of beef plasma amine oxidase activity by glycine

FEBS Letters ◽  
1978 ◽  
Vol 94 (1) ◽  
pp. 112-114 ◽  
Author(s):  
M.T. Costa ◽  
S. Sabatini ◽  
P. Turini ◽  
B. Mondovì
Keyword(s):  
Oxidase Activity ◽  
Amine Oxidase ◽  
Plasma Amine Oxidase ◽  
Amine Oxidase Activity

Platelet and plasma amine oxidase activity in 680 normals: Sex and age differences and stability over time

1976 ◽  
Vol 16 (3) ◽  
pp. 254-265 ◽  
Author(s):  
D.L. Murphy ◽  
C. Wright ◽  
M. Buchsbaum ◽  
A. Nichols ◽  
J.L. Costa ◽  
...  
Keyword(s):  
Age Differences ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Plasma Amine Oxidase ◽  
Sex And Age Differences ◽  
Over Time ◽  
Amine Oxidase Activity

Monoamine Oxidase Activity: A Genetic Marker of Schizophrenia?

1974 ◽  
Vol 23 (S1) ◽  
pp. 371-376 ◽  
Author(s):  
F. Owen ◽  
A. Pauline Ridges ◽  
I. B. Cookson
Keyword(s):  
Monoamine Oxidase ◽  
Control Group ◽  
Pilot Studies ◽  
Methyl Transferase ◽  
Platelet Mao ◽  
Significant Difference ◽  
History Of ◽  
Mao Activity ◽  
Schizophrenic Group ◽  
Platelet Mao Activity

The results of pilot studies of the activities of platelet monoamine oxidase (MAO) and catechol-0-methyl transferase (COMT) in the blood of selected schizophrenics and the families of schizophrenics is presented.No statistically significant difference was found between the blood COMT levels of 21 control subjects and 26 schizophrenics, whereas the values found for platelet MAO activity were significantly lower for the schizophrenic group than for the control group.In one acutely disturbed first-admission schizophrenic the platelet MAO activity increased to a normal level in parallel with the clinical improvement, whereas in the relapsing schizophrenics the platelet MAO activity remained at its initial level although the clinical picture improved. No consistent findings with regard to the platelet MAO activity emerged from the study of 3 families having a history of schizophrenia.

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